Manish A. Shah
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View article: Pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer: 5-year extended follow-up for the randomized phase III KEYNOTE-590 study
Pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer: 5-year extended follow-up for the randomized phase III KEYNOTE-590 study Open
Data from KEYNOTE-590 continue to show durable efficacy after 5 years, and pembrolizumab plus chemotherapy more than tripled the 5-year overall survival rate compared with placebo plus chemotherapy, with no new safety signals. These result…
View article: Clinical and patient reported outcomes of inflatable penile prosthesis insertion in men under 35 years old
Clinical and patient reported outcomes of inflatable penile prosthesis insertion in men under 35 years old Open
View article: MON-039 A Race Against Time: The Rapid Course of Thymic Neuroendocrine Carcinoma
MON-039 A Race Against Time: The Rapid Course of Thymic Neuroendocrine Carcinoma Open
Disclosure: R. Devbhandari: None. M. Shah: None. S. Tripathee: None. H. Akbari: None. A. Kang: None. R.M. Jhingan: None. Introduction: Neuroendocrine tumors of the thymus (NETTs) are very rare, with fewer than 1,000 reported cases. Over 80…
View article: <b>BACILLUS CLAUSII: A PROBIOTIC APPROACH TO COMBATING INTESTINAL INFECTIONS</b>
<b>BACILLUS CLAUSII: A PROBIOTIC APPROACH TO COMBATING INTESTINAL INFECTIONS</b> Open
One of the most frequent causes of doctor visits worldwide is gastroenteritis. Acute gastrointestinal disorders are a major medical and financial concern. Such conditions need to be managed more skillfully. There is still much to learn abo…
View article: Smallholder farmers’ knowledge, attitudes and practices towards parthenium and biological control in Pakistan: A gendered perspective
Smallholder farmers’ knowledge, attitudes and practices towards parthenium and biological control in Pakistan: A gendered perspective Open
Background. Smallholder farmers have a significant role in contributing to improving the establishment and effectiveness of biological control agents through their on-farm management practices. Biological control offers a long-term sustain…
View article: KEY STAKEHOLDERS’ PERCEPTIONS REGARDING ADVANCED PRACTICE NURSING IN PAKISTAN
KEY STAKEHOLDERS’ PERCEPTIONS REGARDING ADVANCED PRACTICE NURSING IN PAKISTAN Open
Aim: To explore the perceptions of key stakeholders regarding advanced practice nursing in Pakistan. Methodology: A qualitative case study research design was employed to facilitate an in-depth exploration of perceptions within a defined c…
View article: 71841 | Outcomes of Same-day vs. Delayed Discharge After LAAC Using a Fluoropolymer Coated Device: HEAL-LAA Post Approval Study Sub-analysis
71841 | Outcomes of Same-day vs. Delayed Discharge After LAAC Using a Fluoropolymer Coated Device: HEAL-LAA Post Approval Study Sub-analysis Open
View article: 724 Impact of Positive Resection Margin After Gastrectomy on Recurrence and Overall Survival in Patients with Gastric Carcinoma
724 Impact of Positive Resection Margin After Gastrectomy on Recurrence and Overall Survival in Patients with Gastric Carcinoma Open
Aim The purpose of this study is to determine the recurrence rate, overall survival (OS), and disease-free (DFS) of patients with a positive resection margin compared with patients with a negative margin. Method Retrospective Cohort Study.…
View article: PREVALENCE AND REASONS FOR EARLIER THAN DESIRED CESSATION OF EXCLUSIVE BREASTFEEDING (6 MONTHS) AFTER BIRTH IN MOTHERS OF THE CHILDREN ADMITTED IN OBS/PAEDS WARDS OF A PRIVATE SECTOR HOSPITAL, PESHAWAR
PREVALENCE AND REASONS FOR EARLIER THAN DESIRED CESSATION OF EXCLUSIVE BREASTFEEDING (6 MONTHS) AFTER BIRTH IN MOTHERS OF THE CHILDREN ADMITTED IN OBS/PAEDS WARDS OF A PRIVATE SECTOR HOSPITAL, PESHAWAR Open
Background: Breastfeeding is recognized globally as the most natural and beneficial way to ensure healthy growth and development in infants. Human breast milk provides all essential nutrients, antibodies, and hormones necessary for optimal…
View article: Evolving Therapeutics for Resectable Esophageal Adenocarcinoma
