Hizni Salih
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View article: Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by <scp>HBsAg</scp> Levels: A Cross‐Sectional Study
Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by <span>HBsAg</span> Levels: A Cross‐Sectional Study Open
Characterisation of people with hepatitis B (PwHB) remains limited, particularly regarding treatment status, disease severity and biomarker profiles. Quantitative hepatitis B surface antigen (qHBsAg) is a key predictor of response to emerg…
View article: Hepatitis B Virus ( <scp>HBV</scp> ) Treatment Eligibility in the <scp>UK</scp> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines
Hepatitis B Virus ( <span>HBV</span> ) Treatment Eligibility in the <span>UK</span> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines Open
Nucleos/tide analogue (NA) drugs are used for long‐term treatment of chronic hepatitis B virus (HBV) infection, with treatment eligibility criteria changing rapidly amidst globally evolving clinical guidelines. We aimed to quantify the pre…
View article: Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports
Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports Open
Objectives The ‘tumour, node, metastasis’ (TNM) classification of colorectal cancer (CRC) predicts prognosis and so is vital to consider in analyses of patterns and outcomes of care when using electronic health records. Unfortunately, it i…
View article: External validation of the COLOFIT colorectal cancer risk prediction model in the Oxford-FIT dataset: the importance of population characteristics and clinically relevant evaluation metrics
External validation of the COLOFIT colorectal cancer risk prediction model in the Oxford-FIT dataset: the importance of population characteristics and clinically relevant evaluation metrics Open
Background A faecal immunochemical test (FIT) result ≥ 10 µg/g is recommended in the UK to triage patients with symptoms of colorectal cancer (CRC) in primary care for urgent cancer investigation. The COLOFIT model combining FIT results wi…
View article: Representations of sustainable design context in calligraphy production
Representations of sustainable design context in calligraphy production Open
تَبرُز مُشكِلَة البَحث بِالتَّساؤُلِ الآتِي: ما تَمَثُّلات السِّياق التَّصمِيمِيّ المُستَدام في النِّتاجِ الخَطِّيّ؟ ويَهدُف البَحث لِكَشفِ هذه التَّمَثُّلات ضِمن حُدُود مَكانِيَّة لِلنِّتاجِ الخَطِّيِّ في كُلٍّ مِنَ العِراقِ، والسُّعُودِيَّة، وتُركِيا، وإِيران، وتَطَرَّقَ الإِطار النَّظَرِيّ لِمَوضُوعاتِ السِّياق.. المَعنَى والمَفهُ…
View article: Prevalence and histopathological features of Helicobacter pylori infection among patients undergoing upper endoscopy in Zakho City, Iraq during 2021–2023
Prevalence and histopathological features of Helicobacter pylori infection among patients undergoing upper endoscopy in Zakho City, Iraq during 2021–2023 Open
View article: THE MOLECULAR EFFECTS OF BIOSYNTHESIZED COLICIN ON PATHOGENIC BACTERIA
THE MOLECULAR EFFECTS OF BIOSYNTHESIZED COLICIN ON PATHOGENIC BACTERIA Open
Infectious diseases caused by pathogenic bacteria are recognized worldwide as a significant and pressing concern for human health. The misuse and overuse of antibiotics have further exacerbated the issue by giving rise to the emergence of …
View article: Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines
Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines Open
Objective Nucleos/tide analogue (NA) drugs are used for the long-term treatment of chronic hepatitis B virus (HBV) infection. In a landscape of changing clinical recommendations, we set out to quantify the prescription of NA drugs to date,…
View article: Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy
Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy Open
View article: Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data
Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data Open
Objective The COVID-19 pandemic was associated with a reduction in the incidence of myocardial infarction (MI) diagnosis, in part because patients were less likely to present to hospital. Whether changes in clinical decision making with re…
View article: Decision: Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm — R1/PR6
Decision: Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm — R1/PR6 Open
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To e…
View article: Recommendation: Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm — R1/PR5
Recommendation: Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm — R1/PR5 Open
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To e…
View article: Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
View article: Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial Open
Medical Research Council and National Institute of Health Research.
