Mohammed Ayed Huneif
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View article: Retraction notice to "Phytochemical composition and bioactivities of Crataegus aronia as antioxidant, antibacterial and antioxidative stress in red blood cells – Is it a window of hope for children with glucose-6-phosphate dehydrogenase deficiency" [Heliyon 8 (2022) e11516]
Retraction notice to "Phytochemical composition and bioactivities of Crataegus aronia as antioxidant, antibacterial and antioxidative stress in red blood cells – Is it a window of hope for children with glucose-6-phosphate dehydrogenase deficiency" [Heliyon 8 (2022) e11516] Open
[This retracts the article DOI: 10.1016/j.heliyon.2022.e11516.].
View article: A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management
A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management Open
Insulin is the main metabolic regulator of fuel molecules in the diet, such as carbohydrates, lipids, and proteins. It does so by facilitating glucose influx from the circulation into the liver, adipose tissue, and skeletal myocytes. The o…
View article: Exploration of Succinimide Derivative as a Multi-Target, Anti-Diabetic Agent: In Vitro and In Vivo Approaches
Exploration of Succinimide Derivative as a Multi-Target, Anti-Diabetic Agent: In Vitro and In Vivo Approaches Open
Diabetes mellitus (DM) is counted among one of the leading challenges in the recent era, and it is a life-threatening disorder. Compound 4-hydroxy 3-methoxy phenylacetone (compound 1) was previously isolated from Polygonum aviculare. This …
View article: New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies
New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies Open
Diabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of the pancreas manifested as a decline in the insulin production or the tissue’s resistance to the insulin. In this research, we have rationally desig…
View article: Diagnostic Validity and Reliability of Low-Dose Prospective ECG-Triggering Cardiac CT in Preoperative Assessment of Complex Congenital Heart Diseases (CHDs)
Diagnostic Validity and Reliability of Low-Dose Prospective ECG-Triggering Cardiac CT in Preoperative Assessment of Complex Congenital Heart Diseases (CHDs) Open
For the precise preoperative evaluation of complex congenital heart diseases (CHDs) with reduced radiation dose exposure, we assessed the diagnostic validity and reliability of low-dose prospective ECG-gated cardiac CT (CCT). Forty-two ind…
View article: A Turf-Based Feature Selection Technique for Predicting Factors Affecting Human Health during Pandemic
A Turf-Based Feature Selection Technique for Predicting Factors Affecting Human Health during Pandemic Open
Worldwide, COVID-19 is a highly contagious epidemic that has affected various fields. Using Artificial Intelligence (AI) and particular feature selection approaches, this study evaluates the aspects affecting the health of students through…
View article: Phytochemicals As a Potential Inhibitor of COVID-19: An In-Silico Perspective
Phytochemicals As a Potential Inhibitor of COVID-19: An In-Silico Perspective Open
The current research has centered on the use of pharmacological and binding affinity methods to test the 36 compounds as bioactive constituents’ inhibitors for COVID-19. Six compounds out of 36 phytoconstituents (rutin, quercetin, catechin…
View article: α-Glucosidase, α-Amylase and Antioxidant Evaluations of Isolated Bioactives from Wild Strawberry
α-Glucosidase, α-Amylase and Antioxidant Evaluations of Isolated Bioactives from Wild Strawberry Open
Diabetes mellitus is a metabolic disorder and is a global challenge to the current medicinal chemists and pharmacologists. This research has been designed to isolate and evaluate antidiabetic bioactives from Fragaria indica. The crude extr…
View article: 3-(((1S,3S)-3-((R)-Hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-oxocyclohexyl)methyl)pentane-2,4-dione: Design and Synthesis of New Stereopure Multi-Target Antidiabetic Agent
3-(((1S,3S)-3-((R)-Hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-oxocyclohexyl)methyl)pentane-2,4-dione: Design and Synthesis of New Stereopure Multi-Target Antidiabetic Agent Open
