Mohd Akhtar
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View article: CORRELATION OF CLINICAL LABORATORY PARAMETERS AND DEMOGRAPHY WITH PHARMACOKINETICS OF TACROLIMUS – A NARROW THERAPEUTIC INDEX DRUG
CORRELATION OF CLINICAL LABORATORY PARAMETERS AND DEMOGRAPHY WITH PHARMACOKINETICS OF TACROLIMUS – A NARROW THERAPEUTIC INDEX DRUG Open
Objectives: During clinical pharmacokinetic (PK) studies, human volunteers are subjected to screening with respect to clinical pathology parameters, based on which volunteers are considered healthy or not healthy. Even for the screened hea…
View article: Nanoemulsion of myricetin enhances its anti-tumor activity in nude mice of triple-negative breast cancer xenografts
Nanoemulsion of myricetin enhances its anti-tumor activity in nude mice of triple-negative breast cancer xenografts Open
Purpose Myricetin, a naturally occurring flavonoid exhibits good anti-cancer properties. However, its practical application is limited due to poor aqueous solubility and low bioavailability. To overcome these challenges, a nanoemulsion-bas…
View article: 921 A Rare Occurrence of Three Primary Malignancies of the Rectum, Kidney and Pancreas in a Same Patient: A Case Report
921 A Rare Occurrence of Three Primary Malignancies of the Rectum, Kidney and Pancreas in a Same Patient: A Case Report Open
Introduction Multiple Primary Malignancies (MPMs) are characterized by the presence of at least two distinct primary malignancies in a patient. The occurrence rate of MPMs is between 1.63% and 10.9% across articles. To our knowledge, this …
View article: FREQUENCY AND CLINICAL SPECTRA OF DIABETIC NEPHROPATHY IN TYPE I DIABETES MELLITUS IN CHILDREN HOSPITAL, LAHORE PAKISTAN
FREQUENCY AND CLINICAL SPECTRA OF DIABETIC NEPHROPATHY IN TYPE I DIABETES MELLITUS IN CHILDREN HOSPITAL, LAHORE PAKISTAN Open
Background: Diabetes is a metabolic condition in which the body is unable to generate an adequate amount of the hormone insulin Objectives: This study investigates the frequency and clinical spectrum of diabetic nephropathy in children wit…
View article: Development and Optimization of Piracetam and Shatavarin IV-Loaded Nanoemulsion for Alzheimer’s Disease Therapy: In Silico and Experimental Analysis
Development and Optimization of Piracetam and Shatavarin IV-Loaded Nanoemulsion for Alzheimer’s Disease Therapy: In Silico and Experimental Analysis Open
Alzheimer's disease (AD) presents a significant challenge due to cognitive decline resulting from nerve cell degeneration. Shatavarin IV, a prominent bioactive compound fromAsparagus racemosus and Piracetam, has been investigated fo…
View article: Ann-Based Computational Analysis with Hall Current in Gravitydriven Materials with Energy Transport Performance
Ann-Based Computational Analysis with Hall Current in Gravitydriven Materials with Energy Transport Performance Open
View article: Development and Evaluation of a Dapagliflozin-Loaded Bilosomal Nanocarrier for Enhanced Cardioprotection in Isoproterenol-Induced Heart Failure in Rats
Development and Evaluation of a Dapagliflozin-Loaded Bilosomal Nanocarrier for Enhanced Cardioprotection in Isoproterenol-Induced Heart Failure in Rats Open
View article: Navigating the therapeutic landscape of SGLT2 inhibitors in diabetes management: exploring efficacy and emerging concerns
Navigating the therapeutic landscape of SGLT2 inhibitors in diabetes management: exploring efficacy and emerging concerns Open
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are integral to diabetes treatment, facilitating renal glucose excretion and offering benefits in cardiovascular risk reduction, kidney function preservation, and weight management. However…
View article: Evaluation of Nephroprotective Activity of Maghz-e-Pambadāna (Kernel of Gossypium herbaceum L.) in Gentamicin-induced Nephrotoxicity
Evaluation of Nephroprotective Activity of Maghz-e-Pambadāna (Kernel of Gossypium herbaceum L.) in Gentamicin-induced Nephrotoxicity Open
Background: Gentamicin (GM) a widely used aminoglycoside antibiotic, was discovered in 1963 and from 1970s it is used parenterally. It is used to treat Gram-negative infections. The subsequent systemic use causes nephrotoxicity. GM alters …
View article: "Exploring Therapeutic Potential: Asparagus racemosus in Neurodegenerative Disorders and Enhanced Delivery through Nanoformulations
"Exploring Therapeutic Potential: Asparagus racemosus in Neurodegenerative Disorders and Enhanced Delivery through Nanoformulations Open