Evolving Therapeutics for Resectable Esophageal Adenocarcinoma Open
Surgical resection remains the backbone of curative treatment for localized esophageal adenocarcinoma. However, resection alone carries a significant risk of recurrence and is no longer considered an acceptable approach for patients with l…
View article: Comparison of left atrial appendage closure and oral anti-coagulation after catheter ablation for atrial fibrillation: Concomitant and sequential cohorts of the OPTION randomized controlled trial
Comparison of left atrial appendage closure and oral anti-coagulation after catheter ablation for atrial fibrillation: Concomitant and sequential cohorts of the OPTION randomized controlled trial Open
For both Concomitant and Sequential ablation timing strategies, LAAC has similar efficacy compared with OAC and a lower risk of clinically important post-procedure bleeding in high-risk patients following AF ablation.
View article: Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities
Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities Open
We developed a tumor-matched, pan-cancer patient-derived organoid (PDO) platform comprising 220 PDOs from 190 patients across 15 cancer types to advance functional precision oncology. Our comprehensively characterized PDOs showed 93% histo…
View article: A comparison of Islamic religious practices in Pakistan and Indonesia: A sociocultural perspective
A comparison of Islamic religious practices in Pakistan and Indonesia: A sociocultural perspective Open
Islam is the majority religion in both Pakistan and Indonesia, the two countries with the largest Muslim populations in the world. While both uphold Islam as the primary faith, religious practices in each country are influenced by differin…
View article: Whole Genome Analysis Identifies Homologous Recombination Deficiency in Cancers with BRCA1/2 Wild-Type and BRCA1/2 Structural Variants
Whole Genome Analysis Identifies Homologous Recombination Deficiency in Cancers with BRCA1/2 Wild-Type and BRCA1/2 Structural Variants Open
Purpose Homologous recombination deficiency (HRD) impacts cancer treatment strategies, particularly effective utilization of PARP inhibitors. However, the variability of different HRD assays has hampered the selection of oncology patients …
View article: ANTIBIOGRAM ASSAY OF E.COLI ISOLATES IN PATIENTS WITH URINARY TRACT INFECTION
ANTIBIOGRAM ASSAY OF E.COLI ISOLATES IN PATIENTS WITH URINARY TRACT INFECTION Open
Screening of prevalent bacterial pathogens for antibiotic susceptibility profiles in different regions is necessary. E. coli and other pathogens are so common in our environment that it is essential to monitor trends in antibiotic suscepti…
View article: Supplementary Data 1 from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Supplementary Data 1 from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma Open
Supplementary Data
View article: Supplementary Data 1 from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Supplementary Data 1 from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma Open
Supplementary Data
View article: Data from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Data from ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma Open
Background: Zolbetuximab, an IgG1 monoclonal antibody, binds to claudin 18.2 (CLDN18.2) and mediates tumor cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. We sought to examine zolbetuximab…
View article: Zolbetuximab in Gastric or Gastroesophageal Junction Adenocarcinoma
Zolbetuximab in Gastric or Gastroesophageal Junction Adenocarcinoma Open
View article: Preoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction
Preoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction Open
Importance The prognosis of patients with adenocarcinoma of the esophagus and esophagogastric junction (AEG) is poor. From current evidence, it remains unclear to what extent preoperative chemoradiotherapy (CRT) or preoperative and/or peri…
View article: Integrative Transcriptomic and Single-Cell Protein Characterization of Colorectal Carcinoma Delineates Distinct Tumor Immune Microenvironments Associated with Overall Survival
