Mohit Pandey
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View article: DNAR-06. Discovery and development of novel CNS-penetrating PARP1-selective inhibitors
DNAR-06. Discovery and development of novel CNS-penetrating PARP1-selective inhibitors Open
Poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA damage repair (DDR) and inhibition of PARP1 specifically has been shown to be an effective treatment for cancers with DDR deficiencies, such as BRCA mutations. First generation PARP…
View article: Black bone magnetic resonance imaging in clinical practice: Systematic review of current perspectives and insights
Black bone magnetic resonance imaging in clinical practice: Systematic review of current perspectives and insights Open
Magnetic resonance imaging (MRI) has proven its strengths in soft-tissue imaging, but advancements in imaging techniques have now enhanced bone visualization. This review evaluates the effectiveness and reliability of black bone MRI for de…
View article: Why Pool When You Can Flow? Active Learning with GFlowNets
Why Pool When You Can Flow? Active Learning with GFlowNets Open
The scalability of pool-based active learning is limited by the computational cost of evaluating large unlabeled datasets, a challenge that is particularly acute in virtual screening for drug discovery. While active learning strategies suc…
View article: Performance of Wheat Varieties in Malia Dubia (Melia azedarach L.) Based Agroforestry System in Bundelkhand Region
Performance of Wheat Varieties in Malia Dubia (Melia azedarach L.) Based Agroforestry System in Bundelkhand Region Open
The integration of suitable tree species with crops not only diversifies farm income but also helps in mitigating the adverse effects of climate change and erratic rainfall patterns. Successful agroforestry adoption depends largely on choo…
View article: A SCALE TO MEASURE THE ENTREPRENEURIAL BEHAVIOUR OF TOMATO GROWERS
A SCALE TO MEASURE THE ENTREPRENEURIAL BEHAVIOUR OF TOMATO GROWERS Open
The present study was conducted to develop and standardize a reliable and valid scale to measure the entrepreneurial behavior of tomato growers. The Normalized Rank Order Method, as recommended by Guilford (1954), was used for scale develo…
View article: Public-Private Partnerships in Agricultural Extension: Opportunities and Challenges
Public-Private Partnerships in Agricultural Extension: Opportunities and Challenges Open
Public-private partnerships (PPPs) in agricultural extension have emerged as a critical strategy to modernize knowledge dissemination, improve service efficiency, and strengthen farmer-market linkages amid shrinking public resources and gr…
View article: Radiology in Emergency Medicine in Three Common Usages
Radiology in Emergency Medicine in Three Common Usages Open
Emergency medicine relies profoundly on radiological imaging to provide crucial diagnostic insights for the swift and accurate assessment and management of patients grappling with traumatic injuries, acute strokes, and acute abdominal cond…
View article: Pretraining Generative Flow Networks with Inexpensive Rewards for Molecular Graph Generation
Pretraining Generative Flow Networks with Inexpensive Rewards for Molecular Graph Generation Open
Generative Flow Networks (GFlowNets) have recently emerged as a suitable framework for generating diverse and high-quality molecular structures by learning from rewards treated as unnormalized distributions. Previous works in this framewor…
View article: Magnetic Resonance Imaging (MRI) Insights into Brain Morphology and Connectivity Disruptions in Schizophrenia
Magnetic Resonance Imaging (MRI) Insights into Brain Morphology and Connectivity Disruptions in Schizophrenia Open
This review explores the transformative impact of Magnetic Resonance Imaging (MRI) on understanding schizophrenia. Structural MRI has unveiled significant alterations in brain regions like the hippocampus and prefrontal cortex, offering de…
View article: A general class of improved population variance estimators under non-sampling errors using calibrated weights in stratified sampling
A general class of improved population variance estimators under non-sampling errors using calibrated weights in stratified sampling Open
This paper proposes a new calibration estimator for population variance within a stratified two-phase sampling design. It takes into account random non-response and measurement errors, specifically applying this method to estimate the vari…
View article: KNOWLEDGE AND ADOPTION LEVEL OF FARMERS WITH RESPECT TO PACKAGE OF PRACTICES OF BASMATI RICE CULTIVATION
KNOWLEDGE AND ADOPTION LEVEL OF FARMERS WITH RESPECT TO PACKAGE OF PRACTICES OF BASMATI RICE CULTIVATION Open
The present study was conducted to find out the knowledge level of basmati rice growers in Shahjahanpur district of Uttar Pradesh. The data was collected through personal interview schedule from the basmati rice growers for the investigati…
View article: PROTACable is an Integrative Computational Pipeline of 3-D Modeling and Deep Learning to Automate the De Novo Design of PROTACs
PROTACable is an Integrative Computational Pipeline of 3-D Modeling and Deep Learning to Automate the De Novo Design of PROTACs Open
Proteolysis-targeting chimeras (PROTACs) that engages two biological targets at once is a promising technology in degrading clinically relevant protein targets. Since factors that influence the biological activities of PROTACs are more com…
View article: TacoGFN: Target-conditioned GFlowNet for Structure-based Drug Design
