Mohammad Shahbazy
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View article: Mass spectrometry-based thermostability profiling of virus-derived MHC peptide complexes serves as an effective predictor of immunogenicity
Mass spectrometry-based thermostability profiling of virus-derived MHC peptide complexes serves as an effective predictor of immunogenicity Open
The major histocompatibility complex (MHC) encodes molecules that present peptides on the surface of cells to stimulate T-cell-mediated immune responses. The stability of peptide-MHC class I complexes (pMHCI) has been postulated to influen…
View article: Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines Open
View article: Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies
Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies Open
Advances in immunotherapy rely on targeting novel cell surface antigens, including therapeutically relevant peptide fragments presented by HLA molecules, collectively known as the actionable immunopeptidome. Although the immunopeptidome of…
View article: MHCpLogics: an interactive machine learning-based tool for unsupervised data visualization and cluster analysis of immunopeptidomes
MHCpLogics: an interactive machine learning-based tool for unsupervised data visualization and cluster analysis of immunopeptidomes Open
The major histocompatibility complex (MHC) encodes a range of immune response genes, including the human leukocyte antigens (HLAs) in humans. These molecules bind peptide antigens and present them on the cell surface for T cell recognition…
View article: SAPrIm, a semi-automated protocol for mid-throughput immunopeptidomics
SAPrIm, a semi-automated protocol for mid-throughput immunopeptidomics Open
Human leukocyte antigen (HLA) molecules play a crucial role in directing adaptive immune responses based on the nature of their peptide ligands, collectively coined the immunopeptidome. As such, the study of HLA molecules has been of major…
View article: Benchmarking Bioinformatics Pipelines in Data-Independent Acquisition Mass Spectrometry for Immunopeptidomics
Benchmarking Bioinformatics Pipelines in Data-Independent Acquisition Mass Spectrometry for Immunopeptidomics Open
Immunopeptidomes are the peptide repertoires bound by the molecules encoded by the major histocompatibility complex [human leukocyte antigen (HLA) in humans]. These HLA-peptide complexes are presented on the cell surface for immune T-cell …
View article: Immunolyser: A web-based computational pipeline for analysing and mining immunopeptidomic data
Immunolyser: A web-based computational pipeline for analysing and mining immunopeptidomic data Open