Mohammed S. Al‐Dosari
YOU?
Author Swipe
View article: Knowledge and attitude of parents toward human papillomavirus infection and HPV vaccination in Riyadh, Saudi Arabia
Knowledge and attitude of parents toward human papillomavirus infection and HPV vaccination in Riyadh, Saudi Arabia Open
A BSTRACT Background: This study examined the knowledge and attitudes of parents in Riyadh, Saudi Arabia, regarding human papillomavirus (HPV) and its vaccine. Recognizing the critical role of parental awareness in vaccine acceptance, the …
View article: Risk factors and diagnostic approaches to lower extremity stress fractures in athletes: Systematic review
Risk factors and diagnostic approaches to lower extremity stress fractures in athletes: Systematic review Open
Background: Stress fractures (SF) are frequent overuse injuries, with the lower extremities accounting for up to 95% of cases. Lower extremities SFs (LESFs) are common injuries among athletes who play endurance sports with high loads. Obje…
View article: Inhibitory Activity of Chalcones as MAO‐B Inhibitors: An Insight from Molecular Docking, ADME Analysis, MD Simulation, and MM‐PBSA Calculations
Inhibitory Activity of Chalcones as MAO‐B Inhibitors: An Insight from Molecular Docking, ADME Analysis, MD Simulation, and MM‐PBSA Calculations Open
Alzheimer's disease, which is recognized as a progressive, multifaceted neurodegenerative disorder, is the main factor in late‐life dementia. Monoamine oxidase‐B (MAO‐B) has recently been identified as a potential therapeutic target for Al…
View article: Assessing the Impact of Irritable Bowel Syndrome on Quality of Life in Patients at Family Medicine and Primary Health Care Clinics of the National Guard Health Affairs, Riyadh
Assessing the Impact of Irritable Bowel Syndrome on Quality of Life in Patients at Family Medicine and Primary Health Care Clinics of the National Guard Health Affairs, Riyadh Open
View article: Assessment of appropriate utilization of out-of-office diagnostic tools for the diagnosis of hypertension
Assessment of appropriate utilization of out-of-office diagnostic tools for the diagnosis of hypertension Open
A BSTRACT Background: Out-of-office blood pressure (BP) measurement devices, such as ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM), enhance the accuracy and reliability of BP readings, detecting white-coat and masked hypert…
View article: In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40
In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40 Open
VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in the viral lifecycle. Targeting these proteins could disrupt key stages of the vira…
View article: Role of APOC3 3238C/G, APOB 12669G/A and SCARB1 1050C/T polymorphisms, their expression in patients of HIV-associated lipodystrophy
Role of APOC3 3238C/G, APOB 12669G/A and SCARB1 1050C/T polymorphisms, their expression in patients of HIV-associated lipodystrophy Open
Apolipoproteins and Scavenger Receptor Class B1 (SCARB1) proteins are involved in the etiology of HIV-associated lipodystrophy (HIVLD). APOC3 3238C/G, APOB 12669G/A and SCARB1 1050C/T polymorphisms were linked with inc…
View article: A Survey of Deep Learning and Foundation Models for Time Series Forecasting
A Survey of Deep Learning and Foundation Models for Time Series Forecasting Open
Deep Learning has been successfully applied to many application domains, yet its advantages have been slow to emerge for time series forecasting. For example, in the well-known Makridakis (M) Competitions, hybrids of traditional statistica…
View article: Development and validation of an Arabic language eye‐tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar
Development and validation of an Arabic language eye‐tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar Open
Abnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD). The primary aim of the present research was to develop an Arabic version of an objective measure of ASD, the “autism index” (AI), based on eye gaze tracking …
View article: Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication
Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication Open
Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA…
View article: Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors Open
Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegy…
View article: <i>In Silico</i> Identification of Deep-Sea Fungal Alkaloids as Potential Inhibitors of SARS-CoV-2, Delta and Omicron Spikes
<i>In Silico</i> Identification of Deep-Sea Fungal Alkaloids as Potential Inhibitors of SARS-CoV-2, Delta and Omicron Spikes Open
Aim: Virtual screening of deep-sea fungal metabolites against SARS-CoV-2 Delta and Omicron spikes as potential antivirals. Materials & methods: Deep-sea fungal alkaloids (n ≥ 150) were evaluated against SARS-CoV-2, Delta and …
View article: Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel Open
Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degrad…
View article: Deep-sea fungal metabolites as potential inhibitors of glucose-regulatory enzymes: In silico structure–activity analysis
Deep-sea fungal metabolites as potential inhibitors of glucose-regulatory enzymes: In silico structure–activity analysis Open
View article: Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells
Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells Open
Diabetes, characterized by high blood glucose level, is a progressive metabolic disease that leads to serious health complications. One of the major pathological consequences associated with diabetes is the accumulation of highly reactive …
View article: Inhibition of hepatitis B virus activities by <i>Rhazya stricta</i>‑derived acacetin and acetyl‑β‑carboline
Inhibition of hepatitis B virus activities by <i>Rhazya stricta</i>‑derived acacetin and acetyl‑β‑carboline Open
Hepatitis B virus (HBV) causes acute and chronic liver diseases, leading to cirrhosis and hepatocellular carcinoma. Although direct-acting nucleoside analogs, such as lamivudine (LAM), adefovir and famciclovir, are available, emergence of …