The chiral drug candidates have more effective binding affinities for their specific protein or receptor site for the onset of pharmacological action. Achieving all carbon stereopure compounds is not trivial in chemical synthesis. However,…
View article: Design, synthesis and bioevaluation of new vanillin hybrid as multitarget inhibitor of α-glucosidase, α-amylase, PTP-1B and DPP4 for the treatment of type-II diabetes
Design, synthesis and bioevaluation of new vanillin hybrid as multitarget inhibitor of α-glucosidase, α-amylase, PTP-1B and DPP4 for the treatment of type-II diabetes Open
Diabetes mellitus (DM) is a real challenge to the recent era and is one of the major diseases for initiating life-threatening disorders. In current research, a compound was designed by combining vanillin, thiazolidinedione and morpholine. …
View article: In Silico Molecular Docking and Simulation Studies of Protein HBx Involved in the Pathogenesis of Hepatitis B Virus-HBV
In Silico Molecular Docking and Simulation Studies of Protein HBx Involved in the Pathogenesis of Hepatitis B Virus-HBV Open
Current drug discovery involves finding leading drug candidates for further development. New scientific approaches include molecular docking, ADMET studies, and molecular dynamic simulation to determine targets and lead compounds. Hepatiti…
View article: The association between leptin levels with glycemic control, body mass index, and progression of HbA1c values in type 1 diabetic children in Southwestern Saudi Arabia
The association between leptin levels with glycemic control, body mass index, and progression of HbA1c values in type 1 diabetic children in Southwestern Saudi Arabia Open
Background: Diabetes mellitus is a widespread serious metabolic disease with both short and long-term complications.Leptin is a polypeptide hormone, exclusively secreted from adipose tissue and its level is directly proportional to the amo…
View article: The efficiency of some active ingredients of Arum Palaestinum as inhibitors to 3CLpro and Nsp15 proteins
The efficiency of some active ingredients of Arum Palaestinum as inhibitors to 3CLpro and Nsp15 proteins Open
Two active coronaviral proteins (3CL pro and Nsp15) have been studied using both the GC-MS and docking methods.These coronaviral proteins have been examined with the methanol extract generated from leaves of the Arum palaestinum.According …
View article: Preparation of Spice Extracts: Evaluation of Their Phytochemical, Antioxidant, Antityrosinase, and Anti‐<i>α</i>‐Glucosidase Properties Exploring Their Mechanism of Enzyme Inhibition with Antibrowning and Antidiabetic Studies <i>In Vivo</i>
Preparation of Spice Extracts: Evaluation of Their Phytochemical, Antioxidant, Antityrosinase, and Anti‐<i>α</i>‐Glucosidase Properties Exploring Their Mechanism of Enzyme Inhibition with Antibrowning and Antidiabetic Studies <i>In Vivo</i> Open
Tyrosinase and α ‐glucosidase enzymes are known as promising target candidates for inhibitors to control unwanted pigmentation and type II diabetics mellitus. Therefore, twenty extracts as enzyme inhibitors were prepared from edible spices…
View article: Automated Speech Recognition System to Detect Babies’ Feelings through Feature Analysis
Automated Speech Recognition System to Detect Babies’ Feelings through Feature Analysis Open
Diagnosing a baby's feelings poses a challenge for both doctors and parents because babies cannot explain their feelings through expression or speech. Understanding the emotions of babies and their associated expressions during different s…
View article: Analyzing the Features Affecting the Performance of Teachers during Covid-19: A Multilevel Feature Selection
Analyzing the Features Affecting the Performance of Teachers during Covid-19: A Multilevel Feature Selection Open
COVID-19 is a profoundly contagious pandemic that has taken the world by storm and has afflicted different fields of life with negative effects. It has had a substantial impact on education which is evident from the transition from Face-to…
