Mohiuddin Quadir
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View article: Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells
Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development
Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development Open
Arabinoxylans (AX) are functional biopolymers, the main non-starch polysaccharides in cereals and other plants. AX is composed of xylose and arabinose, and the ester-linkage of ferulic acid to arabinose confers its bioactive properties. Th…
View article: Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells
Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as Gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development
Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development Open
Arabinoxylans (AX) are functional biopolymers, the main non-starch polysaccharides in cereals and other plants. AX is composed of xylose and arabinose, and the ester-linkage of ferulic acid to arabinose confers its bioactive properties. Th…
View article: From Plants to Plants: Plant-Derived Biological Polymers as Sustainable and Safe Nanocarriers for Direct Delivery of DNA to Plant Cells
From Plants to Plants: Plant-Derived Biological Polymers as Sustainable and Safe Nanocarriers for Direct Delivery of DNA to Plant Cells Open
Sustainable plant-derived biopolymers cellulose nanocrystals (CNC) and Zein protein were used to deliver plasmid DNA with a reporter GFP gene (pDNA) to plant cells. CNC and Zein were modified with the cationic agent 2,3-epoxypropyltrimethy…
View article: An Evaluation of EVM-Compatible Blockchain Platforms for Trade Finance
An Evaluation of EVM-Compatible Blockchain Platforms for Trade Finance Open
Blockchain, such as Bitcoin and Ethereum, has received significant attention and widespread usage in recent years. However, blockchain scalability has emerged as a challenging issue. This article explores the existing scalability options f…
View article: Substrate structure modulates the catalytic dynamics of HDAC8 at the single-molecule level
Substrate structure modulates the catalytic dynamics of HDAC8 at the single-molecule level Open
Single-molecule analysis reveals how ligand modifications synergistically control HDAC8 catalysis by stabilizing active conformations, providing mechanistic insights into ligand-regulated enzymatic catalysis.
View article: EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment Open
Background Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity have limited its uti…
View article: pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model
pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model Open
Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing. Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the f…
View article: Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes
Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes Open
Self-assembled materials capable of modulating their assembly properties in response to specific enzymes play a pivotal role in advancing ‘intelligent’ encapsulation platforms for biotechnological applications. Here, we introduce a previou…
View article: Benefits and Pitfalls of a Glycosylation Inhibitor Tunicamycin in the Therapeutic Implication of Cancers
Benefits and Pitfalls of a Glycosylation Inhibitor Tunicamycin in the Therapeutic Implication of Cancers Open
The aberrant glycosylation is a hallmark of cancer progression and chemoresistance. It is also an immune therapeutic target for various cancers. Tunicamycin (TM) is one of the potent nucleoside antibiotics and an inhibitor of aberrant glyc…
View article: Benefits and Pitfalls of a Glycosylation Inhibitor Tunicamycin in Therapeutic Implication of Cancers
Benefits and Pitfalls of a Glycosylation Inhibitor Tunicamycin in Therapeutic Implication of Cancers Open
The aberrant glycosylation is a hallmark of cancer progression and chemoresistance. It is also an immune therapeutic target for various cancers. Tunicamycin (TM) is one of the potent nucleo-side antibiotics and an inhibitor of aberrant gly…
View article: Extracellular Signal-Regulated Kinase Inhibitor SCH772984 Augments the Anti-Cancer Effects of Gemcitabine in Nanoparticle Form in Pancreatic Cancer Models.
Extracellular Signal-Regulated Kinase Inhibitor SCH772984 Augments the Anti-Cancer Effects of Gemcitabine in Nanoparticle Form in Pancreatic Cancer Models. Open
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor response to the limited treatment options currently available. Hence, there is a need to identify new agents that could enhance the efficacy of existing treatments. Th…
View article: Furan-rich, biobased transfection agents as potential oligomeric candidates for intracellular plasmid DNA delivery
Furan-rich, biobased transfection agents as potential oligomeric candidates for intracellular plasmid DNA delivery Open
Derived from furan diacrylate, the first examples of biobased gene transfection agents.
