Abdulaziz Alamri
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View article: Genome-Wide Discovery and Characterization of the Auxin Response Factor (ARF) Gene Family in Avicennia marina That Regulates Phytohormone Levels and Responds to Salt and Auxin Treatments
Genome-Wide Discovery and Characterization of the Auxin Response Factor (ARF) Gene Family in Avicennia marina That Regulates Phytohormone Levels and Responds to Salt and Auxin Treatments Open
Auxin response factors (ARFs) are crucial components of auxin signaling, playing a vital role in plant growth, development, hormone regulation, and stress responses. Salinity influences plant growth and development; however, Avicennia mari…
View article: Revolutionizing and identifying the mechanism of Rauwolfia Vomitoria against ovarian cancer: Molecular docking and network pharmacology
Revolutionizing and identifying the mechanism of Rauwolfia Vomitoria against ovarian cancer: Molecular docking and network pharmacology Open
View article: Multi-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability
Multi-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability Open
These findings contribute to the understanding of PIAS family genes in HNSC pathogenesis, diagnosis, prognosis, and potential therapeutic targeting.
View article: Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle
Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle Open
View article: Potential of Banana peel extract powder as a promising alternative to antibiotics for treating Salmonella Gallinarum infection in broiler chicks
Potential of Banana peel extract powder as a promising alternative to antibiotics for treating Salmonella Gallinarum infection in broiler chicks Open
With the global rise in antibiotic resistance, exploring plants for their potential as safe and natural alternatives to antimicrobials in poultry has become increasingly important. The present study aimed to evaluate the ethnoveterinary su…
View article: Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression
Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression Open
View article: COL1A1, ITGB1, THY1, and PDGFRA: key immune-related genes in uterine corpus endometrial carcinoma with prognostic and therapeutic implications
COL1A1, ITGB1, THY1, and PDGFRA: key immune-related genes in uterine corpus endometrial carcinoma with prognostic and therapeutic implications Open
Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies, characterized by complex molecular alterations that drive its progression. Understanding the molecular mechanisms underlying UCEC is crucial …
View article: Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms Open
View article: Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation
Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation Open
View article: New Curcumin Analogue (PAC) Inhibits Candida albicans Virulence, Restricts Its Adhesion Potential, and Relieves Oral Epithelial Cell Inflammation and Defense Mechanisms
New Curcumin Analogue (PAC) Inhibits Candida albicans Virulence, Restricts Its Adhesion Potential, and Relieves Oral Epithelial Cell Inflammation and Defense Mechanisms Open
Objectives: The oral cavity hosts one of the most complex microbial communities in the body. A disruption of the balance favors the growth of pathogenic species, contributing to oral diseases. The rise in microbial resistance has limited t…
View article: Anti-Virulence Properties of Curcumin/CuO-NPs and Their Role in Accelerating Wound Healing In Vivo
Anti-Virulence Properties of Curcumin/CuO-NPs and Their Role in Accelerating Wound Healing In Vivo Open
Background and Objectives: This study introduces an innovative approach to accelerating wound healing by leveraging the bactericidal properties of mycosynthesized copper oxide nanoparticles (CuO-NPs) and their combination with curcumin aga…
View article: Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation
Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation Open
Tuberculosis (TB) remains a major global health concern, with the transition from latent to active TB still poorly understood. Therefore, enhancing clinical management and prevention strategies for TB is essential. High-throughput sequenci…
View article: Gender-Based Differences in Stroke Types and Risk Factors Among Young Adults: A Comparative Retrospective Analysis
Gender-Based Differences in Stroke Types and Risk Factors Among Young Adults: A Comparative Retrospective Analysis Open
Background/Objectives: Stroke is considered the second-leading cause of mortality and a primary contributor to adult disability among both men and women. The primary aim of this research is to conduct a comprehensive investigation into gen…
View article: Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients
Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients Open
This study reveals the pivotal role of autoimmune gene dysregulation in BC progression and immune microenvironment remodeling. Integrating autoimmune gene signatures with transcriptomic data provides novel insights into BC pathogenesis and…
View article: CD8+ CD103+ regulatory T cells attenuate desiccating stress-induced dry eye disease by suppressing CD4+ T cell-mediated inflammation and preserving ocular surface integrity in mice
CD8+ CD103+ regulatory T cells attenuate desiccating stress-induced dry eye disease by suppressing CD4+ T cell-mediated inflammation and preserving ocular surface integrity in mice Open
CD8+CD103+ T cells exert immunomodulatory and tissue-protective effects in DS-induced DED by suppressing pathogenic CD4+ T cell responses and restoring a favorable cytokine balance. These findings highlight…
View article: Exploring the critical role of SDHA in breast cancer proliferation: implications for novel therapeutic strategies
Exploring the critical role of SDHA in breast cancer proliferation: implications for novel therapeutic strategies Open
SDHA was upregulated in breast cancer and associated with poor prognosis. Our findings also suggest that SDHA plays a crucial role in promoting breast cancer cell growth and migration, indicating its therapeutic potential. Targeting SDHA c…
View article: Biophysical Insights into the Interaction of Zwitterionic Surfactant (Sulfobetaine 10) with Aggregation-Prone Protein
