Mahaboobkhan Rasool
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View article: Habbe Gule Aakh prevents glycolytic program and alleviates disease progression in a rheumatoid arthritis animal model
Habbe Gule Aakh prevents glycolytic program and alleviates disease progression in a rheumatoid arthritis animal model Open
Background The acquired tumorigenic phenotype of the resident fibroblast like synoviocytes (FLS) is cornerstone to exacerbating rheumatoid arthritis (RA) disease progression. Toll like receptor 4 (TLR4) signalling can sustain the prolifera…
View article: Antileishmanial Evaluation and Phytochemical Screening of Iraqi Sanchezia speciosa Petroleum Ether Fraction in vitro
Antileishmanial Evaluation and Phytochemical Screening of Iraqi Sanchezia speciosa Petroleum Ether Fraction in vitro Open
Leishmaniasis is a significant parasite issue. Vaccine inaccessibility and the absence of a safe and effective therapy that is not resistant to the illness hinders the total eradication of this disease and remains a challenge for the contr…
View article: Characteristics of rheumatoid arthritis patients in the Kurdistan Region of Iraq/Duhok Governorate
Characteristics of rheumatoid arthritis patients in the Kurdistan Region of Iraq/Duhok Governorate Open
View article: Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model
Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model Open
View article: CYT387 restores Th17/Treg cell balance and inhibits mature osteoclast cell formation by regulating SOX-5 signaling in rheumatoid arthritis
CYT387 restores Th17/Treg cell balance and inhibits mature osteoclast cell formation by regulating SOX-5 signaling in rheumatoid arthritis Open
The present study was conducted to investigate the therapeutic efficacy of CYT387 in rheumatoid arthritis pathogenesis concerning T helper 17 cell/regulatory T cell (Th17/Treg) imbalance and osteoclastogenesis. In this study, CYT 387 inhib…
View article: Abstract 24 — Myricetin Impedes Tfh Cell Differentiation and Ameliorates the Tumorigenic Phenotype of Adjuvant-Induced Arthritis FLS in Rheumatoid Arthritis
Abstract 24 — Myricetin Impedes Tfh Cell Differentiation and Ameliorates the Tumorigenic Phenotype of Adjuvant-Induced Arthritis FLS in Rheumatoid Arthritis Open
Background Rheumatoid arthritis (RA) is an autoimmune disorder characterized by destructive polyarthritis and extra-articular manifestations. Myricetin, a flavonoid, possesses several pharmacological benefits, including anti-arthritic effe…
View article: Majoon Chobchini attenuates arthritis disease severity and RANKL-mediated osteoclastogenesis in rheumatoid arthritis
Majoon Chobchini attenuates arthritis disease severity and RANKL-mediated osteoclastogenesis in rheumatoid arthritis Open
View article: PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor
PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor Open
View article: Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug
Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug Open
Background Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had pot…
View article: InCl3 mediated heteroarylation of indoles and their derivatization via C H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis
InCl3 mediated heteroarylation of indoles and their derivatization via C H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis Open
View article: Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-κB pathway
Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-κB pathway Open
This study sought to explore the mechanism of anti-inflammatory effect of triphala in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in adjuvant-induced arthritic rats. In stimulated RAW 264.7 cells, triphala (100-300 μg/ml)…
View article: Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation
Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation Open
Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-inflammatory effect against adjuvant-induced arthritic rats. In this current study, we investigated the anti-inflammatory mechanism of morin against monosod…
View article: Biochemical Evaluation of Withania somnifera Root Powder on Adjuvant-Induced Arthritis in Rats
Biochemical Evaluation of Withania somnifera Root Powder on Adjuvant-Induced Arthritis in Rats Open
The present investigation was carried out to evaluate the biochemical effect of Withania somnifera Linn. Solanaceae, commonly known as ashwagandha on adjuvant induced arthritic rats. Results were compared to Indomethacin, a non steroidal a…
View article: Attenuation of the toxic effects of bromobenzene on the kidneys in Wistar albino rats by the blue green algae Spirulina fusiformis
Attenuation of the toxic effects of bromobenzene on the kidneys in Wistar albino rats by the blue green algae Spirulina fusiformis Open
School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India E-mail : [email protected] The present study was aimed to assess the nephroprotective role of Spirulina fusiformis on bromobenzene (BB) induced to…
View article: Mitigation of biochemical and histological effects of bromobenzene on the hepatic system in rats by the Indian herbal drug formulation Triphala
Mitigation of biochemical and histological effects of bromobenzene on the hepatic system in rats by the Indian herbal drug formulation Triphala Open
School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India E-mail : [email protected] The present study is an attempt to evaluate the hepatoprotective and anti-oxidant properties of Triphala against bro…