Mohan L. Sopori
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View article: Inflammation-Associated Lung Tissue Remodeling and Fibrosis in Morphine-Dependent SIV-Infected Macaques
Inflammation-Associated Lung Tissue Remodeling and Fibrosis in Morphine-Dependent SIV-Infected Macaques Open
View article: Corrigendum: Increased expression of LASI LncRNA regulates the cigarette smoke and COPD associated airway inflammation and mucous cell hyperplasia
Corrigendum: Increased expression of LASI LncRNA regulates the cigarette smoke and COPD associated airway inflammation and mucous cell hyperplasia Open
[This corrects the article DOI: 10.3389/fimmu.2022.803362.].
View article: Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia
Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia Open
Research Impact Cigarette smoke (CS) exposure is strongly associated with chronic obstructive pulmonary disease (COPD). In respiratory airways, CS exposure disrupts airway barrier functions, mucous/phlegm production, and basic immune respo…
View article: The Novel Long Noncoding RNA Transcript LASI Is Associated with Smoke-Induced Inflammation and Airway Pathology of COPD Patients
The Novel Long Noncoding RNA Transcript LASI Is Associated with Smoke-Induced Inflammation and Airway Pathology of COPD Patients Open
View article: HIV-1 Productively Infects and Integrates in Bronchial Epithelial Cells
HIV-1 Productively Infects and Integrates in Bronchial Epithelial Cells Open
Background The role of lung epithelial cells in HIV-1-related lung comorbidities remains unclear, and the major hurdle in curing HIV is the persistence of latent HIV reservoirs in people living with HIV (PLWH). The advent of combined antir…
View article: Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally
Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally Open
Rationale: Gestational cigarette smoke (CS) impairs lung angiogenesis and alveolarization, promoting transgenerational development of asthma and bronchopulmonary dysplasia (BPD). Hydrogen sulfide (H2S), a proangiogenic, p…
View article: Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration
Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration Open
In the era of highly active anti-retroviral therapy (HAART), obstructive lung diseases (OLDs) are common among the people living with HIV (PLWH); however, the mechanism by which HIV induces OLDs is unclear. Although human bronchial epithel…
View article: The Role of MTFP1 in Regulating Airway Epithelial Mitochondrial Dynamics and Inflammatory Responses Following Cigarette Smoke Exposure and in COPD
The Role of MTFP1 in Regulating Airway Epithelial Mitochondrial Dynamics and Inflammatory Responses Following Cigarette Smoke Exposure and in COPD Open
View article: Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis
Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis Open
View article: Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques
Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques Open
In the era of combined antiretroviral therapy (cART), lung diseases such as chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) are common among persons living with HIV (PLWH), particularly smokers. Although smoking is…
View article: A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells
A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells Open
View article: Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia
Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia Open
Embryonic development is highly sensitive to xenobiotic toxicity and in utero exposure to environmental toxins affects physiological responses of the progeny. In the United States, the prevalence of allergic asthma (AA) is inexplicably ris…
View article: HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice
HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice Open
Gestational SS-induced BPD is potentially regulated by nAChRs and associated with downregulation of HIF-1α, increased apoptosis of epithelial cells, and increased alveolar volumes. Thus, in mice, exposure to sidestream tobacco smoke during…
View article: Renal systems biology of patients with systemic inflammatory response syndrome
Renal systems biology of patients with systemic inflammatory response syndrome Open
View article: Renal systems biology of patients with systemic inflammatory response syndrome
Renal systems biology of patients with systemic inflammatory response syndrome Open
A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this we examined the metabolome, proteome, and transcriptome of 150 pa…