View article: EFFECT OF SULFORAPHANE (SF) IN BEHAVIOURAL ASSESSMENT IN INTRACEREBROVENTRICULAR AΒ (1-42) INDUCED WISTAR RAT MODEL: MORRIS WATER MAZE EXPERIMENT
EFFECT OF SULFORAPHANE (SF) IN BEHAVIOURAL ASSESSMENT IN INTRACEREBROVENTRICULAR AΒ (1-42) INDUCED WISTAR RAT MODEL: MORRIS WATER MAZE EXPERIMENT Open
View article: Curcumin Nanoemulsion: Unveiling Cardioprotective Effects via ACE Inhibition and Antioxidant Properties in Hypertensive Rats
Curcumin Nanoemulsion: Unveiling Cardioprotective Effects via ACE Inhibition and Antioxidant Properties in Hypertensive Rats Open
Background and Objectives: Curcumin, derived from Curcuma longa, is a well-known traditional medicinal compound recognized for its therapeutic attributes. Nevertheless, its efficacy is hampered by limited bioavailability, prompting researc…
View article: Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway Open
View article: Responses for the concerns raised for “alendronate reduces the cognitive and neurological disturbances induced by combined doses of d‐galactose and aluminum chloride in mice” (https://doi.org/10.1002/jat.4160) in Journal of Applied Toxicology
Responses for the concerns raised for “alendronate reduces the cognitive and neurological disturbances induced by combined doses of d‐galactose and aluminum chloride in mice” (https://doi.org/10.1002/jat.4160) in Journal of Applied Toxicology Open
We regret for the inadvertent errors in the manuscript that need to be corrected. The appropriate corrections and calculations are made as per the suggestions of the readers and journal team, which is not affecting the overall goal, discus…
View article: Neuroprotective role of DPP-4 inhibitor Linagliptin against neurodegeneration, neuronal insulin resistance and neuroinflammation induced by intracerebroventricular streptozotocin in rat model of Alzheimer’s disease
Neuroprotective role of DPP-4 inhibitor Linagliptin against neurodegeneration, neuronal insulin resistance and neuroinflammation induced by intracerebroventricular streptozotocin in rat model of Alzheimer’s disease Open
Alzheimer’s disease (AD) is an age-related, multifactorial progressive neurodegenerative disorder manifested by cognitive impairment and neuronal death in the brain hippocampus, yet the precise neuropathology of AD is still unclear. Contin…
View article: SALINITY TOLERANCE IN WHEAT: RESPONSES, MECHANISMS AND ADAPTATION APPROACHES
SALINITY TOLERANCE IN WHEAT: RESPONSES, MECHANISMS AND ADAPTATION APPROACHES Open
Soil salinity is one of the most devastating environmental stresses, causing a significant reduction in cultivable land worldwide.Salinity restricts the growth, development, and yield of plants.In response to salinity, plants alter their m…
View article: Collagen Nanoparticle-Mediated Brain Silymarin Delivery: An Approach for Treating Cerebral Ischemia and Reperfusion-Induced Brain Injury
Collagen Nanoparticle-Mediated Brain Silymarin Delivery: An Approach for Treating Cerebral Ischemia and Reperfusion-Induced Brain Injury Open
Silymarin is a bioactive constituent isolated from milk thistle (Silybum marinum). Since its discovery, silymarin has been considered a gold standard drug in treating ailments related to the liver, resulting from alcohol consumption…
View article: Emergence of a New Zoonotic COVID-19 that Creates a Pandemic: Update on Current Pharmacotherapeutics and Future Prospective of Plasma Therapy
Emergence of a New Zoonotic COVID-19 that Creates a Pandemic: Update on Current Pharmacotherapeutics and Future Prospective of Plasma Therapy Open
The current decade started on an unexpected note, with almost the entire world grappling with a newly arisen pandemic. A novel coronavirus, tracing its first human host to a Chinese province, has spread to all geographical areas with human…
View article: Diabetic kidney disease: An overview of prevalence, risk factors, and biomarkers
Diabetic kidney disease: An overview of prevalence, risk factors, and biomarkers Open
View article: Collagen–curcumin nanocomposites showing an enhanced neuroprotective effect against short term focal cerebral ischemia
Collagen–curcumin nanocomposites showing an enhanced neuroprotective effect against short term focal cerebral ischemia Open
A synthetic collagen–curcumin nanocomposite enhanced drug efficacy by increasing its bioavailability and showing slow and sustained drug release in the treatment against focal cerebral ischemia.