View article: Structure-Based Virtual Identification of Natural Inhibitors of SARS-CoV-2 and its Delta and Omicron Variant Proteins
Structure-Based Virtual Identification of Natural Inhibitors of SARS-CoV-2 and its Delta and Omicron Variant Proteins Open
Quercetin-3-acetyl-glucoside, Rutin, Kaempferol, Catechin, Orientin, Obetrioside and Neridienone A were identified as potential inhibitors of SARS-CoV-2 Mpro, Helicase and Spike, while Orientin and Obetrioside also showed good binding affi…
View article: Categorical versus dimensional structure of autism spectrum disorder: A multi‐method investigation
Categorical versus dimensional structure of autism spectrum disorder: A multi‐method investigation Open
Background A key question for any psychopathological diagnosis is whether the condition is continuous or discontinuous with typical variation. The primary objective of this study was to use a multi‐method approach to examine the broad late…
View article: Public Knowledge About Hijamah, Attitudes, Beliefs and Impact on Health-Related Quality of Life in Riyadh, Saudi Arabia
Public Knowledge About Hijamah, Attitudes, Beliefs and Impact on Health-Related Quality of Life in Riyadh, Saudi Arabia Open
Background and Aims: Wet cupping, which is known as Hijamah, is one of the most commonly practiced therapeu¬tic procedures in Saudi Arabia. Hijamah centers have been really popularized, reaching up to 119 licensed centers in the country. D…
View article: Sterols from <i>Centaurea pumilio</i> L. with cell proliferative activity: <i>In vitro</i> and <i>in silico</i> studies
Sterols from <i>Centaurea pumilio</i> L. with cell proliferative activity: <i>In vitro</i> and <i>in silico</i> studies Open
Numerous studies highlighted the impact of natural products, particularly phytosterols, in wound healing while providing less expensive alternatives to chemically synthesized drugs, with less side effects. Centaurea pumilio L. (family Aste…
View article: On Transformer Autoregressive Decoding for Multivariate Time Series Forecasting
On Transformer Autoregressive Decoding for Multivariate Time Series Forecasting Open
The success of the Transformer model has promoted recent advances in time series forecasting.This adoption sparked an interest in developing efficient Transformer models that scale well for forecasting long sequences.This involves maintain…
View article: The anti‑hepatitis B virus activity of sea buckthorn is attributed to quercetin, kaempferol and isorhamnetin
The anti‑hepatitis B virus activity of sea buckthorn is attributed to quercetin, kaempferol and isorhamnetin Open
The present study assessed the in vitro anti-hepatitis B virus (HBV) effects of cold-adapted sea buckthorn (Hippophae rhamnoides). Sea buckthorn leaf ethanol extracts subjected to chloroform (SB-Chl), ethyl acetate (SB-Eac), …
View article: Novel anti‑hepatitis B virus‑active catechin and epicatechin from<i>Rhus tripartita</i>
Novel anti‑hepatitis B virus‑active catechin and epicatechin from<i>Rhus tripartita</i> Open
Bioactive natural or phytoproducts have emerged as a potential source of antiviral agents. Of the Rhus spp., R. coriaria and R. succedanea have been reported for their antiviral activities against hepatitis B virus (HB…
View article: The anti-hepatitis B virus and anti-hepatotoxic efficacies of solanopubamine, a rare alkaloid from Solanum schimperianum
The anti-hepatitis B virus and anti-hepatotoxic efficacies of solanopubamine, a rare alkaloid from Solanum schimperianum Open
Chronic liver disease caused by hepatitis B virus (HBV) remains an important health issue. Though there are effective HBV-polymerase inhibitors (e.g., lamivudine), their prolonged use leads to emergence of drug-resistant (polymerase mutant…
View article: Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree)
Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree) Open
Hepatitis B virus (HBV) infection is prevalent and continues to be a global health concern. In this study, we determined the anti-hepatitis B virus (HBV) potential of the Socotra-endemic medicinal plant Dracaena cinnabari and isolated and …
View article: The anti-oxidative, anti-cell proliferative and anti-microbial efficacies of cold-adapted Crepis flexuosa: HPTLC and GC/MS analyses
The anti-oxidative, anti-cell proliferative and anti-microbial efficacies of cold-adapted Crepis flexuosa: HPTLC and GC/MS analyses Open
The genus Crepis constitutes cold-adapted plant spp., of these some are traditionally used in folk medicine against inflammation or fungal infections without scientific validations. Here, we report the biological activities of Cr…
View article: Machine learning-based predictive models for identifying high active compounds against HIV-1 integrase
Machine learning-based predictive models for identifying high active compounds against HIV-1 integrase Open
HIV-integrase is an important drug target because it catalyzes chromosomal integration of proviral DNA towards establishing latent infection. Computer-aided drug design has immensely contributed to identifying and developing novel antivira…
View article: Corrigendum to “New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells”. [Saudi Pharm. J. 29(10) (2021) 1102–1111]
Corrigendum to “New terpenic and phenolic compounds from Suaeda monoica reverse oxidative and apoptotic damages in human endothelial cells”. [Saudi Pharm. J. 29(10) (2021) 1102–1111] Open
View article: Novel Anti-Hepatitis B Virus Activity of <i>Euphorbia schimperi</i> and Its Quercetin and Kaempferol Derivatives
Novel Anti-Hepatitis B Virus Activity of <i>Euphorbia schimperi</i> and Its Quercetin and Kaempferol Derivatives Open
Natural or plant products, because of their structural diversity, are a potential source for identifying new anti-hepatitis B virus (HBV) agents. Here, we report the anti-HBV activity of Euphorbia schimperi and its quercetin (QRC) a…
View article: In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum
In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum Open
This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties o…