Integrative Transcriptomic and Single-Cell Protein Characterization of Colorectal Carcinoma Delineates Distinct Tumor Immune Microenvironments Associated with Overall Survival Open
Colorectal carcinoma (CRC) is a heterogeneous group of tumors with varying therapeutic response and prognosis, and evidence suggests the tumor immune microenvironment (TIME) plays a pivotal role. Using advanced molecular and spatial biolog…
View article: Global prevalence of claudin 18 isoform 2 in tumors of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma
Global prevalence of claudin 18 isoform 2 in tumors of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma Open
View article: Health-related quality-of-life analysis from KEYNOTE-590: pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer
Health-related quality-of-life analysis from KEYNOTE-590: pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer Open
Background In the KEYNOTE-590 study, first-line pembrolizumab plus chemotherapy provided statistically significant improvement in overall survival, progression-free survival, and objective response rate compared with chemotherapy, with a m…
View article: Zolbetuximab plus chemotherapy for locally advanced unresectable or metastatic stomach or gastroesophageal junction cancers: a plain language summary
Zolbetuximab plus chemotherapy for locally advanced unresectable or metastatic stomach or gastroesophageal junction cancers: a plain language summary Open
In SPOTLIGHT and GLOW, on average, participants assigned to zolbetuximab plus chemotherapy lived 1.4 to 1.9 months longer before their tumors grew bigger or new tumors grew, after starting the trial, than participants assigned to a plac…
View article: LEAP-014: first-line lenvatinib + pembrolizumab + chemotherapy in advanced/metastatic esophageal squamous cell carcinoma
LEAP-014: first-line lenvatinib + pembrolizumab + chemotherapy in advanced/metastatic esophageal squamous cell carcinoma Open
Treatment options for patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) are improving. Current guidelines recommend first-line pembrolizumab plus chemotherapy for patients with unresectable or metastatic ESCC, …
View article: Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint Blockade
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint Blockade Open
Although gastric cancer (GC) may be classified into molecular subtypes based on the TCGA1 or ACRG2 classification, the tumor immune microenvironment (TME) remains under-evaluated in both systems. Using unsupervised cl…
View article: FACTORS ASSOCIATED WITH OUTCOMES IN LAPAROSCOPIC COLONIC SURGERY: A ANALYSIS OF EARLY EXPERIENCE
FACTORS ASSOCIATED WITH OUTCOMES IN LAPAROSCOPIC COLONIC SURGERY: A ANALYSIS OF EARLY EXPERIENCE Open
Laparoscopic-assisted colonic (LAC) surgery has gained acceptance for various colonic diseases, yet comprehensive studies on diverse patient demographics and procedural outcomes are essential. This study aimed to evaluate 96 LAC surgeries,…
View article: COMPARISON OF LAPAROSCOPIC AND OPEN APPENDECTOMY IN TERMS OF SURGICAL SITE INFECTION
COMPARISON OF LAPAROSCOPIC AND OPEN APPENDECTOMY IN TERMS OF SURGICAL SITE INFECTION Open
Appendectomy is a common surgical procedure, and the choice between laparoscopic and open approaches has clinical significance. Surgical site infection (SSI) is a critical postoperative complication. This study aimed to compare laparoscopi…
View article: Safety profile of pembrolizumab monotherapy based on an aggregate safety evaluation of 8937 patients
Safety profile of pembrolizumab monotherapy based on an aggregate safety evaluation of 8937 patients Open
View article: 586 Phase II study of Telomelysin (OBP-301) in combination with pembrolizumab in gastroesophageal (GEA) adenocarcinoma
586 Phase II study of Telomelysin (OBP-301) in combination with pembrolizumab in gastroesophageal (GEA) adenocarcinoma Open
Background OBP-301 is a novel, oncolytic adenovirus that incorporates the human telomerase reverse transcriptase promoter for replication selectivity. As a single agent, OBP-301 demonstrated immune responses and clinical activity in phase …