View article: Nicotinamide Therapy in Dialysis Patients: A Systematic Review of Randomized Controlled Trials
Nicotinamide Therapy in Dialysis Patients: A Systematic Review of Randomized Controlled Trials Open
Randomized controlled trials (RCTs) have presented variable findings concerning the reduction of phosphorous level by nicotinamide. This systematic review is aimed to explore the safety and efficacy of nicotinamide in hemodialysis patients…
View article: Protective effects of alendronate in Triton X-100-induced hyperlipidemia in rats
Protective effects of alendronate in Triton X-100-induced hyperlipidemia in rats Open
Alendronate showed dose-dependent antihyperlipidemic and hepatoprotective effects. It may serve a dual purpose as anti-osteoporotic and hypolipidemic by reducing blood cholesterol and TG synthesis and offering hepatic protection.
View article: Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer’s disease
Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer’s disease Open
With the constant failure of the clinical trials continuous exploration of a therapeutic target against Alzheimer's disease (AD) is the utmost need. Numerous studies have supported the hypothesis that central insulin resistance plays a sig…
View article: Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2–ARE pathway
Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2–ARE pathway Open
We have investigated a novel mechanism of action for rosuvastatin (via the Nrf2-ARE pathway) and demonstrated that it has the potential to be used in the treatment of cognitive impairment.
View article: HEPATOPROTECTIVE EFFECTS OF PUNICA GRANATUM FRUIT AGAINST D-GALACTOSAMINE-INDUCED HEPATOTOXICITY IN RATS: IN VITRO AND IN VIVO STUDIES
HEPATOPROTECTIVE EFFECTS OF PUNICA GRANATUM FRUIT AGAINST D-GALACTOSAMINE-INDUCED HEPATOTOXICITY IN RATS: IN VITRO AND IN VIVO STUDIES Open
Objective: Hepatoprotective activity of Punica granatum Linn. (Family: Punicaceae) was evaluated by in vitro and in vivo model. HepG2 cell lines were used for in vitro study and D-Galactosamine (D-GalN) induced hepatic damage model for in …
View article: Nigella sativa protects against isoproterenol-induced myocardial infarction by alleviating oxidative stress, biochemical alterations and histological damage
Nigella sativa protects against isoproterenol-induced myocardial infarction by alleviating oxidative stress, biochemical alterations and histological damage Open
Objective: To evaluate the cardioprotective effect of Nigella sativa L. (N. sativa) in isoproterenol-induced myocardial infarction (MI). Methods: Groups were treated with different doses of ethanol extract of N. sativa (EENS) and N. sativa…
View article: Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain
Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain Open
Lupeol, a natural active constituent of Betula alnoides (BA), is well known for its anti-inflammatory, anti-oxidant and neuroprotective activities. In present study the therapeutic potential of lupeol was investigated against amyloid beta …
View article: Protective Effect of Guggulipid in High Fat Diet and Middle Cerebral Artery Occlusion (MCAO) Induced Ischemic Cerebral Injury in Rats
Protective Effect of Guggulipid in High Fat Diet and Middle Cerebral Artery Occlusion (MCAO) Induced Ischemic Cerebral Injury in Rats Open
Guggulipid demonstrated neuroprotection owing to its hypolipidemic, antioxidant, anti-inflammatory and anti-thrombotic activities but further research is warranted to confirm its role in cerebral ischemia.
View article: Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage
Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage Open
Objectives: In the present study, we investigated whether combination therapy of low-dose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (…
View article: DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING IN URINARY TRACT INFECTION PATIENTS IN A TERTIARY CARE HOSPITAL
DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING IN URINARY TRACT INFECTION PATIENTS IN A TERTIARY CARE HOSPITAL Open
Background: Urinary tract infection is a key public health issue causing morbidity, especially in women population. This problem is further aggravated in pregnant women. Aims:This study was designed to evaluate the drug prescribing behavio…