Explanipedia

Publisher Correction: Academia Europaea’s guidelines for the visualization of clinical outcomes Open

Péter Hegyi, András Garami, Àlvar Agustí, Charles Agyemang, Arturo Anadón , et al. · 2025

SAT-656 Sex-Dependent Regulation of Body Composition by Adipocyte FSHR Open

Guzel Burganova, Anisa Gumerova, Georgii Pevnev, Zahra Nakadar, Peter Shyu , et al. · 2025

Disclosure: G. Burganova: None. A. Gumerova: None. G. Pevnev: None. Z. Nakadar: None. P.T. Shyu: None. G.F. Guerriero: None. U. Cheliadinova: None. S.L. Sims: None. O. Moldavski: None. O. Barak: None. X.E. Guo: None. D. Lizneva: None. T. Y…

OR35-04 Genetic Circuitry of LHCGR: a Modulator of Body Composition and Metabolic Traits in Humans Open

Hasni Kannangara, Ofer Moldavski, Anisa Gumerova, Uliana Cheliadinova, Georgii Pevnev , et al. · 2025

Disclosure: H. Kannangara: None. O. Moldavski: None. A. Gumerova: None. U. Cheliadinova: None. G. Pevnev: None. P. Surabhi: None. D. Vasilyeva: None. L. Igel: None. O. Barak: None. S. Haider: None. T. Yuen: None. M. Zaidi: None. D. Lizneva…

SUN-219 Distribution and characterization of single transcript level of brain erythroferrone in 3xTg mouse model of Alzheimer's disease Open

Vitaly Ryu, Ronit Witztum, Anisa Gumerova, Steven Lee Sims, Ofer Moldavski , et al. · 2025

Disclosure: V. Ryu: None. R. Witztum: None. A. Gumerova: None. S.L. Sims: None. O. Moldavski: None. F. Korkmaz: None. M. Planoutene: None. M. Levy: None. P. Na-Phatthalung: None. G. Pevnev: None. J. Ryu: None. B. Tumoglu: None. O. Barak: N…

MON-018 Sex Differences In Oxytocin And Oxytocin Receptor Expression In The Mouse Brain: Comprehensive Single Transcript Level Mapping Open

Georgii Pevnev, Anisa Gumerova, Funda Korkmaz, Hasni Kannangara, Liam Cullen , et al. · 2025

Disclosure: G. Pevnev: None. A. Gumerova: None. F. Korkmaz: None. H.S. Kannangara: None. L. Cullen: None. R. Witztum: None. S.L. Sims: None. T. Frolinger: None. O. Moldavski: None. O. Barak: None. G. Burganova: None. D. Lizneva: None. K. G…

SUN-040 A α-synuclein Mouse Model Of Parkinson Disease For Studying Fsh Effects Open

Steven Lee Sims, Frolinger Tal, A. Gangadhar, Anisa Gumerova, Zehra Berna Tumoglu , et al. · 2025

Disclosure: S.L. Sims: None. F. Tal: None. A. Gangadhar: None. A.A. Gumerova: None. Z.B. Tumoglu: None. J. Gimenez Roig: None. A.R. Pallapati: None. F. Sultana: None. S. Parte: None. V. Ryu: None. T. Yuen: None. M. Zaidi: None. R. Latif: N…

The FSIP Family: Roles in Health and Cancer Open

Zhan Zhang, Y. Liu, Chao Liu, Lina Qin, Mone Zaidi , et al. · 2025

Fibrous sheath interacting proteins 1 and 2 (FSIP1 and FSIP2) are evolutionarily conserved testis-specific antigens, exclusively expressed in germ cells of adult human tissues, where they play essential roles in spermatogenesis and testicu…

Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer’s disease models Open

Anusha Pallapati, Funda Korkmaz, Satish Rojekar, Steven Sims, Anurag Misra , et al. · 2025

There is growing evidence for direct actions of follicle-stimulating hormone (FSH) on tissues other than the ovaries and testes. Blocking FSH action, either genetically or pharmacologically, protects against bone loss, fat gain, and memory…

Extending the Graves’ Triad: Thyroid Eye Disease, Dermopathy, and Acropachy: A Clinical Response to Teprotumumab Open

Javier Lira, P.M. Dixon, Mone Zaidi, Se‐Min Kim · 2025

Thyroid acropachy is a rare extrathyroidal manifestation of Graves’ disease. Due to a limited understanding of the pathophysiology, no specific treatment exists. Here we discuss such a case and its response to treatment. A 25-year-old male…

Abstract 2134 Further Studies on Effects of FSH–Blocking Antibody in Preventing Osteoporosis, Obesity and Alzheimer's Disease Open

Anusha Pallapati, Funda Korkmaz, Satish Rojekar, Steven Sims, Anurag Misra , et al. · 2025

Gender–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain Open

Anisa Gumerova, Georgii Pevnev, Funda Korkmaz, Uliana Cheliadinova, Guzel Burganova , et al. · 2025

Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary via the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure …

Gender–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain Open

Anisa Gumerova, Georgii Pevnev, Funda Korkmaz, Uliana Cheliadinova, Guzel Burganova , et al. · 2025

Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary via the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure …

Introduction from the New Editor of Diversity, Justice and Action Open

Mone Zaidi · 2025

Gender–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain Open

Anisa Gumerova, Georgii Pevnev, Funda Korkmaz, Uliana Cheliadinova, Guzel Burganova , et al. · 2024

Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary via the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure …

Gene–dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer’s mice Open

Funda Korkmaz, Steven Sims, Fazilet Şen, Farhath Sultana, Victoria Laurencin , et al. · 2024

