Mohd Omar Faruk Sikder
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View article: α-Methyl-<scp>l</scp>-tryptophan as a weight-loss agent in multiple models of obesity in mice
α-Methyl-<span>l</span>-tryptophan as a weight-loss agent in multiple models of obesity in mice Open
α-Methyl-L-tryptophan (α-MLT) is currently in use as a tracer in its 11C-labeled form to monitor the health of serotonergic neurons in humans. In the present study, we found this compound to function as an effective weight-loss agent at ph…
View article: SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet
SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet Open
View article: SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling
SLC6A14, a Na+/Cl−-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling Open
SLC6A14 is a Na+/Cl−-coupled transporter for neutral and cationic amino acids. It is expressed at basal levels in the normal colon but is up-regulated in colon cancer. However, the relevance of this up-regulation to cancer progression and …
View article: The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment Open
GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether lactate has any paracrine role via activation…
View article: Deficiency of Dietary Fiber in <i>Slc5a8</i>-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu
Deficiency of Dietary Fiber in <i>Slc5a8</i>-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu Open
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota. Various factors alter the gut microbiota which…
View article: Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis
Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis Open
View article: Characterization, prevalence and antibiogram study of Staphylococcus aureus in poultry
Characterization, prevalence and antibiogram study of Staphylococcus aureus in poultry Open
Objective: To reveal the presence of methicillin resistant Staphylococcus aureus (S. aureus) (MRSA) in poultry samples and to determine the antibiogram pattern against five antibiotics. Methods: Samples from different poultry farm of Chitt…
View article: In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design
In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design Open
The study was carried out to predict antigenic determinants/epitopes of the E3 CR1-beta protein of Human Adenovirus E along with the 3D protein modeling. The study revealed potential T-cell and B-cell epitopes that can raise the desired im…
View article: Mining the Proteome of<i>Fusobacterium nucleatum</i>subsp.<i>nucleatum</i>ATCC 25586 for Potential Therapeutics Discovery: An<i>In Silico</i>Approach
Mining the Proteome of<i>Fusobacterium nucleatum</i>subsp.<i>nucleatum</i>ATCC 25586 for Potential Therapeutics Discovery: An<i>In Silico</i>Approach Open
The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge of the increasing resistance of pathogen…