Mohammad Yaser Anwar
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View article: Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease
Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease Open
While the earliest pathological signs of cardiovascular disease (CVD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of high-risk children. With the rising prevalence of childhood obesity,…
View article: A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals
A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals Open
View article: Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci Open
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals
A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals Open
Background Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions having both genetic and environmental contributions, disproportionately affecting African American (AA) individuals. Recent evidence is contradictory reg…
View article: The Circulating Lipidome In Severe Obesity
The Circulating Lipidome In Severe Obesity Open
Background Severe obesity (SevO; BMI ≥40 kg/m²) is rapidly increasing globally and disproportionately affects minority populations. However, it remains understudied in mechanistic and omics literature. Lipid metabolism plays a central role…
View article: WEDANG KACANG MERAH MENINGKATKAN HEMOGLOBIN, HEMATOKRIT, DAN ERITROSIT IBU HAMIL DENGAN KASUS ANEMIA
WEDANG KACANG MERAH MENINGKATKAN HEMOGLOBIN, HEMATOKRIT, DAN ERITROSIT IBU HAMIL DENGAN KASUS ANEMIA Open
Effective nutritional management is needed because anemia during pregnancy has a major impact on the mother and fetus. Iron, folic acid, and vitamin B are abundant in red beans and play a role in erythrocytes, hemoglobin, and hematocrit pr…
View article: COMPARATIVE STUDY ON THE INCIDENCE, RISK FACTORS AND CLINICAL ASPECTS OF HIV/AIDS IN PATIENTS OF QUETTA DISTRICT, BALOCHISTAN.
COMPARATIVE STUDY ON THE INCIDENCE, RISK FACTORS AND CLINICAL ASPECTS OF HIV/AIDS IN PATIENTS OF QUETTA DISTRICT, BALOCHISTAN. Open
Background: HIV/AIDS remains a significant global health challenge, with over 38 million individuals affected as of 2022. Despite advancements in antiretroviral therapy (ART), the epidemic persists, particularly in regions with socioeconom…
View article: Molecular architecture of human atherosclerosis revealed through integrative human genetics
Molecular architecture of human atherosclerosis revealed through integrative human genetics Open
Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…
View article: Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM Open
Polygenic severe obesity (body mass index [BMI] ≥40 kg/m2) has increased, especially in Hispanic/Latino populations, yet we know little about the underlying mechanistic pathways. We analyzed whole-blood multiomics data to identi…
View article: Intersecting Pandemics: Analyzing the Relationship between Mpox and COVID-19Authors and Departments:
Intersecting Pandemics: Analyzing the Relationship between Mpox and COVID-19Authors and Departments: Open
The re-emergence of the mpox (formerly known as monkey pox) virus following the COVID-19 pandemic poses significant challenges to global public health. This review examines the epidemiological trends of mpox, highlighting a marked increase…
View article: Machine learning‐based clustering identifies obesity subgroups with differential multi‐omics profiles and metabolic patterns
Machine learning‐based clustering identifies obesity subgroups with differential multi‐omics profiles and metabolic patterns Open
Objective Individuals living with obesity are differentially susceptible to cardiometabolic diseases. We hypothesized that an integrative multi‐omics approach might improve identification of subgroups of individuals with obesity who have d…
View article: Genetic architecture of routinely acquired blood tests in a British South Asian cohort
Genetic architecture of routinely acquired blood tests in a British South Asian cohort Open
Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Health…
View article: Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci
Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci Open
Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could provide more co…
View article: Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts
Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts Open
View article: Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC)
Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC) Open
View article: Assessing efficiency of fine-mapping obesity associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB Cohorts
Assessing efficiency of fine-mapping obesity associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB Cohorts Open
Inadequate representation of non-European ancestry populations in genome-wide association studies (GWAS) has limited opportunities to isolate functional variants. Fine-mapping in multi-ancestry populations should improve the efficiency of …
View article: Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations
Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations Open
Background Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and …
View article: Genetic Pleiotropy Underpinning Adiposity and Inflammation in Self-Identified Hispanic/Latino Populations
Genetic Pleiotropy Underpinning Adiposity and Inflammation in Self-Identified Hispanic/Latino Populations Open
Background Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and …
View article: Additional file 5 of Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations
Additional file 5 of Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations Open
Additional file 5. Supplementary Tables.
View article: Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study
Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study Open
Background African ancestry individuals with comparable overall anthropometric measures to Europeans have lower abdominal adiposity. To explore the genetic underpinning of different adiposity patterns, we investigated whether genetic risk …
View article: The association between alcohol intake and fecundability during menstrual cycle phases
The association between alcohol intake and fecundability during menstrual cycle phases Open
STUDY QUESTION Is increased alcohol intake in different phases of the menstrual cycle associated with fecundability in women? SUMMARY ANSWER Heavy intake (>6 drinks/week) of alcoholic beverages in the luteal phase and ovulatory subphase…
View article: Genetic Underpinnings of Regional Adiposity Distribution in African Americans: Assessments from the Jackson Heart Study
Genetic Underpinnings of Regional Adiposity Distribution in African Americans: Assessments from the Jackson Heart Study Open
Background African ancestry individuals with comparable overall anthropometric measures to Europeans have lower abdominal adiposity. To explore genetic underpinning of different adiposity patterns, we investigated if genetic risk scores fo…
View article: Diarrhea Patterns and Climate: A Spatiotemporal Bayesian Hierarchical Analysis of Diarrheal Disease in Afghanistan
Diarrhea Patterns and Climate: A Spatiotemporal Bayesian Hierarchical Analysis of Diarrheal Disease in Afghanistan Open
Subject to a high burden of diarrheal diseases, Afghanistan is also susceptible to climate change. This study investigated the spatiotemporal distribution of diarrheal disease in the country and how associated it is with climate variables.…
View article: Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence
Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence Open
Results indicate ARIMA models can be applied to forecast malaria patterns in Afghanistan, complementing current surveillance systems. The models provide a means to better understand malaria dynamics in a resource-limited context with minim…
View article: Trends in infectious disease incidence among children in Afghanistan at a time of public health services expansion
Trends in infectious disease incidence among children in Afghanistan at a time of public health services expansion Open
This study reviewed trends in the incidence of common communicable diseases among children under five years in Afghanistan between 2005 and 2013, a period of expansion of public health services. New visits to outpatient clinics constituted…
View article: MOESM5 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence
MOESM5 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence Open
Additional file 2. Area-Averaged of CMG 0.05 Deg Monthly EVI monthly 0.05 ().
View article: MOESM1 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence
MOESM1 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence Open
Additional file 1. Malaria Metadata.
View article: MOESM4 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence
MOESM4 of Time series analysis of malaria in Afghanistan: using ARIMA models to predict future trends in incidence Open
Additional file 3. Area-Averaged of Air temperature at surface (Daytime/Ascending) ().