Sadia Mohsin
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View article: Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway
Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway Open
Hyperlipidemia and chronic kidney disease (CKD) are well-established risk factors for cardiovascular disease and act synergistically to promote vascular inflammation and disease progression. However, the mechanisms underlying this synerget…
View article: Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression
Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression Open
Review Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression Ying Shao 1,2,†, William Y. Yang 1,†, Gayani Nanayakkara 3,†, Fatma Saaoud 1,†, M…
View article: SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome
SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome Open
In this study, we observed worsening metabolic crosstalk in mouse models with concomitant metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and hyperglycemia and in human coronary artery disease by analyzing metaboli…
View article: WITHDRAWN: SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome
WITHDRAWN: SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome Open
In this study, we observed worsening metabolic crosstalk in mouse models with concomitant metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and hyperglycemia and in human coronary artery disease by analyzing metaboli…
View article: Inflammation attenuating lncRNAs in diabetic cardiomyopathy
Inflammation attenuating lncRNAs in diabetic cardiomyopathy Open
Diabetic cardiomyopathy refers to cardiac structural and functional impairments associated with hyperglycemia and obesity in patients with cardiovascular disease. Clinical outcomes are significantly worst for cardiovascular patients with d…
View article: Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair
Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair Open
The adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are unable to divide and form new myocytes in response to myocardial injury. In contrast, the developmental cardiac tissue is made up of proliferative CMs t…
View article: Systemic Hypoxemia Induces Cardiomyocyte Hypertrophy and Right Ventricular Specific Induction of Proliferation
Systemic Hypoxemia Induces Cardiomyocyte Hypertrophy and Right Ventricular Specific Induction of Proliferation Open
Background: A recent study suggests that systemic hypoxemia in adult male mice can induce cardiac myocytes to proliferate. The goal of the present experiments was to confirm these results, provide new insights on the mechanisms that induce…
View article: RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19
RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19 Open
Background: Developmental cardiac tissue holds remarkable capacity to regenerate after injury and consists of regenerative mononuclear diploid cardiomyocytes. On maturation, mononuclear diploid cardiomyocytes become binucleated or polyploi…
View article: Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model
Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model Open
Combination of 3D collagen scaffold and zebularine treatment enhances cardiac differentiation potential of MSCs, improves cell engraftment at the infarcted region, reduces infarct size and improves cardiac function.
View article: UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia
UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia Open
Developmental cardiac tissue is regenerative while operating under low oxygen. After birth, ambient oxygen is associated with cardiomyocyte cell cycle exit and regeneration. Likewise, cardiac metabolism undergoes a shift with cardiac matur…
View article: Quality of Life of Melasma Patients in Pakistan
Quality of Life of Melasma Patients in Pakistan Open
Objective: To assess the quality of life in Pakistani melasma patients.
Study Design: Cross-sectional study.
Place and Duration of Study: Department of Dermatology, Combined Military Hospital Lahore, from Oct 2020 to May 2021.
Methodolo…
View article: Cell Surface and Functional Features of Cortical Bone Stem Cells
Cell Surface and Functional Features of Cortical Bone Stem Cells Open
The newly established mouse cortical-bone-derived stem cells (mCBSCs) are unique stem cells compared to mouse mesenchymal stem cells (mMSCs). The mCBSC-treated hearts after myocardial infarction have been reported to have greater improveme…
View article: Cortical bone stem cell-derived exosomes’ therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling
Cortical bone stem cell-derived exosomes’ therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling Open
Our work is noteworthy due to the identification of factors within stem cell-derived exosomes (dEXOs) that alter fibroblast activation through the hereto-unknown mechanism of decreasing small nucleolar RNA (snoRNA) signaling within cardiac…
View article: Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype Open
Cortical bone stem cell (CBSC) therapy after myocardial infarction alters the inflammatory response to cardiac injury. We found that cortical bone stem cell therapy induces a unique macrophage phenotype in vitro and can modulate macrophage…
View article: Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation
Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation Open
Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and mortality worldwide. Multiple stem cell types have been safely transferred into failing human hearts, but the overall clinical cardiovascular ben…
View article: Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart
Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart Open
Cardiac diseases such as myocardial infarction (MI) can lead to adverse remodeling and impaired contractility of the heart due to widespread cardiomyocyte death in the damaged area. Current therapies focus on improving heart contractility …
View article: Transcriptional Profiling of Cardiac Cells Links Age-Dependent Changes in Acetyl-CoA Signaling to Chromatin Modifications
Transcriptional Profiling of Cardiac Cells Links Age-Dependent Changes in Acetyl-CoA Signaling to Chromatin Modifications Open
Metabolism has emerged as a regulator of core stem cell properties such as proliferation, survival, self-renewal, and multilineage potential. Metabolites serve as secondary messengers, fine-tuning signaling pathways in response to microenv…
View article: Cardiac Remodeling During Pregnancy With Metabolic Syndrome
Cardiac Remodeling During Pregnancy With Metabolic Syndrome Open
Background: The heart undergoes physiological hypertrophy during pregnancy in healthy individuals. Metabolic syndrome (MetS) is now prevalent in women of child-bearing age and might add risks of adverse cardiovascular events during pregnan…
View article: Stem Cell Metabolism: Powering Cell-Based Therapeutics
Stem Cell Metabolism: Powering Cell-Based Therapeutics Open
Cell-based therapeutics for cardiac repair have been extensively used during the last decade. Preclinical studies have demonstrated the effectiveness of adoptively transferred stem cells for enhancement of cardiac function. Nevertheless, s…
View article: Role of Stem Cell–Derived Microvesicles in Cardiovascular Disease
Role of Stem Cell–Derived Microvesicles in Cardiovascular Disease Open
The role of stem cells in augmenting reparative processes in the heart after ischemic injury has been successfully demonstrated in small and large animal models. However, the outcomes of cell therapy in clinical trials have been somewhat v…
View article: Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age
Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age Open
Cellular replacement in the heart is restricted to postnatal stages with the adult heart largely postmitotic. Studies show that loss of regenerative properties in cardiac cells seems to coincide with alterations in metabolism during postna…
View article: The Regulatory Role of T Cell Responses in Cardiac Remodeling Following Myocardial Infarction
The Regulatory Role of T Cell Responses in Cardiac Remodeling Following Myocardial Infarction Open
Ischemic injury to the heart causes cardiomyocyte and supportive tissue death that result in adverse remodeling and formation of scar tissue at the site of injury. The dying cardiac tissue secretes a variety of cytokines and chemokines tha…
View article: Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury
Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury Open
CBSCs reduce fibroblast to myofibroblast transition and differentiation in adult cardiac fibroblasts via miR-18a-5p. This finding reveals a new avenue for cell therapies to target myocardial scar modulation and provides a resolution for th…
View article: Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy
Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy Open
Cardiovascular Disease (CVD) is a leading cause of mortality within the United States. Current treatments being administered to patients who suffered a myocardial infarction (MI) have increased patient survival, but do not facilitate the r…
View article: <i>Abcg2</i> ‐expressing side population cells contribute to cardiomyocyte renewal through fusion
<i>Abcg2</i> ‐expressing side population cells contribute to cardiomyocyte renewal through fusion Open
The adult mammalian heart has a limited regenerative capacity. Therefore, identification of endogenous cells and mechanisms that contribute to cardiac regeneration is essential for the development of targeted therapies. The side population…