Muhammad Abdullah Ali
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View article: Trends and disparities in chronic ischemic heart disease mortality among adult cancer patients: a nationwide CDC WONDER analysis (1999–2020)
Trends and disparities in chronic ischemic heart disease mortality among adult cancer patients: a nationwide CDC WONDER analysis (1999–2020) Open
Background Chronic ischemic heart disease (IHD) is a leading cause of cardiovascular-related mortality worldwide, with a growing burden among cancer patients due to shared risk factors and treatment-related Cardiotoxicity. However, nationw…
View article: Safety and efficacy of darolutamide in combination with androgen-deprivation therapy for prostate cancer: a systematic review and meta-analysis
Safety and efficacy of darolutamide in combination with androgen-deprivation therapy for prostate cancer: a systematic review and meta-analysis Open
Background: Prostate cancer is the second most common cancer in men. Androgen deprivation therapy (ADT) is the standard treatment, but many patients develop resistance, leading to metastatic castration-resistant prostate cancer (CRPC). Dar…
View article: Diagnostic Performance of Metagenomic Next-Generation Sequencing (mNGS) and Culture in Infected Pancreatic Necrosis: A Systematic Review and Meta-Analysis
Diagnostic Performance of Metagenomic Next-Generation Sequencing (mNGS) and Culture in Infected Pancreatic Necrosis: A Systematic Review and Meta-Analysis Open
Background Infected pancreatic necrosis (IPN) is a severe complication of acute pancreatitis, requiring prompt diagnosis. Conventional microbial culture, the current gold standard, has limitations in sensitivity and turnaround time. Metage…
View article: Iatrogenic Pancreatitis Post‐Cholecystectomy—A Surgical Paradox: When Cholecystectomy Leads to Pancreatitis, a Case Report
Iatrogenic Pancreatitis Post‐Cholecystectomy—A Surgical Paradox: When Cholecystectomy Leads to Pancreatitis, a Case Report Open
Iatrogenic pancreatitis is a rare but serious complication of laparoscopic cholecystectomy. Prompt recognition and aggressive management are crucial in young patients, as in this 23‐year‐old case. Early intervention can prevent severe cons…
View article: Trends and Demographics of Liver Fibrosis and Cirrhosis‐Related Mortality Among Adults Living in the United States From 1999 to 2020: A CDC Wonder Analysis
Trends and Demographics of Liver Fibrosis and Cirrhosis‐Related Mortality Among Adults Living in the United States From 1999 to 2020: A CDC Wonder Analysis Open
Introduction Liver cirrhosis, the fifth leading cause of adult mortality, involves progressive, irreversible liver fibrosis and loss of function. Its rising prevalence necessitates studying trends, identifying high‐risk groups, and enhanci…
View article: Unraveling Delayed Puberty: A Rare Case of Congenital Hypogonadotropic Hypogonadism Masked by Celiac Disease and Plummer–Vinson Syndrome
Unraveling Delayed Puberty: A Rare Case of Congenital Hypogonadotropic Hypogonadism Masked by Celiac Disease and Plummer–Vinson Syndrome Open
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that results in delayed puberty and infertility due to impaired secretion of gonadotropin‐releasing hormone (GnRH). Here, we present a case of a 25‐year‐old male with a know…
View article: Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis
Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis Open
Lemborexant demonstrates significant efficacy in improving sleep parameters in patients with insomnia and has a generally favorable safety profile. These findings support its role as an effective pharmacological option. Further high-qualit…
View article: Efficacy and Safety of Oral Immunotherapy for Peanut Allergy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Oral Immunotherapy for Peanut Allergy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Introduction: Peanut allergy is a common and potentially life-threatening condition affecting up to 2% of children in Western countries. Management traditionally relied on avoidance, but in 2020, the FDA-approved peanut oral immunotherapy …
View article: Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials
Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials Open
Introduction Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as…
View article: Trends and Demographics of Vascular Intestinal Diseases‐Related Mortality Among Adults Living in United States From 1999 to 2020; A CDC Wonder Analysis
Trends and Demographics of Vascular Intestinal Diseases‐Related Mortality Among Adults Living in United States From 1999 to 2020; A CDC Wonder Analysis Open
Introduction Vascular intestinal disorders (VID), including mesenteric ischemia, ischemic colitis, and intestinal angiodysplasia, have a global incidence of 8.11/100 000/year and a mortality of 1.26/100 000/year (15.5% death rate), rising …
View article: Long-term efficacy and safety of endovascular thrombectomy for acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis
Long-term efficacy and safety of endovascular thrombectomy for acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis Open
