Marc Ansari
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View article: Comparison of outcomes in pediatric patients with acute leukemia undergoing allogeneic HLA-haploidentical hematopoietic stem cell transplantation (HSCT) after in vitro a/b T- and CD19-cell depletion or In Vivo administration of post-transplant cyclophosphamide: An EBMT pediatric working party study
Comparison of outcomes in pediatric patients with acute leukemia undergoing allogeneic HLA-haploidentical hematopoietic stem cell transplantation (HSCT) after in vitro a/b T- and CD19-cell depletion or In Vivo administration of post-transplant cyclophosphamide: An EBMT pediatric working party study Open
Background HLA-haploidentical relatives are increasingly used to transplant children with acute leukemia (AL) requiring an allograft. The 2 most widely employed platforms to overcome the bidirectional alloreactivity are in vitro a/b T- and…
View article: Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the <scp>EBMT</scp> Paediatric Diseases Working Party
Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the <span>EBMT</span> Paediatric Diseases Working Party Open
Summary Evolution of acute myeloid leukaemia (AML) treatments and transplantation procedures may affect outcomes after second haematopoietic stem cell transplantation (HSCT2) for relapsed paediatric AML. We analysed 345 paediatric patients…
View article: Molecular Profiling of SYT-SSX Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas
Molecular Profiling of SYT-SSX Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas Open
Background/Objectives: Synovial sarcoma (SS) is an aggressive soft-tissue tumor characterized by the chromosomal translocation t(X;18) (p11.2;q11.2), most commonly involving the fusion of the SYT gene on chromosome 18 with the SSX1 or SSX2…
View article: Pulmonary function in young childhood cancer survivors: results from a prospective multicentre cohort
Pulmonary function in young childhood cancer survivors: results from a prospective multicentre cohort Open
Background Childhood cancer survivors (CCS) are at risk of pulmonary late effects, but post-treatment lung function remains understudied. Current guidelines recommend screening only for symptomatic survivors treated with lung-damaging trea…
View article: Harmonized immune recovery monitoring after HCT: evidence and practical guidance from the Westhafen Intercontinental Group
Harmonized immune recovery monitoring after HCT: evidence and practical guidance from the Westhafen Intercontinental Group Open
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative option for patients with high-risk malignancies and nonmalignant disorders. Long-term survival depends on robust immune reconstitution (IR), which governs overall immun…
View article: Genetic polymorphisms contributing to hearing loss in children treated with platinum agents: a systematic review and meta-analysis protocol
Genetic polymorphisms contributing to hearing loss in children treated with platinum agents: a systematic review and meta-analysis protocol Open
Introduction The improved survival rates of children with cancer have heightened concerns about treatment-related chronic health conditions, including platinum-induced hearing loss (PIHL). Cisplatin and carboplatin, widely used in paediatr…
View article: Evaluation of a new, community-based screening program to detect hearing loss in adult childhood cancer survivors in Switzerland – Findings from the HEAR study
Evaluation of a new, community-based screening program to detect hearing loss in adult childhood cancer survivors in Switzerland – Findings from the HEAR study Open
2. Abstract Purpose Childhood cancer survivors have an increased risk of long-term health complications, including treatment-related hearing loss. Although early detection is important, many adult survivors do not attend hearing screenings…
View article: Molecular and Pharmacogenetic marker evaluation in relation to the toxicity and clinical response of acute lymphoblastic leukemia treatment in Indian children (MPGx-INDALL): A Prospective observational cohort study protocol (Preprint)
Molecular and Pharmacogenetic marker evaluation in relation to the toxicity and clinical response of acute lymphoblastic leukemia treatment in Indian children (MPGx-INDALL): A Prospective observational cohort study protocol (Preprint) Open
