Mohammad Saki
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View article: iSHELL Observations of Halley-Type Comet 13P/Olbers: Investigating Primary Volatile Composition in a Rare Dynamical Class.
iSHELL Observations of Halley-Type Comet 13P/Olbers: Investigating Primary Volatile Composition in a Rare Dynamical Class. Open
Halley-type comets (HTCs) occupy a unique niche in our understanding of the solar system’s formation and evolution. With orbital periods between those of Jupiter-family comets (JFCs) and long-period Oort cloud comets (OCCs), HTCs share a l…
View article: Enriched CO and CH4 abundances in Halley-Type Comet 13P/Olbers through high-resolution near-IR spectroscopy
Enriched CO and CH4 abundances in Halley-Type Comet 13P/Olbers through high-resolution near-IR spectroscopy Open
Comets contain the best-preserved known remnant material of solar system formation. Their volatile compositions provide clues to extant conditions in the protosolar disk at the time and place of their formation [[i],[ii]]. Subsequent gravi…
View article: Comet 12P/Pons-Brooks: The Importance of Halley-Type Comets to Understanding the Early Solar System
Comet 12P/Pons-Brooks: The Importance of Halley-Type Comets to Understanding the Early Solar System Open
Comets are remnants from the early solar system and retain volatiles from the time and place of their formation in the outer protoplanetary disk. Gravitational interactions with the young giant planets scattered many of them into one of tw…
View article: From Deep Impact to the Comet Interceptor: Integrating ground-based near-infrared spectroscopic measurements of volatiles with spacecraft cometary missions
From Deep Impact to the Comet Interceptor: Integrating ground-based near-infrared spectroscopic measurements of volatiles with spacecraft cometary missions Open
Comet research has been a high priority in solar system exploration. The last two decades have witnessed three spacecraft missions to short-period comets (Stardust / NExT, Deep Impact / EPOXI, and Rosetta) as well as tremendously increased…
View article: Brachial Plexopathy in Head and Neck Cancer Potentially Related to LET-Dependent RBE
Brachial Plexopathy in Head and Neck Cancer Potentially Related to LET-Dependent RBE Open
Proton beam therapy for head and neck cancers traditionally employs a fixed relative biological effectiveness (RBE) of 1.1, which may underestimate actual biological effects in critical structures. This study evaluates how Linear Energy Tr…
View article: Operational Improvement of a Proton Therapy System From Reduced Energy Layer Switching Time
Operational Improvement of a Proton Therapy System From Reduced Energy Layer Switching Time Open
View article: Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 au
Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 au Open
Comet C/2017 K2 (Pan-STARRS) provided a rare opportunity to investigate the evolution of coma composition and outgassing patterns over a transitional heliocentric distance ( R h ) range where activity drivers in comets are thought to chang…
View article: Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 AU
Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 AU Open
Comet C/2017 K2 (Pan-STARRS) provided a rare opportunity to investigate the evolution of coma composition and outgassing patterns over a transitional heliocentric distance (Rh) range where activity drivers in comets are thought to change f…
View article: Navigating Complexities: Leadless Pacemaker Management in Proton Therapy for a Pacemaker-Dependent Bilateral Breast Cancer Patient
Navigating Complexities: Leadless Pacemaker Management in Proton Therapy for a Pacemaker-Dependent Bilateral Breast Cancer Patient Open
View article: Parent Volatile Outgassing Associations in Cometary Nuclei: Synthesizing Rosetta Measurements and Ground-based Observations
Parent Volatile Outgassing Associations in Cometary Nuclei: Synthesizing Rosetta Measurements and Ground-based Observations Open
Comets, as remnants of the solar system’s formation, vary in volatile-refractory content. In situ comet studies, such as the Rosetta mission to 67P/Churyumov–Gerasimenko, provide detailed volatile composition insights, while ground-based s…
View article: Coma Abundances of Volatiles at Small Heliocentric Distances: Compositional Measurements of Long-period Comet C/2020 S3 (Erasmus)
Coma Abundances of Volatiles at Small Heliocentric Distances: Compositional Measurements of Long-period Comet C/2020 S3 (Erasmus) Open
We report production rates of H 2 O and nine trace molecules (C 2 H 6 , CH 4 , H 2 CO, CH 3 OH, HCN, NH 3 , C 2 H 2 , OCS, and CO) in long-period comet C/2020 S3 (Erasmus) using the high-resolution, cross-dispersed infrared spectrograph (i…
View article: The Return of the Rosetta Target: Keck Near-infrared Observations of Comet 67P/Churyumov–Gerasimenko in 2021
The Return of the Rosetta Target: Keck Near-infrared Observations of Comet 67P/Churyumov–Gerasimenko in 2021 Open
High-resolution near-infrared ground-based spectroscopic observations of comet 67P/Churyumov–Gerasimenko near its maximum activity in 2021 were conducted from the W. M. Keck Observatory, using the facility spectrograph NIRSPEC. 67P is the …
View article: Palomar discovery and initial characterization of naked-eye long-period comet C/2022 E3 (ZTF)
Palomar discovery and initial characterization of naked-eye long-period comet C/2022 E3 (ZTF) Open