View article: Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm
Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm Open
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To e…
View article: Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection
Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection Open
Background & Aims The dynamics of HBV viral load (VL) in patients with chronic hepatitis B (CHB) on nucleos/tide analogue (NA) treatment and its relationship with liver disease are poorly understood. We aimed to study longitudinal VL patte…
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used fo…
View article: An International Perspective on The Protection of Freedom of Expression, with Special Emphasis on the Promotion of Racism, Xenophobia, and Religious Bigotry
An International Perspective on The Protection of Freedom of Expression, with Special Emphasis on the Promotion of Racism, Xenophobia, and Religious Bigotry Open
The right to freedom of expression is a pillar of any democratic and pluralistic society. However, according to current international human rights standards, this right should be limited for several reasons, including others' rights and ad…
View article: Identifying Hepatocellular Carcinoma from imaging reports using natural language processing to facilitate data extraction from electronic patient records
Identifying Hepatocellular Carcinoma from imaging reports using natural language processing to facilitate data extraction from electronic patient records Open
Background The National Institute for Health Research Health Informatics Collaborative (NIHR HIC) viral hepatitis theme is working to overcome governance and data challenges to collate routine clinical data from electronic patients records…
View article: Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset
Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset Open
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background: To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used f…
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background and aims To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarker…
View article: Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset
Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset Open
Purpose The National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) was established to enable re-use of routinely collected clinical data across National Health Service (NHS) Trusts in the United Kingdom to sup…
View article: Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study
Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study Open
View article: Longitudinal Analysis of the Utility of Liver Biochemistry as Prognostic Markers in Hospitalized Patients With Corona Virus Disease 2019
Longitudinal Analysis of the Utility of Liver Biochemistry as Prognostic Markers in Hospitalized Patients With Corona Virus Disease 2019 Open
The association of liver biochemistry with clinical outcomes of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is currently unclear, and the utility of longitudinally measured liver biochemistry as prognostic marker…
View article: Efficacy and safety of tenofovir disoproxil fumarate (TDF) in hepatitis B virus (HBV) monoinfection: longitudinal analysis of a UK cohort
Efficacy and safety of tenofovir disoproxil fumarate (TDF) in hepatitis B virus (HBV) monoinfection: longitudinal analysis of a UK cohort Open
Aim Current clinical recommendations suggest treating chronic hepatitis B virus (HBV) infection in a minority of cases, but more data are needed to determine the benefits and risks of Tenofovir disoproxil fumarate (TDF) therapy. We aimed t…
View article: National Institute for Health Research Health Informatics Collaborative: development of a pipeline to collate electronic clinical data for viral hepatitis research
National Institute for Health Research Health Informatics Collaborative: development of a pipeline to collate electronic clinical data for viral hepatitis research Open
Objective The National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) is a programme of infrastructure development across NIHR Biomedical Research Centres. The aim of the NIHR HIC is to improve the quality and …
View article: Longitudinal analysis of the utility of liver biochemistry in hospitalised COVID-19 patients as prognostic markers
Longitudinal analysis of the utility of liver biochemistry in hospitalised COVID-19 patients as prognostic markers Open
Background COVID-19, the clinical syndrome caused by infection with SARS-CoV-2, has been associated with deranged liver biochemistry in studies from China, Italy and the USA. However, the clinical utility of liver biochemistry as a prognos…
View article: National Institute for Health Research Health Informatics Collaborative (NIHR HIC): Development of a Pipeline to Collate Electronic Clinical Data for Viral Hepatitis Research
National Institute for Health Research Health Informatics Collaborative (NIHR HIC): Development of a Pipeline to Collate Electronic Clinical Data for Viral Hepatitis Research Open
Objective The National Institute of Health Research (NIHR) Health Informatics Collaborative (HIC) is a programme of infrastructure development across NIHR Biomedical Research Centres (BRCs). The aim of the NIHR HIC is to improve the qualit…
View article: Electronic Health Informatics Data To Describe Clearance Dynamics of Hepatitis B Surface Antigen (HBsAg) and e Antigen (HBeAg) in Chronic Hepatitis B Virus Infection
Electronic Health Informatics Data To Describe Clearance Dynamics of Hepatitis B Surface Antigen (HBsAg) and e Antigen (HBeAg) in Chronic Hepatitis B Virus Infection Open
Advances in the diagnosis, monitoring, and treatment of hepatitis B virus (HBV) infection are urgently required if we are to meet international targets for elimination by the year 2030. Here we demonstrate how routine clinical data can be …