BACKGROUND Understanding inter-individual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymphoblastic leukemia (ALL). Molecular and pharmacogenetic markers hold promise in predictin…
View article: Exercise-induced symptoms in young childhood cancer survivors
Exercise-induced symptoms in young childhood cancer survivors Open
Purpose Exercise-induced symptoms (EIS) are common in children and understudied in childhood cancer survivors (CCS). We assessed the prevalence of EIS in CCS and identified associated risk factors. Methods We included CCS aged 6–21 years w…
View article: Roles of HLA-DRB107 :01 and HLA-B15 :01 in the risk of acute Graft Versus Host Disease in pediatric patients undergoing HSCT
Roles of HLA-DRB107 :01 and HLA-B15 :01 in the risk of acute Graft Versus Host Disease in pediatric patients undergoing HSCT Open
Graft Versus Host Disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Previous studies suggest that genes coding for different components of the immune system, like human leukocyte antigen …
View article: Exercise-induced symptoms in young childhood cancer survivors
Exercise-induced symptoms in young childhood cancer survivors Open
Purpose Exercise-induced symptoms (EIS) are common in children and understudied in childhood cancer survivors (CCS). We assessed the prevalence of EIS in CCS and identified associated risk factors. Methods We included children aged 6-20 ye…
View article: Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia
Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia Open
CBFA2T3::GLIS2 fusion positive pediatric acute myeloid leukemia (AML) remains one of the worst prognostic AML subgroups. To uncover innovative targeted therapeutic approaches in this disease subtype we performed genome-scale CRISPR-Cas9 sc…
View article: Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure
Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure Open
Malignant liver tumors affecting children and adolescents are rare. In order to adequately study liver tumors occurring in this patient population and establish a more uniform approach to therapy, the three primary liver tumor consortia, S…
View article: Meeting the Challenges of Post‐Transplant Lymphoproliferative Disorders After Liver Transplantation in Children: A Proposed Diagnostic and Management Algorithm
Meeting the Challenges of Post‐Transplant Lymphoproliferative Disorders After Liver Transplantation in Children: A Proposed Diagnostic and Management Algorithm Open
Background Post‐transplant lymphoproliferative disorders (PTLD) may significantly impair outcomes in children after solid organ transplantation (SOT). Diagnosis and treatment may be challenging. We analyze a representative pediatric liver …
View article: A Health Service Research Study on a Low-Threshold Hearing Screening Program for Childhood Cancer Survivors in Switzerland: Protocol for the HEAR Study
A Health Service Research Study on a Low-Threshold Hearing Screening Program for Childhood Cancer Survivors in Switzerland: Protocol for the HEAR Study Open
Background Hearing loss is a common late effect in childhood cancer survivors, caused by ototoxic cancer treatments, such as platinum chemotherapy, cranial radiation with doses of ≥30 Gray, and surgery involving the auditory system. Early …
View article: Global Trends and Insights Into the Neurological Manifestations of Sjögren's Syndrome: A Bibliometric Review
Global Trends and Insights Into the Neurological Manifestations of Sjögren's Syndrome: A Bibliometric Review Open
Neurological symptoms in Sjögren's syndrome (SS) present across a spectrum of severity, posing diagnostic and therapeutic challenges. This bibliometric review adopts a comprehensive approach to analyze the research landscape related to the…
View article: Awareness about the risk of hearing loss after ototoxic treatments in Swiss childhood cancer survivors
Awareness about the risk of hearing loss after ototoxic treatments in Swiss childhood cancer survivors Open
Educating CCS about potential late effects of ototoxic treatments is important to allow early diagnosis and treatment, especially for those who had cancer longer ago and those exposed to cranial radiation.
