Mai M. El-Daly
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View article: Human papillomavirus genotypes in Jeddah, Saudi Arabia: prevalence and public health implications
Human papillomavirus genotypes in Jeddah, Saudi Arabia: prevalence and public health implications Open
These findings highlight the importance of continued surveillance, targeted vaccination efforts, and improved screening programs in Saudi Arabia. Increasing awareness of HPV and enhancing vaccination rates, especially among younger age gro…
View article: Electrochemical Performance of Hydrothermal Synthesized Fe<sub>3</sub>O<sub>4</sub>/ReS<sub>2</sub> Heterostructure for Supercapacitor Electrodes
Electrochemical Performance of Hydrothermal Synthesized Fe<sub>3</sub>O<sub>4</sub>/ReS<sub>2</sub> Heterostructure for Supercapacitor Electrodes Open
Developing materials for electrodes with engineered interfaces is important for improving supercapacitor performance. Combining metal oxides and two-dimensional (2D) transition-metal dichalcogenides (TMDs) is a promising approach to develo…
View article: TNF-α mRNA expression as a shared molecular marker in primary hyperparathyroidism and systemic lupus erythematosus: a new perspective on osteoimmunology
TNF-α mRNA expression as a shared molecular marker in primary hyperparathyroidism and systemic lupus erythematosus: a new perspective on osteoimmunology Open
Background Tumor necrosis factor-α (TNF-α) is an immune regulator, involved in the pathogenesis of numerous diseases, such as systemic lupus erythematosus (SLE). Primary hyperparathyroidism (PHPT) is an endocrinopathy recognized by the hyp…
View article: Putative herbal drugs for targeting infection and inflammatory diseases: Network pharmacological application in case of Zika virus and Dengue virus infections
Putative herbal drugs for targeting infection and inflammatory diseases: Network pharmacological application in case of Zika virus and Dengue virus infections Open
Inflammation is the primary cause of many human diseases, including the Zika virus, Dengue infection, COVID-19 infection, asthma, rheumatoid arthritis, inflammatory bowel disease, Crohn’s disease, and tendinitis. Other diseases that are cl…
View article: Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational study
Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational study Open
The Zika virus (ZIKV), a member of the Flaviviridae family, has caused multiple widespread outbreaks, posing significant challenges to global health. This study explores the potential of compounds from Echinacea angustifolia ( E. angustifo…
View article: Study of the Prevalence of Human Papillomavirus Genotypes in Jeddah, Saudi Arabia
Study of the Prevalence of Human Papillomavirus Genotypes in Jeddah, Saudi Arabia Open
Human papillomavirus (HPV), a common sexually transmitted infection, includes over 200 types, some linked to genital warts and various cancers, including cervical, anal, penile, and oropharyngeal cancers. In Saudi Arabia, an estimated 10.7…
View article: T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene Expression as a Negative Biomarker of B-Cell Acute Lymphoblastic Leukemia
T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene Expression as a Negative Biomarker of B-Cell Acute Lymphoblastic Leukemia Open
B-cell acute lymphoblastic leukemia (B-ALL) accounts for 85% of all childhood ALL. Malignancies exhaust T and B cells, resulting in an increased expression of immune checkpoint receptors (ICRs), such as T-cell immunoglobulin and mucin doma…
View article: Immunological and molecular assessment of HIV-1 mutations for antiretroviral drug resistance in Saudi Arabia
Immunological and molecular assessment of HIV-1 mutations for antiretroviral drug resistance in Saudi Arabia Open
Human Immunodeficiency Virus (HIV) is a significant threat to public health. HIV genotyping and antiretroviral resistance testing may have contributed to improved non-treated management. Immune markers might assist HIV-1 diagnosis and drug…
View article: Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia
Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia Open
Herpesvirus entry mediator (HVEM) is a molecular switch that can modulate immune responses against cancer. The significance of HVEM as an immune checkpoint target and a potential prognostic biomarker in malignancies is still controversial.…
View article: Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies
Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies Open
The urgent need for accurate COVID-19 diagnostics has led to the development of various SARS-CoV-2 detection technologies. Real-time reverse transcriptase polymerase chain reaction (RT-qPCR) remains a reliable viral gene detection techniqu…
View article: A Multifaceted Computational Approach to Understanding the MERS-CoV Main Protease and Brown Algae Compounds’ Interaction
A Multifaceted Computational Approach to Understanding the MERS-CoV Main Protease and Brown Algae Compounds’ Interaction Open
Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused b a special type of coronavirus called MERS-CoV. In the search for effective substances against the MERS-CoV main protease, we looked into compounds from brown a…
View article: A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus
A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus Open
Monkeypox viral infection is an emerging threat and a major concern for the human population. The lack of drug molecules to treat this disease may worsen the problem. Identifying potential drug targets can significantly improve the process…
