Ammar Ahmed
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View article: Insulin Versus Established GLP-1 Receptor Agonists, DPP-4 Inhibitors, and SGLT-2 Inhibitors for Uncontrolled Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Insulin Versus Established GLP-1 Receptor Agonists, DPP-4 Inhibitors, and SGLT-2 Inhibitors for Uncontrolled Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Limited head-to-head studies compare established glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase-4 inhibitors (DPP-4is), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) to insulin in the management of …
View article: Frequency of Surgically Induced Astigmatism after Phacoemulsification
Frequency of Surgically Induced Astigmatism after Phacoemulsification Open
Background: Cataract is the leading cause of avoidable blindness worldwide, and phacoemulsification is now the preferred surgical technique due to its superior visual and refractive outcomes compared to older methods. Despite these advanta…
View article: Clinical and Electrophysiological Outcomes of Left Bundle Area Pacing Compared to Biventricular Pacing: An Updated Meta-analysis
Clinical and Electrophysiological Outcomes of Left Bundle Area Pacing Compared to Biventricular Pacing: An Updated Meta-analysis Open
Left bundle branch area pacing (LBBAP) is a novel pacing strategy that uses the conduction system distal to the left bundle branch block level for direct activation of the left bundle and right ventricular myocardium. Our meta-analysis com…
View article: Uncovering the Invisible: The Role of High-density Catheters in Recognizing Fractionated Signals in Pulmonary Vein Isolation
Uncovering the Invisible: The Role of High-density Catheters in Recognizing Fractionated Signals in Pulmonary Vein Isolation Open
The HD Grid multipolar mapping catheter has emerged as an invaluable tool for greater effectiveness of pulmonary vein isolation (PVI). In the cases described here, fractionated signals seen with the HD Grid catheter at the left atrial appe…
View article: Spectrum of Hemoglobinopathies in Tertiary Care Hospitals of Rawalpindi and Islamabad
Spectrum of Hemoglobinopathies in Tertiary Care Hospitals of Rawalpindi and Islamabad Open
Hemoglobinopathies, including Thalassemia and sickle-cell syndromes are lifelong diseases with a significant impact on patients, families, and healthcare resources. Despite therapeutic progress, Pakistan, located within the Thalassemia bel…
View article: An Uncommon Focus of a Common Phenomenon: Superior Vena Cava Triggering Atrial Fibrillation
An Uncommon Focus of a Common Phenomenon: Superior Vena Cava Triggering Atrial Fibrillation Open
Ablation of atrial fibrillation most commonly involves the pulmonary veins; however, the superior vena cava (SVC) is an important potentially arrhythmogenic structure that should not be overlooked. This case report demonstrates an excellen…
View article: A serious complication of high-power short-duration radiofrequency atrial fibrillation ablation associated with genetic hypodysfibrinogenemia
A serious complication of high-power short-duration radiofrequency atrial fibrillation ablation associated with genetic hypodysfibrinogenemia Open
Cardiac tamponade is a rare and potentially fatal outcome in patients who undergo atrial fibrillation (AF) ablation1. In the US about 2.7 million are known to have AF, and of those approximately 0.8% undergo catheter ablation. Cardiac perf…
View article: Uncovering the Invisible: Role of High Density Catheters in recognizing fractionated signals in Pulmonary vein isolation.
