Mohammad Saquib
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View article: Impact of Blood Volume on Pathogen Detection and Time to Positivity in Paediatric Blood Cultures Using BACT/ALERT 3D Automated Systems
Impact of Blood Volume on Pathogen Detection and Time to Positivity in Paediatric Blood Cultures Using BACT/ALERT 3D Automated Systems Open
Background Bloodstream infections (BSIs) are a major cause of morbidity and mortality in paediatric populations. Early and accurate pathogen detection is crucial for prompt therapy. Blood volume is a key factor influencing culture sensitiv…
View article: Utilizing Plant Tissue Culture Protocol for Propagation of Jatropha curcas- A Semi-arid Tree Species in Maiduguri, Nigeria
Utilizing Plant Tissue Culture Protocol for Propagation of Jatropha curcas- A Semi-arid Tree Species in Maiduguri, Nigeria Open
This study examines the in vitro propagation of Jatropha curcas, a drought resistant tree species valued for its medicinal uses, biofuel production, and soil rehabilitation in arid regions. The research addresses the challenges of natural …
View article: Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents
Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents Open
Twelve novel neo-tanshinlactone–chalcone hybrid molecules were constructed through a versatile methodology involving the Horner–Wadsworth–Emmons (HWE) olefination of 4-formyl- 2H -benzo [ h ]chromen-2-ones and phosphonic acid diethyl ester…
View article: Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis
Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis Open
Polo-like kinase-1 (PLK-1) is an essential mitotic serine/threonine (Ser/Thr) kinase that belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung cancer (NSCLC) via promotion of cell division. Therefore, PL…
View article: Visible light photoredox catalyzed synthesis of tetrahydrobenzofuranone: oxidative [3+2] cycloaddition of dicarbonyl and alkene
Visible light photoredox catalyzed synthesis of tetrahydrobenzofuranone: oxidative [3+2] cycloaddition of dicarbonyl and alkene Open
Visible-light-mediated formation of tetrahydrobenzofuranone by direct oxidative [3 + 2] cycloaddition via coupling between dimedone and chalcone using eosin-Y as a photoredox catalyst has been reported. The reaction takes place by a radica…
View article: An ultrasound assisted, ionic liquid-molecular iodine synergy driven efficient green synthesis of pyrrolobenzodiazepine-triazole hybrids as potential anticancer agents
An ultrasound assisted, ionic liquid-molecular iodine synergy driven efficient green synthesis of pyrrolobenzodiazepine-triazole hybrids as potential anticancer agents Open
Herein, we report an efficient and eco-friendly, ultrasound assisted synthetic strategy for the construction of diversified pyrrolobenzodiazepine-triazole hybrids, which are potentially pharmaceutically important scaffolds, via a domino re…
View article: Computational Screening of Plant-Derived Natural Products against SARS-CoV-2 Variants
Computational Screening of Plant-Derived Natural Products against SARS-CoV-2 Variants Open
The present study explores the efficacy of plant-derived natural products (PDNPs) against spike glycoproteins (S-glycoprotein) of SARS-CoV-2 variants using molecular docking, ADMET, molecular dynamics (MD) simulation and density-functional…
View article: Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis
Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis Open
Monu,1,2 Prachi Agnihotri,1 Mohd Saquib,1,2 Ashish Sarkar,1,2 Debolina Chakraborty,1,2 Uma Kumar,3 Sagarika Biswas1 1Council of Scientific and Industrial Research -Institute of Genomics & Integrative Biology (CSIR–IGIB), Delhi, 110007, Ind…
View article: Role of Cycle Threshold of RT-PCR in the Prediction of COVID-19 Cases
Role of Cycle Threshold of RT-PCR in the Prediction of COVID-19 Cases Open
Objectives: It is currently unclear whether SARS-CoV-2 Cycle threshold (Ct) values could be leveraged to guide patients’ clinical manifestations and management decisions. The present study was undertaken to observe whether RT-PCR Ct values…
View article: Design and Synthesis of Bioinspired Benzocoumarin‐Chalcones Chimeras as Potential Anti‐Breast Cancer Agents