Background: Endovascular thrombectomy (EVT) improves functional outcomes at 90 days in patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, its long-term efficacy and safety beyond 90 days remain unclear. O…
View article: Cefuroxime-induced toxic epidermal necrolysis in a 4-year-old male child: a case report
Cefuroxime-induced toxic epidermal necrolysis in a 4-year-old male child: a case report Open
Introduction: Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous reaction characterized by extensive epidermal detachment and multi-organ involvement. It is most commonly triggered by drugs, including antibiotics su…
View article: Effect of dexamethasone and lidocaine combination on incidence of post-operative sore throat: A meta-analysis and trial sequential analysis
Effect of dexamethasone and lidocaine combination on incidence of post-operative sore throat: A meta-analysis and trial sequential analysis Open
The dexamethasone-lidocaine combination suggests a clinically meaningful reduction in POST compared to dexamethasone alone, with consistent effects across studies. While not impacting hoarseness and cough, these robust findings support ado…
View article: Comparative efficacy and safety of no-touch versus conventional vein harvesting techniques in coronary artery bypass grafting: a systematic review and meta-analysis
Comparative efficacy and safety of no-touch versus conventional vein harvesting techniques in coronary artery bypass grafting: a systematic review and meta-analysis Open
Objective This meta-analysis aims to compare the clinical outcomes of the no-touch (NT) and conventional (CON) vein harvesting techniques in patients undergoing coronary artery bypass grafting (CABG). Methods We conducted a systematic revi…
View article: Transcatheter Versus Surgical Approach for the Treatment of Aortic Stenosis in Patients With Concomitant Coronary Artery Disease: A Systematic Review and Meta‐Analysis
Transcatheter Versus Surgical Approach for the Treatment of Aortic Stenosis in Patients With Concomitant Coronary Artery Disease: A Systematic Review and Meta‐Analysis Open
Aortic stenosis (AS) with concomitant coronary artery disease (CAD) requires an approach that addresses both valvular and coronary pathology. While surgical aortic valve replacement (SAVR) with coronary artery bypass graft (CABG) has long …
View article: Efficacy and Safety of Prothrombin Complex Concentrate Compared to Fresh Frozen Plasma in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Prothrombin Complex Concentrate Compared to Fresh Frozen Plasma in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Coagulopathy and bleeding are common complications following cardiac surgery, often requiring the use of hemostatic agents such as prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP). This systematic review and meta-analysis…
View article: Head-to-Head: Recombinant Human Prourokinase Versus Intravenous Thrombolytics in Acute Ischemic Stroke Within 4.5 Hours – A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials
Head-to-Head: Recombinant Human Prourokinase Versus Intravenous Thrombolytics in Acute Ischemic Stroke Within 4.5 Hours – A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials Open
Background Intravenous thrombolytics are essential for achieving timely reperfusion in acute ischemic stroke (AIS), with alteplase historically serving as the standard of care. Emerging alternatives like recombinant human prourokinase (rhP…
View article: Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open
Background Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological damage. Recombinant human prourokinase (rhPro‐UK) has emerged as a promising alternative to alteplase, with potential effica…
View article: Efficacy and Safety of Distal Radial Artery Access versus Proximal Radial Artery Access for Cardiac Procedures: A Systematic Review and Meta-Analysis
Efficacy and Safety of Distal Radial Artery Access versus Proximal Radial Artery Access for Cardiac Procedures: A Systematic Review and Meta-Analysis Open
Objective: Cardiac catheterization using the distal radial artery (DRA) access, at the level of the anatomical snuff box post-radial artery bifurcation, may be linked to a lower rate of arterial occlusion and better hemostasis. In this met…
View article: Exploring the interplay between anxiety and academic procrastination: An institution-based cross-sectional study from Pakistan
Exploring the interplay between anxiety and academic procrastination: An institution-based cross-sectional study from Pakistan Open
Background: Procrastination, the unnecessary delay of tasks, is common among college students, especially in academic settings. Academic procrastination often leads to last-minute rushes and increased anxiety. The relationship between proc…
View article: Irritable Bowel Syndrome in Two Different Socioeconomic Groups in Pakistan
Irritable Bowel Syndrome in Two Different Socioeconomic Groups in Pakistan Open
Irritable bowel syndrome (lBS) in outpatient department in Social Security teaching hospital and Surgimed hospital Lahore and the comparison of the two groups along with their comparison with the western data. 163 patients in social securi…