Uncovering the Invisible: Role of High Density Catheters in recognizing fractionated signals in Pulmonary vein isolation. Open
The HD-grid multipolar mapping catheter has emerged as an invaluable tool for greater effectiveness of pulmonary vein isolation (PVI). In the cases described below, fractionated signals seen with the HD-grid catheter at the LAA and LSPV ju…
View article: Epicardial Potential in the Left Atrium During Posterior Wall Isolation in Persistent Atrial Fibrillation
Epicardial Potential in the Left Atrium During Posterior Wall Isolation in Persistent Atrial Fibrillation Open
Pulmonary vein isolation (PVI) is used for rhythm control in atrial fibrillation (AF). Posterior wall isolation (PWI) is often an adjunct to PVI. Successful PWI is limited by esophageal location, epicardial bridging signals, tissue thickne…
View article: CLINICAL AND ELECTROPHYSIOLOGICAL OUTCOMES OF LEFT BUNDLE AREA PACING COMPARED TO BI-VENTRICULAR PACING: AN UPDATED META-ANALYSIS
CLINICAL AND ELECTROPHYSIOLOGICAL OUTCOMES OF LEFT BUNDLE AREA PACING COMPARED TO BI-VENTRICULAR PACING: AN UPDATED META-ANALYSIS Open
The Left bundle branch area pacing (LBBAP) is a novel pacing strategy that utilizes the conduction system distal to the left bundle branch block level for direct activation of the left bundle and the right ventricular myocardium. Our meta-…
View article: Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degenerations
Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degenerations Open
Hereditary spinocerebellar degenerations (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include hereditary spastic paraplegia (HSP), cerebellar ataxia, and spinocerebellar…
View article: A novel homozygous mutation in TRAPPC9 gene causing autosomal recessive non-syndromic intellectual disability
A novel homozygous mutation in TRAPPC9 gene causing autosomal recessive non-syndromic intellectual disability Open
Background The etiology of intellectual disabilities is diverse and includes both genetic and environmental factors. The genetic causes of intellectual disabilities range from chromosomal aberrations to single gene disorders. The TRAPPC9 g…
View article: Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degeneration
Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degeneration Open
Hereditary spinocerebellar degenerative disorders (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include spastic paraplegia, spastic ataxia, cerebellar ataxia, and spinoce…
View article: Case Report: A New Family With Pontocerebellar Hypoplasia 10 From Sudan
Case Report: A New Family With Pontocerebellar Hypoplasia 10 From Sudan Open
Pontocerebellar hypoplasia type 10 (PCH10) is a very rare autosomal recessive neurodegenerative disease characterized by intellectual disability, microcephaly, severe developmental delay, pyramidal signs, mild cerebellar atrophy, and white…
View article: RETRACTED: Outcome of neurocritical disorders, a multicenter prospective cross‐sectional study
RETRACTED: Outcome of neurocritical disorders, a multicenter prospective cross‐sectional study Open
Background Patients with neurocritical disorders who require admission to intensive care units (ICUs) constitute about 10–15% of critical care cases. Objectives To study the outcome of neurocritical disorders in intensive care units. Metho…
View article: The pattern of neurocritical disorders in multicenter in Khartoum State November 2020 to January 2021
The pattern of neurocritical disorders in multicenter in Khartoum State November 2020 to January 2021 Open
Background Neurocritical care is a growing subspecialty. It concerns with the management of life‐threatening neurological disorders. There is limited information regarding epidemiological data, disease characteristics, variability of clini…
View article: Outcome of Neurocritical Disorders, A Multicenter Study from Sudan
Outcome of Neurocritical Disorders, A Multicenter Study from Sudan Open
Background:Patients with neurocritical disorders that require admission to intensive care units (ICUs) constitute about 10–15% of critical care cases.Objectives:To study the outcome of neurocritical disorders in intensive care units.Method…
View article: Insights into Clinical, Genetic, and Pathological Aspects of Hereditary Spastic Paraplegias: A Comprehensive Overview
Insights into Clinical, Genetic, and Pathological Aspects of Hereditary Spastic Paraplegias: A Comprehensive Overview Open
Hereditary spastic paraplegias (HSP) are a heterogeneous group of motor neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome which starts typically in the lower limbs. They can present as pure or compl…
View article: <i>Clostridioides difficile</i>: innovations in target discovery and potential for therapeutic success
<i>Clostridioides difficile</i>: innovations in target discovery and potential for therapeutic success Open
Considerable progress has been made in the development of new anti-CDI drug candidates. Nevertheless, a greater comprehension of CDI pathogenesis and host-microbe interactions is beginning to uncover potential novel therapeutic targets, wh…
View article: Involvement of ADGRV1 Gene in Familial Forms of Genetic Generalized Epilepsy
Involvement of ADGRV1 Gene in Familial Forms of Genetic Generalized Epilepsy Open
Background: Genetic generalized epilepsies (GGE) including childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures alone (GGE-TCS), are common types of epilep…
View article: Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia
Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia Open
Introduction: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurological entity that includes more than 80 disorders which share lower limb spasticity as a common feature. Abnormalities in multiple cellular pr…
View article: Coronary Embolism despite CHA₂DS₂-VASc Score of Zero: Should We Reconsider Anticoagulation?
Coronary Embolism despite CHA₂DS₂-VASc Score of Zero: Should We Reconsider Anticoagulation? Open
Coronary embolism (CE) is a rare but important cause of acute coronary syndrome. The most common source of emboli is considered to be infective endocarditis and atrial fibrillation. Various studies have estimated the prevalence of coronary…