Mohib Uddin
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View article: Leukotriene receptors in GtoPdb v.2025.3
Leukotriene receptors in GtoPdb v.2025.3 Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [36, 39]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Delta subfamily in GtoPdb v.2025.3
Delta subfamily in GtoPdb v.2025.3 Open
PKCδ and PKCθ are PKC isoforms that are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.
View article: Chemokine receptors in GtoPdb v.2025.3
Chemokine receptors in GtoPdb v.2025.3 Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [460, 459, 32, 125]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically …
View article: Phosphatidylinositol kinases in GtoPdb v.2025.1
Phosphatidylinositol kinases in GtoPdb v.2025.1 Open
Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) cataly…
View article: Chemokine receptors in GtoPdb v.2025.1
Chemokine receptors in GtoPdb v.2025.1 Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [459, 458, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…
View article: Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2025.1
Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2025.1 Open
PI3K activation is one of the most important signal transduction pathways used to transmit signals from cell-surface receptors to regulate intracellular processes (cell growth, survival, proliferation and movement). PI3K catalytic (and reg…
View article: A severe asthma phenotype of excessive airway <i>Haemophilus influenzae</i> relative abundance associated with sputum neutrophilia
A severe asthma phenotype of excessive airway <i>Haemophilus influenzae</i> relative abundance associated with sputum neutrophilia Open
Background Severe asthma (SA) encompasses several clinical phenotypes with a heterogeneous airway microbiome. We determined the phenotypes associated with a low α‐diversity microbiome. Methods Metagenomic sequencing was performed on sputum…
View article: Selective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro
Selective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro Open
Background Thyroid cancer is the most common endocrine malignancy. Current therapies are successful, however some patients progress to therapeutically refractive disease. The immunotherapeutic potential of the CXCL8-chemokine/CXCR2-chemoki…
View article: Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk Open
Rationale: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. Objectives: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. Methods: Oroph…
View article: Phosphatidylinositol kinases in GtoPdb v.2023.1
Phosphatidylinositol kinases in GtoPdb v.2023.1 Open
Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) cataly…
View article: Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2023.1
Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2023.1 Open
PI3K activation is one of the most important signal transduction pathways used to transmit signals from cell-surface receptors to regulate intracellular processes (cell growth, survival, proliferation and movement). PI3K catalytic (and reg…
View article: Chemokine receptors in GtoPdb v.2023.1
Chemokine receptors in GtoPdb v.2023.1 Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [438, 437, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…
View article: Delta subfamily in GtoPdb v.2023.1
Delta subfamily in GtoPdb v.2023.1 Open
PKCδ and PKCθ are PKC isoforms that are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.
View article: Leukotriene receptors in GtoPdb v.2023.1
Leukotriene receptors in GtoPdb v.2023.1 Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [35, 38]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Anti-inflammatory effects of salbutamol on human bronchial epithelial cells stimulated by cigarette smoke extract
Anti-inflammatory effects of salbutamol on human bronchial epithelial cells stimulated by cigarette smoke extract Open
Cigarette smoking, the major cause of chronic obstructive pulmonary disease (COPD), induces activation of pro-inflammatory pathways in the airway epithelium. Salbutamol, a selective and short-acting β2-adrenoceptor agonist, is used for bro…
View article: A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes
A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes Open
Asthma is a heterogeneous disease with multiple clinical presentations (phenotypes) [1]. Neutrophilic asthma is characterized by increased sputum neutrophils and generally has a poor response to corticosteroids and limited other therapeuti…
View article: Omega‐3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non‐alcoholic fatty liver disease
Omega‐3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non‐alcoholic fatty liver disease Open
Fibrates and omega‐3 polyunsaturated acids are used for the treatment of hypertriglyceridemia but have not demonstrated consistent effects on cardiovascular (CV) risk. In this study, we investigate how these two pharmacological agents infl…
View article: Phosphatidylinositol kinases in GtoPdb v.2021.3
Phosphatidylinositol kinases in GtoPdb v.2021.3 Open
Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) cataly…
View article: Discordant use of short‐acting β<sub>2</sub> agonists in children and adults with severe, uncontrolled asthma from the U‐BIOPRED cohort
Discordant use of short‐acting β<sub>2</sub> agonists in children and adults with severe, uncontrolled asthma from the U‐BIOPRED cohort Open
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View article: Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [431, 430, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…
View article: Instability of sputum molecular phenotypes in U-BIOPRED severe asthma
Instability of sputum molecular phenotypes in U-BIOPRED severe asthma Open
At 1 year, 45% of severe asthma change molecular phenotype as determined by sputum transcriptomic analysis. Together with concomitant shift in sputum granulocytic markers, this may indicate variability of driving mechanisms in this unstabl…
View article: Delta subfamily (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Delta subfamily (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
PKCδ and PKCθ are PKC isoforms that are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.
View article: Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [661]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differ…