Design and Synthesis of Bioinspired Benzocoumarin‐Chalcones Chimeras as Potential Anti‐Breast Cancer Agents Open
The design and synthesis of a library of natural product inspired benzocoumarin‐chalcones chimeras, as potent and selective, novel, anti‐breast cancer scaffold, is reported herein. Twenty‐one new chimeric molecules, 25 – 45 , were synthesi…
View article: Safe Use of Sodium Dodecyl Sulfate (SDS) to Deactivate SARS-CoV-2: An Evidence-Based Systematic Review
Safe Use of Sodium Dodecyl Sulfate (SDS) to Deactivate SARS-CoV-2: An Evidence-Based Systematic Review Open
Background: Coronavirus disease (COVID-19) has now morphed into the most serious healthcare challenge that the world has faced in a century. The coronavirus disease (COVID-19) was declared as a public health emergency of international conc…
View article: Primed for global coronavirus pandemic: Emerging research and clinical outcome
Primed for global coronavirus pandemic: Emerging research and clinical outcome Open
View article: A Study of Septorhinoplasty by Open Technique
A Study of Septorhinoplasty by Open Technique Open
Background: This study aimed to assess the reasons for which patients seek rhinoplasty, viz aesthetic, functional and psychosocial reasons. The study included 20 patients with traumatic, infective and congenital nasal deformities and were …
View article: Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment
Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment Open
View article: Sa1952 – Role of Low-Grade Inflammation in the Pathogenesis of Diarrhea-Predominant Irritable Bowel Syndrome (IBS) and Ibs-Like Symptoms in Patients with Ulcerative Colitis in Remission: An Evidence for Inflamed Gut in Pathogenesis of Ibs
Sa1952 – Role of Low-Grade Inflammation in the Pathogenesis of Diarrhea-Predominant Irritable Bowel Syndrome (IBS) and Ibs-Like Symptoms in Patients with Ulcerative Colitis in Remission: An Evidence for Inflamed Gut in Pathogenesis of Ibs Open
View article: Effect of aqueous extract and compost of invasive weed Ageratina adenophora on seed germination and seedling growth of some crops and weeds
Effect of aqueous extract and compost of invasive weed Ageratina adenophora on seed germination and seedling growth of some crops and weeds Open
A study was conducted to investigate the effects of invasive weed Ageratina adenophora on the seed germination and seedling growth of Triticum aestivum, Brassica campestris and on weeds Ageratum conyzoides, Bidens pilosa, Galinsoga parvifl…
View article: A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles
A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles Open
Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of d…
View article: Functional Outcome in Primary Nasolacrimal Duct Obstruction after Successful External Dacryocystorhinostomy Surgery
Functional Outcome in Primary Nasolacrimal Duct Obstruction after Successful External Dacryocystorhinostomy Surgery Open
Aim: To assess the functional outcomes of external dacryocystorhinostomy(DCR) surgery in symptomatic patient with primary nasolacrimal duct obstruction .Settings and Design: Prospective, clinical interventional studyMethods: This study was…
View article: Yield, NPK content and nutrient uptake of wheat as influenced by the application of acidulated rock phosphate.
Yield, NPK content and nutrient uptake of wheat as influenced by the application of acidulated rock phosphate. Open
View article: Cosmetic evaluation of surgical scars after external dacryocystorhinostomy
Cosmetic evaluation of surgical scars after external dacryocystorhinostomy Open
The external DCR is a highly effective and safe procedure and in view of low percentage of cases who complained of marked scarring in the present study, thus scarring should not be the main ground for deciding the approach to DCR surgery, …
View article: Allelopathic Effect of Artemisia Dubia Extracts on Seed Germination and Seedling Growth of Some Weeds and Winter Crops
Allelopathic Effect of Artemisia Dubia Extracts on Seed Germination and Seedling Growth of Some Weeds and Winter Crops Open
Allelopathic effects of aqueous extract of different plant parts (root, stem and leaf) of Artemisia dubia on seed germination and seedling growth of two winter crops (Triticum aestivum and Brassica campestries, and some associated weeds (B…