Long-period comets are planetesimal remnants constraining the environment and volatiles of the protoplanetary disc. We report the discovery of hyperbolic long-period comet C/2022 E3 Zwicky Transient Facility (ZTF), which has a perihelion ∼…
View article: Palomar discovery and initial characterization of naked-eye long period comet C/2022 E3 (ZTF)
Palomar discovery and initial characterization of naked-eye long period comet C/2022 E3 (ZTF) Open
Long-period comets are planetesimal remnants constraining the environment and volatiles of the protoplanetary disc. We report the discovery of hyperbolic long-period comet C/2022 E3 (ZTF), which has a perihelion $\sim$1.11 au, an eccentric…
View article: Spectroscopic identification of water emission from a main-belt comet: Supporting data and code
Spectroscopic identification of water emission from a main-belt comet: Supporting data and code Open
Reduced data, source files, and code used in the analysis of JWST spectroscopy of comet 238P/Read, by Kelley et al. (2023, Nature 619, 720. 10.1038/s41586-023-06152-y).
View article: Spectroscopic identification of water emission from a main-belt comet
Spectroscopic identification of water emission from a main-belt comet Open
Main-belt comets are small Solar System bodies located in the asteroid belt that repeatedly exhibit comet-like activity (that is, dust comae or tails) during their perihelion passages, strongly indicating ice sublimation 1,2 . Although the…
View article: Spectroscopic identification of water emission from a main-belt comet: Supporting data and code
Spectroscopic identification of water emission from a main-belt comet: Supporting data and code Open
Reduced data, source files, and code used in the analysis of JWST spectroscopy of comet 238P/Read, by Kelley et al. (2023, Nature 619, 720. 10.1038/s41586-023-06152-y).
View article: Comprehensive Study of the Chemical Composition and Spatial Outgassing Behavior of Hyperactive Comet 46P/Wirtanen Using Near-IR Spectroscopy during its Historic 2018 Apparition
Comprehensive Study of the Chemical Composition and Spatial Outgassing Behavior of Hyperactive Comet 46P/Wirtanen Using Near-IR Spectroscopy during its Historic 2018 Apparition Open
We present a comprehensive analysis of the chemical composition of the Jupiter-family comet and potential spacecraft target 46P/Wirtanen, in the near-IR wavelength range. We used iSHELL at the NASA Infrared Telescope Facility to observe th…
View article: Figure S4 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S4 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
MT-EGFR expression in HBEC cells is associated with dramatically elevated levels of replication factors.
View article: Figure S1 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S1 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
MT-EGFR expression reduces survival in NSCLCs and HBEC cells.
View article: SF Legends from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
SF Legends from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
Supplementary Figure Legends.
View article: Data from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Data from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
EGFR signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non–small cell lung carcinomas (NSCLC) with activating L858R or ΔE746-E750 EGFR mutations exhibit elevated EGFR activity and downstream signa…
View article: Figure S5 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S5 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
Ectopic MT-EGFR expression significantly reduces hypoxia-associated radiation resistance in A549 NSCLC cells.
View article: Figure S2 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S2 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
MT-EGFR expression has marginal effects on endogenous reducing environment in NSCLCs or HBEC.
View article: Figure S2 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S2 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
MT-EGFR expression has marginal effects on endogenous reducing environment in NSCLCs or HBEC.
View article: Figure S5 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S5 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
Ectopic MT-EGFR expression significantly reduces hypoxia-associated radiation resistance in A549 NSCLC cells.
View article: Figure S3 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S3 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
Camptothecin and hydroxyurea have differing effects on RPA associated H2AX foci in WT-EGFR expressing S-phase cells.
View article: Figure S1 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S1 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
MT-EGFR expression reduces survival in NSCLCs and HBEC cells.
View article: Data from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Data from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
EGFR signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non–small cell lung carcinomas (NSCLC) with activating L858R or ΔE746-E750 EGFR mutations exhibit elevated EGFR activity and downstream signa…
View article: Figure S3 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Figure S3 from EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair Open
Camptothecin and hydroxyurea have differing effects on RPA associated H2AX foci in WT-EGFR expressing S-phase cells.