Biophysical Insights into the Interaction of Zwitterionic Surfactant (Sulfobetaine 10) with Aggregation-Prone Protein Open
Protein misfolding and aggregation play crucial roles in several neurodegenerative disorders. In this study, sulfobetaine-10 (SB10) has been demonstrated to stabilize proteins and inhibit aggregation by preserving solubility and retaining …
View article: Preparation and characterization of lemongrass oil nanoemulsion: Antimicrobial, antibiofilm, antioxidant, and anticancer activities
Preparation and characterization of lemongrass oil nanoemulsion: Antimicrobial, antibiofilm, antioxidant, and anticancer activities Open
Although citrus essential oils, including lemongrass essential oil, have antibacterial, anti-biofilm, and antioxidant properties, their biological instability and poor water solubility render them unsuitable for industrial usage. Thus, thi…
View article: Protective Effects of Olive Leaf Extract as a Natural Growth Promoter and Immune Modulator in Broilers Challenged with Velogenic Newcastle Disease Virus
Protective Effects of Olive Leaf Extract as a Natural Growth Promoter and Immune Modulator in Broilers Challenged with Velogenic Newcastle Disease Virus Open
Newcastle disease (ND) is a serious menace to poultry production and requires stringent measures to enhance growth and improve resistance against viral challenges in infected flocks. In the present study, the immunostimulatory and growth-p…
View article: Novel trimetallic (TiO <sub>2</sub> –MgO–Au) nanoparticles: Biosynthesis, characterization, antimicrobial, and anticancer activities
Novel trimetallic (TiO <sub>2</sub> –MgO–Au) nanoparticles: Biosynthesis, characterization, antimicrobial, and anticancer activities Open
Trimetallic nanoparticles have garnered significant attention due to their promising biological activities. In this study, the aqueous extract of banana peel was utilized as a reducing and stabilizing agent for the green synthesis of novel…
View article: Coomassie Brilliant Blue Induces Coiled-Coil Aggregation in Lysozyme at pH 7.4 by Hydrophobic and Electrostatic Forces
Coomassie Brilliant Blue Induces Coiled-Coil Aggregation in Lysozyme at pH 7.4 by Hydrophobic and Electrostatic Forces Open
Several neurodegenerative diseases are associated with the deposition of amyloid fibrils. Although these diseases are irreversible, knowing the aggregation mechanism is useful in developing drugs that can arrest or decrease the aggregation…
View article: Multispectroscopic and computational insights into amyloid fibril formation of alpha lactalbumin induced by sodium hexametaphosphate
Multispectroscopic and computational insights into amyloid fibril formation of alpha lactalbumin induced by sodium hexametaphosphate Open
The impact of sodium hexametaphosphate (SHMP) on the aggregation behavior of α-lactalbumin (α-LA) was studied at pH 7.4 and 2.0. Turbidity measurements showed a concentration-dependent aggregation of α-LA at pH 2.0 in the presence of SHMP,…
View article: Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2
Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2 Open
The coronavirus that causes serious acute respiratory syndrome. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a major problem in public health and biomedicine. Even if there is no cure for it, the infection is still…
View article: In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions
In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions Open
Herbs have been used as medicines since antiquity, and it has been discovered that the human body responds well to herbal remedies. Research on the effect of butin was conducted in the current study in the alloxan-induced diabetic rat para…
View article: 6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway
6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway Open
Background Huntington’s disease (HD) is an extremely harmful autosomal inherited neurodegenerative disease. Motor dysfunction, mental disorder, and cognitive deficits are the characteristic features of this disease. The current study exami…
View article: Phytochemical screening, antioxidant, immunomodulatory and analgesic potential of aqueous-ethanolic extracts of Euphorbia prostrata ait. and Crotalaria burhia Buch–Ham
Phytochemical screening, antioxidant, immunomodulatory and analgesic potential of aqueous-ethanolic extracts of Euphorbia prostrata ait. and Crotalaria burhia Buch–Ham Open
View article: Bridging the Gaps: The Transformative Effect of Coronavirus Disease 2019 (COVID-19) on Preventive Measures Among Medical and Health Sciences College Students in Madinah, Saudi Arabia
Bridging the Gaps: The Transformative Effect of Coronavirus Disease 2019 (COVID-19) on Preventive Measures Among Medical and Health Sciences College Students in Madinah, Saudi Arabia Open
Background The global impact of coronavirus disease 2019 (COVID-19) has disrupted the activities of medical and health profession education institutions. This study aimed to determine the impact of COVID-19 on medical and health profession…
View article: Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile
Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile Open
Oral cancer is considered as one of the most common malignancies worldwide. Its conventional treatment primarily involves surgery with or without postoperative adjuvant therapy. The targeting of signaling pathways implicated in tumorigenes…
View article: Hexametaphosphate, a Common Food Additive, Aggregated the Hen Egg White Lysozyme
Hexametaphosphate, a Common Food Additive, Aggregated the Hen Egg White Lysozyme Open
Polyphosphate polymers are chains of phosphate monomers chemically bonded together via phosphoanhydride bonds. They are found in all prokaryotic and eukaryotic organisms and are among the earliest, most anionic, and most mysterious molecul…
View article: Interaction Mechanism between α-Lactalbumin and Caffeic Acid: A Multispectroscopic and Molecular Docking Study
Interaction Mechanism between α-Lactalbumin and Caffeic Acid: A Multispectroscopic and Molecular Docking Study Open
Caffeic acid (CA) is a phenolic acid found in a variety of foods. In this study, the interaction mechanism between α-lactalbumin (ALA) and CA was explored with the use of spectroscopic and computational techniques. The Stern-Volmer quenchi…