View article: Nano Boron Oxide and Zinc Oxide Doped Lignin Containing Cellulose Nanocrystals Improve the Thermal, Mechanical and Flammability Properties of High-Density Poly(ethylene)
Nano Boron Oxide and Zinc Oxide Doped Lignin Containing Cellulose Nanocrystals Improve the Thermal, Mechanical and Flammability Properties of High-Density Poly(ethylene) Open
The widely used high-density polyethylene (HDPE) polymer has inadequate mechanical and thermal properties for structural applications. To overcome this challenge, nano zinc oxide (ZnO) and nano boron oxide (B2O3) doped lignin-containing ce…
View article: ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation
ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation Open
Prostate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease recurrence, metastatic advancement, multi-organ failure, and dea…
View article: pH-responsive Targeted nanoparticles release ERK-inhibitor in the hypoxic zone Sensitizes Gemcitabine in Mutant K-Ras-addicted Pancreatic Cancer
pH-responsive Targeted nanoparticles release ERK-inhibitor in the hypoxic zone Sensitizes Gemcitabine in Mutant K-Ras-addicted Pancreatic Cancer Open
Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing. Therefore, despite suboptimal clinical effects, Gemcitabine (GEM) remains the f…
View article: Robotic painting: mimicking human applicators
Robotic painting: mimicking human applicators Open
Robotically assisted painting is widely used for spray and dip applications. However, use of robots for coating substrates using a roller applicator has not been systematically investigated. We showed for the first time, a generic robot ar…
View article: Bioinspired Materials for Wearable Devices and Point-of-Care Testing of Cancer
Bioinspired Materials for Wearable Devices and Point-of-Care Testing of Cancer Open
Wearable, point-of-care diagnostics, and biosensors are on the verge of bringing transformative changes in detection, management, and treatment of cancer. Bioinspired materials with new forms and functions have frequently been used, in bot…
View article: The role of CCNs in controlling cellular communication in the tumor microenvironment
The role of CCNs in controlling cellular communication in the tumor microenvironment Open
The Cellular communication network (CCN) family of growth regulatory factors comprises six secreted matricellular proteins that promote signal transduction through cell-cell or cell-matrix interaction. The diversity of functionality betwee…
View article: CCN5 Activation by free or encapsulated-EGCG is required to Render Triple-negative breast cancer cell Viability and Tumor Progression
CCN5 Activation by free or encapsulated-EGCG is required to Render Triple-negative breast cancer cell Viability and Tumor Progression Open
Background and Purpose: Epigallocatechin-3-gallate (EGCG) has been considered an anticancer agent despite conflicting and discrepant bioavailability views. EGCG impairs the viability and self-renewal capacity of triple-negative breast canc…
View article: A Low-cost Robot with Autonomous Recharge and Navigation for Weed\n Control in Fields with Narrow Row Spacing
A Low-cost Robot with Autonomous Recharge and Navigation for Weed\n Control in Fields with Narrow Row Spacing Open
Modern herbicide application in agricultural settings typically relies on\neither large scale sprayers that dispense herbicide over crops and weeds alike\nor portable sprayers that require labor intensive manual operation. The former\nmeth…
View article: A Low-cost Robot with Autonomous Recharge and Navigation for Weed Control in Fields with Narrow Row Spacing
A Low-cost Robot with Autonomous Recharge and Navigation for Weed Control in Fields with Narrow Row Spacing Open
Modern herbicide application in agricultural settings typically relies on either large scale sprayers that dispense herbicide over crops and weeds alike or portable sprayers that require labor intensive manual operation. The former method …
View article: CCN5 activation by free or encapsulated EGCG is required to render triple‐negative breast cancer cell viability and tumor progression
CCN5 activation by free or encapsulated EGCG is required to render triple‐negative breast cancer cell viability and tumor progression Open
Epigallocatechin‐3‐gallate (EGCG) has been considered an anticancer agent despite conflicting and discrepant bioavailability views. EGCG impairs the viability and self‐renewal capacity of triple‐negative breast cancer (TNBC) cells and make…
View article: The Impact of Nanoparticles on the Immune System: A Gray Zone of Nanomedicine
The Impact of Nanoparticles on the Immune System: A Gray Zone of Nanomedicine Open
Since the early days marking the first use of nanomedicine in the early 80s, there has been a meaningful change in the scientific field involving the Fabrication, characterization, and application of nanomaterials to treat many diseases, i…
View article: Silane compatibilzation to improve the dispersion, thermal and mechancial properties of cellulose nanocrystals in poly (ethylene oxide)
Silane compatibilzation to improve the dispersion, thermal and mechancial properties of cellulose nanocrystals in poly (ethylene oxide) Open
Cellulose nanocrystal (CNC) has potential to be used as a reinforcement in polymeric nanocomposites because of their inherent biodegradability, universal accessibility, and superior mechanical properties. The most crucial challenge faced i…
View article: Risk of COVID-19 Spread and Mitigation Strategies in Public Transportation Sector
Risk of COVID-19 Spread and Mitigation Strategies in Public Transportation Sector Open
The world is trying to recover from once in the COVID-19 pandemic, which has a higher mortality rate than the common flu. However, the threat of different variants is still affecting us in a different capacity. Several preventive measures …
View article: Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin
Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin Open
The molecular architecture of pH-responsive amphiphilic block copolymers, their self-assembly behavior to form nanoparticles (NPs), and doxorubicin (DOX)-loading technique govern the extent of DOX-induced cardiotoxicity. We observed that t…