TSH enhances neurite outgrowth Open

Mohd Nizam Mansoori, Rauf Latif, Syed A. Morshed, Mone Zaidi, Terry F. Davies · 2024

Extra-thyroidal effects of TSH have been reported in various tissues expressing the TSH receptor (TSHR) including several areas of the brain. However, the influence of TSH on neuronal phenotypes has not been examined. Using a well-characte…

8734 Absent FSH Signaling Rescues Spatial and Recognition Memory Impairments in Female 3xTg Mice Open

Steven Sims, Fazilet Şen, Farhath Sultana, Avi Liu, Victoria Laurencin , et al. · 2024

Disclosure: S. Sims: None. F. Sen: None. F. Sultana: None. A. Liu: None. V. Laurencin: None. A. Gumerova: None. O. Barak: None. S. Rojekar: None. A.R. Pallapati: None. L. Cullen: None. R. Chen: None. K. Goosens: None. V. Ryu: None. T. Yuen…

8693 Dexamethasone Increases Bone Mass In Mice Open

Farhath Sultana, Morgan L Temple, Se Min Kim, Vitaly Ryu, Funda Korkmaz , et al. · 2024

Disclosure: F. Sultana: None. M.L. Temple: None. S. Kim: None. V. Ryu: None. F. Korkmaz: None. A. Gumerova: None. P. Georgii: None. U. Cheliadinova: None. D. Vasilyeva: None. V. Laurencin: None. R. Witztum: None. O. Barak: None. L. Cullen:…

7865 Thyroid Acropachy: A Clinical Response to Teprotumumab Open

Javier Lira, Mone Zaidi, Seon Mee Kim · 2024

Disclosure: J. Lira: None. M. Zaidi: None. S. Kim: None. Background: Thyroid acropachy is a rare extrathyroidal manifestation of Graves disease (1). Due to its rarity, generally benign clinical course and the limited understanding of its p…

8631 Tanycytic TSHR Activation Regulates Blood-Hypothalamus Barrier Plasticity, Ingestive Behavior, Adipose Remodeling, and Body Weight Open

Liam Cullen, Hasni Kannangara, Ronit Witztum, JoColl Burgess, Sari Miyashita , et al. · 2024

Disclosure: L. Cullen: None. H.S. Kannangara: None. R. Witztum: None. J. Burgess: None. S. Miyashita: None. A. Gumerova: None. F. Korkmaz: None. S.L. Sims: None. U. Cheliadinova: None. G. Pevnev: None. O. Moldavski: None. O. Barak: None. S…

An atlas of brain-bone sympathetic neural circuits in mice Open

Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Liam Cullen , et al. · 2024

There is clear evidence that the sympathetic nervous system (SNS) mediates bone metabolism. Histological studies show abundant SNS innervation of the periosteum and bone marrow–these nerves consist of noradrenergic fibers that immunostain …

Author response: An atlas of brain-bone sympathetic neural circuits in mice Open

Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Liam Cullen , et al. · 2024

Understanding osteokine biology Open

Mone Zaidi, Samir Zaidi, Tony Yuen · 2024

Gene–Dose–Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer’s Mice Open

Tal Frolinger, Funda Korkmaz, Steven Sims, Fazilet Şen, Farhath Sultana , et al. · 2024

Alzheimer’s disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post–menopausal levels of the pituitary gonadotropin follicle–stimulating hormone (FSH) are strongly associated with the onset of AD, …

Gene–Dose–Dependent Reduction<i>Fshr</i>Expression Improves Spatial Memory Deficits in Alzheimer’s Mice Open

Funda Korkmaz, Steven Sims, Fazilet Şen, Farhath Sultana, Victoria Laurencin , et al. · 2024

Alzheimer’s disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post–menopausal levels of the pituitary gonadotropin follicle–stimulating hormone (FSH) are strongly associated with the onset of AD, …

Higher FSH Level Is Associated With Increased Risk Of Incident Hip Fracture In Older Adults, Independent Of Sex Hormone Levels Open

Eileen H Koh, Susan K. Ewing, Sigurður Sigurðsson, Vilmundur Guðnason, Trisha F. Hue , et al. · 2024

Context Higher levels of follicle stimulating hormone (FSH) are associated with bone loss among women during the perimenopausal transition and among older men, independent of estradiol and testosterone levels, but it is unknown whether hig…

Single Transcript Level Atlas of Oxytocin and the Oxytocin Receptor in the Mouse Brain Open

Vitaly Ryu, Anisa Gumerova, Georgii Pevnev, Funda Korkmaz, Hasni Kannangara , et al. · 2024

Oxytocin (OXT), a primitive nonapeptide known to regulate reproduction and social behaviors, is synthesized primarily in the hypothalamus and is secreted via hypophyseal-portal system of the posterior pituitary gland. Given that pituitary …

An Atlas of Brain–Bone Sympathetic Neural Circuits Open

Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Hasni Kannangara , et al. · 2024

There is clear evidence that the sympathetic nervous system (SNS) mediates bone metabolism. Histological studies show abundant SNS innervation of the periosteum and bone marrow––these nerves consist of noradrenergic fibers that immunostain…

Musculoskeletal and neurocognitive clinical significance of adult hypophosphatasia Open

Se‐Min Kim, Funda Korkmaz, Steven Sims, Vitaly Ryu, Tony Yuen , et al. · 2023

Hypophosphatasia (HPP), also called Rathbun disease, is a rare genetic disorder that is caused by the loss-of-function mutation in the ALPL gene encoding tissue non-specific alkaline phosphatase. Doctor Rathbun first described the c…

eLife assessment: Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells Open

Mone Zaidi · 2023

Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Mycobacterium tubercul…

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