TacoGFN: Target-conditioned GFlowNet for Structure-based Drug Design Open
Searching the vast chemical space for drug-like molecules that bind with a protein pocket is a challenging task in drug discovery. Recently, structure-based generative models have been introduced which promise to be more efficient by learn…
View article: Impact of Organic Farming on the Livelihood of Organic Farmers in Manipur
Impact of Organic Farming on the Livelihood of Organic Farmers in Manipur Open
The study was conducted to evaluate how organic farming has affected the livelihood of organic farmers. The research was carried out in Churachandpur and Imphal West districts of Manipur. The ex-post facto research design was adopted for t…
View article: A Review on Yield Gap Analysis of Millets in India
A Review on Yield Gap Analysis of Millets in India Open
Millet is a healthy grain that is high in vitamins, minerals, and fibre. It is also gluten-free and has a low glycemic index, making it a suitable diet for persons with gluten intolerance or diabetes. Millet is an important crop for small …
View article: Review of Imaging Autism Spectrum Disorders with Magnetic Resonance Imaging Techniques
Review of Imaging Autism Spectrum Disorders with Magnetic Resonance Imaging Techniques Open
The pattern of autism spectrum disorder (ASD) at early stage may be identified, but difficult to conclude to some extent with specific classification. Multiple researches and reviews published in recent years to exactly define ASD patterns…
View article: Two Decadal Experiences in Managing Combined Obstetric Vesicovaginal and Rectovaginal Fistulas: A Study From Northern Indian Tertiary Hospital
Two Decadal Experiences in Managing Combined Obstetric Vesicovaginal and Rectovaginal Fistulas: A Study From Northern Indian Tertiary Hospital Open
All cases had effective VVF and RVF repairs, and both urine and faecal incontinence were completely cured. This study suggests the collaborative engagement of a urologist and a surgical gastroenterologist results in an advantageous outcome…
View article: Novel Inhibitors of androgen receptor's DNA binding domain identified using an ultra‐large virtual screening
Novel Inhibitors of androgen receptor's DNA binding domain identified using an ultra‐large virtual screening Open
Androgen receptor (AR) inhibition remains the primary strategy to combat the progression of prostate cancer (PC). However, all clinically used AR inhibitors target the ligand‐binding domain (LBD), which is highly susceptible to truncations…
View article: Shear wave velocity variation across the South Almora Thrust, Kumaon Himalaya using Joint Inversion of Horizontal-to-Vertical Spectral Ratio (HVSR) and Dispersion curve
Shear wave velocity variation across the South Almora Thrust, Kumaon Himalaya using Joint Inversion of Horizontal-to-Vertical Spectral Ratio (HVSR) and Dispersion curve Open
The Horizontal-to-Vertical Spectral Ratio (HVSR) method and Multi-Channel Analysis of Surface Waves (MASW) method are commonly used as a joint fit technique to retrieve the 1-D shear wave velocity. The Kumaon Himalaya consists of major thr…
View article: Identification of Point Diffractor body placed in dipping Vertically Transverse Isotropic medium using Reverse Time Migration
Identification of Point Diffractor body placed in dipping Vertically Transverse Isotropic medium using Reverse Time Migration Open
Numerical modelling has been proved as an incomparable tool to understand the structure of the earth and the processes beneath the earth’s surface. Finite difference method (FDM) plays a dominant role among various numerical methods …
View article: PurificationDB: database of purification conditions for proteins
PurificationDB: database of purification conditions for proteins Open
The isolation of proteins of interest from cell lysates is an integral step to study protein structure and function. Liquid chromatography is a technique commonly used for protein purification, where the separation is performed by exploiti…
View article: Multibody molecular docking on a quantum annealer
Multibody molecular docking on a quantum annealer Open
Molecular docking, which aims to find the most stable interacting configuration of a set of molecules, is of critical importance to drug discovery. Although a considerable number of classical algorithms have been developed to carry out mol…
View article: Ligand Binding Prediction Using Protein Structure Graphs and Residual Graph Attention Networks
Ligand Binding Prediction Using Protein Structure Graphs and Residual Graph Attention Networks Open
Computational prediction of ligand–target interactions is a crucial part of modern drug discovery as it helps to bypass high costs and labor demands of in vitro and in vivo screening. As the wealth of bioactivity data accumulates, it provi…
View article: Task and Sales Manager Web Application
Task and Sales Manager Web Application Open
The purpose of the Web Application and Sales Manager Web application is to automate the existing hands-on system with the help of fully computerized software and software, to meet their needs, so that their important data / information is …
View article: Ligand Binding Prediction using Protein Structure Graphs and Residual Graph Attention Networks
Ligand Binding Prediction using Protein Structure Graphs and Residual Graph Attention Networks Open
Motivation Computational prediction of ligand-target interactions is a crucial part of modern drug discovery as it helps to bypass high costs and labor demands of in vitro and in vivo screening. As the wealth of bioactivity data accumulate…