View article: Financial Support and Income Satisfaction Among Grandparents of Childhood Cancer Patients: A Brief Report
Financial Support and Income Satisfaction Among Grandparents of Childhood Cancer Patients: A Brief Report Open
Childhood cancer imposes a financial burden on families. We explored the financial support grandparents provide to parents of childhood cancer patients and their income satisfaction over the two years post‐diagnosis. Twenty‐nine families s…
View article: Hearing screening beyond the clinic: Childhood cancer survivors’ perspectives on a novel hearing screening program
Hearing screening beyond the clinic: Childhood cancer survivors’ perspectives on a novel hearing screening program Open
Purpose Childhood cancer survivors (CCS) are at risk for late effects including hearing loss due to ototoxic treatments. It is crucial to detect late effects like hearing loss early, but many adult CCS do not attend recommended follow-up c…
View article: Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp–Pulmo)
Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp–Pulmo) Open
Background Childhood cancer survivors (CCS) are at risk of pulmonary dysfunction due to cancer treatments, but evidence on prevalence and risk factors remains limited. Most previous studies had small sample sizes or retrospective study des…
View article: Impact of Prosthodontic Treatment on Older Patients Pertaining to Their Self-Esteem and Functional Efficiency - A Questionnaire Based Study
Impact of Prosthodontic Treatment on Older Patients Pertaining to Their Self-Esteem and Functional Efficiency - A Questionnaire Based Study Open
The aging global population has led to a rise in edentulism, significantly affecting the oral health, self-esteem, and functional efficiency of older adults. Prosthodontic interventions, such as complete dentures and implant-supported pros…
View article: Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer
Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer Open
Background: Ototoxicity is a highly prevalent, serious, and irreversible side effect in cisplatin-treated childhood cancer patients, which can significantly impact speech-language development, psychosocial development, and quality of life.…
View article: Assessing pulmonary function in children and adolescents after cancer treatment: protocol for a multicenter cohort study (SCCSS FollowUp–Pulmo) (Preprint)
Assessing pulmonary function in children and adolescents after cancer treatment: protocol for a multicenter cohort study (SCCSS FollowUp–Pulmo) (Preprint) Open
BACKGROUND Childhood cancer survivors (CCS) are at risk of pulmonary dysfunction due to cancer treatments, but evidence on prevalence and risk factors remains limited. Most previous studies had small sample sizes or retrospective study de…
View article: Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11
Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11 Open
Background We previously demonstrated that APR-246 (eprenetapopt) could be an efficient treatment option against neuroblastoma (NB), the most common pediatric extracranial solid tumor. APR-246’s mechanism of action is not completely unders…
View article: Validation of the stratification for newly diagnosed hepatoblastoma: An analysis from the Children’s Hepatic tumors International Collaboration (CHIC) database
Validation of the stratification for newly diagnosed hepatoblastoma: An analysis from the Children’s Hepatic tumors International Collaboration (CHIC) database Open
Introduction: The Children’s Hepatic Tumors International Collaboration (CHIC) previously developed the CHIC hepatoblastoma risk stratification (CHIC-HS) model by analyzing the original CHIC dataset (development set). A validation of the r…
View article: In vitro screening of <scp>UGT2B10</scp> in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting
In vitro screening of <span>UGT2B10</span> in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting Open
UGT2B10 is a phase II drug metabolizing enzyme with limited information on its role in the metabolism of drugs, especially in the pediatric hematopoietic stem cell transplantation setting. Previously, we investigated UGT2B10's role through…
View article: Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM
Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM Open
The superiority of total body irradiation (TBI)–based vs chemotherapy conditioning for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukemia (ALL) has been established in the internati…
View article: Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset
Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset Open
Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient's skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T cells. The onset of aGVHD is often rapid and it…
View article: Long-Term Follow-Up of a Child with EWSR1-BEND2 Fused Spinal Astroblastoma
Long-Term Follow-Up of a Child with EWSR1-BEND2 Fused Spinal Astroblastoma Open
Introduction: Spinal astroblastoma is a rare highly malignant tumor that mainly affects children. We review the few cases described in the literature and highlight the challenges of managing this neoplasm by illustrating a case recently tr…
View article: Microcavity-assisted cloning (MAC) of hard-to-clone HepG2 cell lines: cloning made easy
Microcavity-assisted cloning (MAC) of hard-to-clone HepG2 cell lines: cloning made easy Open
Cloning is a key molecular biology procedure for obtaining a genetically homogenous population of organisms or cell lines. It requires the expansion of new cell populations starting from single genetically modified cells. Despite the techn…