View article: Influence of Ramadan Fasting on Hemoglobin A1C, Lipid Profile, and Body Mass Index among Type 2 Diabetic Patients in Najran City, Saudi Arabia
Influence of Ramadan Fasting on Hemoglobin A1C, Lipid Profile, and Body Mass Index among Type 2 Diabetic Patients in Najran City, Saudi Arabia Open
BACKGROUND: Saudi Arabia is known to have one of the highest prevalence of diabetes in the world. The impact of Ramadan fasting on the health of type 2 diabetic patients is an important issue that has not been adequately investigated. AIM:…
View article: A Perspective in Antenatal Care: A Short Emphasis on Hydration, Essential Fatty Acids and Micronutrients
A Perspective in Antenatal Care: A Short Emphasis on Hydration, Essential Fatty Acids and Micronutrients Open
Antenatal care of women is a vital issue with regards to health promotion for forthcoming infants.This type of medical care should start before the onset of a pregnancy.Antenatal care facilitates early and continuous assessment of the pote…
View article: A Novel SCNN1A Variation in a Patient with Autosomal-recessive Pseudohypoaldosteronism Type 1
A Novel SCNN1A Variation in a Patient with Autosomal-recessive Pseudohypoaldosteronism Type 1 Open
Pseudohypoaldosteronism type 1 (PHA1) is an autosomal-recessive disorder characterized by defective regulation of body sodium (Na) levels. The abnormality results from mutations in the genes encoding subunits of the epithelial Na channel. …
View article: The Impact of COVID-19 Pandemic Lockdown on the Incidence of New-Onset Type 1 Diabetes and Ketoacidosis Among Saudi Children
The Impact of COVID-19 Pandemic Lockdown on the Incidence of New-Onset Type 1 Diabetes and Ketoacidosis Among Saudi Children Open
Background Overburdened healthcare systems during the coronavirus disease (COVID-19) pandemic led to suboptimal chronic disease management, including that of pediatric type 1 diabetes mellitus (T1DM). The pandemic also caused delayed detec…
View article: 'Micro-terrorism': COVID-19 Makes the Horrible Face of Microbiology
'Micro-terrorism': COVID-19 Makes the Horrible Face of Microbiology Open
Micro-terrorism! We coin this term to show the horrible face of microbiology in a way similar to the current widespread terrorism throughout the world. Throughout the ages, tiny organisms were the immediate cause of devastating epidemics t…
View article: A Retrospective Evaluation of Cutaneous Adverse Drug Reactions (CADRs) Due to Antibiotics Using Naranjo Adverse Drug Reactions (ADRs) Probability Scale
A Retrospective Evaluation of Cutaneous Adverse Drug Reactions (CADRs) Due to Antibiotics Using Naranjo Adverse Drug Reactions (ADRs) Probability Scale Open
: Cutaneous adverse drug reactions (CADRs) have been found to be one of the most common adverse drug reactions (ADRs) in many studies. There is no common globally accepted tool for causality grading of ADRs to be utilized in pharmacovigila…
View article: Diagnosis and Management of Systemic Lupus Erythematosus: A Case Report
Diagnosis and Management of Systemic Lupus Erythematosus: A Case Report Open
Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease with a broad clinical presentation, which is principally difficult to diagnose across the emergency departments (EDs). The immune system of the body in this disease m…
View article: Distribution of Thyroid Autoantibodies in Saudi Children with Type 1 DM and their Effect on Glycemic Control
Distribution of Thyroid Autoantibodies in Saudi Children with Type 1 DM and their Effect on Glycemic Control Open
Introduction Type1 diabetes mellitus (T1DM) is a chronic autoimmune disease result in destruction of pancreatic beta cells lead to the clinical form of the disease (1). Unfortunately a recent study reported increasing in the incidence of t…
View article: Diagnosis and Management of Systemic Lupus Erythematosus: A Case Report
Diagnosis and Management of Systemic Lupus Erythematosus: A Case Report Open
Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease with a broad clinical presentation, which is principally difficult to diagnose across the emergency departments (EDs). The immune system of the body in this disease m…