View article: Cheminformatics Strategies Unlock Marburg Virus VP35 Inhibitors from Natural Compound Library
Cheminformatics Strategies Unlock Marburg Virus VP35 Inhibitors from Natural Compound Library Open
The Ebola virus and its close relative, the Marburg virus, both belong to the family Filoviridae and are highly hazardous and contagious viruses. With a mortality rate ranging from 23% to 90%, depending on the specific outbreak, the develo…
View article: Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase
Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase Open
The World Health Organization (WHO) has designated the Zika virus (ZIKV) as a significant risk to the general public’s health. Currently, there are no vaccinations or medications available to treat or prevent infection with the Zika virus.…
View article: Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm
Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm Open
The body’s normal immune response against any invading pathogen that causes infection in the body results in inflammation. The sudden transformation in inflammation leads to the rise of inflammatory diseases such as chronic inflammatory bo…
View article: Analysis of the nasopharyngeal microbiome and respiratory pathogens in COVID-19 patients from Saudi Arabia
Analysis of the nasopharyngeal microbiome and respiratory pathogens in COVID-19 patients from Saudi Arabia Open
Overall, no substantial difference was observed in the predominant NP bacterial community, but specific taxa were significantly changed between the healthy control and COVID-19 patients. Comparatively, an increased number of respiratory pa…
View article: Hepatitis E Virus (HEV) in Makkah, Saudi Arabia: A Population-Based Seroprevalence Study
Hepatitis E Virus (HEV) in Makkah, Saudi Arabia: A Population-Based Seroprevalence Study Open
Background: The Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Little is known about the seroprevalence of HEV in the general population of Saudi Arabia. Methods: A community-based cross-sectional HEV seroprevalenc…
View article: Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma
Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma Open
Data integration with phenotypes such as gene expression, pathways or function, and protein-protein interactions data has proven to be a highly promising technique for improving human complex diseases, particularly cancer patient outcome p…
View article: Identification of Antiviral Compounds against Monkeypox Virus Profilin-like Protein A42R from Plantago lanceolata
Identification of Antiviral Compounds against Monkeypox Virus Profilin-like Protein A42R from Plantago lanceolata Open
Infections caused by the monkeypox virus (MPXV) have continued to be transmitted significantly in recent years. However, understanding the transmission mechanism, risk factors, and consequences of infection are still limited. Structure-bas…
View article: Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus
Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus Open
The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes viral encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA-dependent RNA polymerase (RdRp) present in the viral genome is t…
View article: Virtual screening and molecular dynamics simulation analysis of Forsythoside A as a plant-derived inhibitor of SARS-CoV-2 3CLpro
Virtual screening and molecular dynamics simulation analysis of Forsythoside A as a plant-derived inhibitor of SARS-CoV-2 3CLpro Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a more severe strain of coronavirus (CoV) that was first emerged in China in 2019. Available antiviral drugs could be repurposed and natural compounds with antiviral activity …
View article: Active viral shedding in a vaccinated hospitalized patient infected with the delta variant (B.1.617.2) of SARS-CoV-2 and challenges of de-isolation
Active viral shedding in a vaccinated hospitalized patient infected with the delta variant (B.1.617.2) of SARS-CoV-2 and challenges of de-isolation Open
In the era of SARS-CoV-2 variants and COVID-19 vaccination, the duration of infectious viral shedding and isolation in post vaccine breakthrough infections is challenging and depends on disease severity. The current study described a case …
View article: Rapid and Reliable Detection of SARS-CoV-2 Using Direct RT-LAMP
Rapid and Reliable Detection of SARS-CoV-2 Using Direct RT-LAMP Open
Background: The global pandemic coronavirus SARS-CoV-2 has a healthcare, social and economic burden. To limit the spread of the virus, the World Health Organization (WHO) urgently called for extensive screening of suspected individuals; th…
View article: Hepatitis E Virus (HEV) in Imported and Domestic Camels in Saudi Arabia – A Cross-Sectional Descriptive Molecular Study
Hepatitis E Virus (HEV) in Imported and Domestic Camels in Saudi Arabia – A Cross-Sectional Descriptive Molecular Study Open
Camels gained attention since the discovery of MERS-CoV as intermediary hosts for potentially epidemic zoonotic viruses. DcHEV is a novel zoonotic pathogen associated with camel contact. This study aimed to genetically characterize DcHEV i…
View article: Insulin Growth Factor-1 as a Predictor for the Progression of Hepatic Disease in Chronic Hepatitis B Virus Infection
Insulin Growth Factor-1 as a Predictor for the Progression of Hepatic Disease in Chronic Hepatitis B Virus Infection Open
Background & Aims: The aim of this study was to assess IGF-1 in chronic liver diseases associated with HBV infection and describe the impact of liver status on IGF-1 variables. Methods: This cohort study included 348 subjects and conducted…