Mohsen Navari
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View article: Molecular Profiling of Follicular Helper T-Cell Lymphomas
Molecular Profiling of Follicular Helper T-Cell Lymphomas Open
Follicular helper T-cell Lymphomas (FH-TCL) refers to a group of peripheral T-cell lymphomas (PTCLs) that phenotypically shows T follicular helper cell markers. These tumors morphologically are heterogeneous and correspond to angioimmunobl…
View article: Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome
Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome Open
View article: Conventional PCR-based versus next-generation sequencing-based approach for T-cell receptor γ gene clonality assessment in mature T-cell lymphomas: A phase 3 diagnostic accuracy study
Conventional PCR-based versus next-generation sequencing-based approach for T-cell receptor γ gene clonality assessment in mature T-cell lymphomas: A phase 3 diagnostic accuracy study Open
Background: Clonality assessment is currently the major molecular analysis utilized to support the diagnosis of suspicious lymphoid malignancies. Clonal rearrangements of the V-J segments of T-cell receptor G chain locus (TCRγ or TRG) have…
View article: Single-Step IGHV Next-Generation Sequencing Detects Clonality and Somatic Hypermutation in Lymphoid Malignancies: A Phase III Diagnostic Accuracy Study
Single-Step IGHV Next-Generation Sequencing Detects Clonality and Somatic Hypermutation in Lymphoid Malignancies: A Phase III Diagnostic Accuracy Study Open
Background: Multiplex PCR based on consensus primers followed by capillary electrophoresis and Sanger sequencing are considered as the gold standard method for the evaluation of clonality and somatic hypermutation in lymphoid malignancies.…
View article: Use of Next Generation Sequencing to Define the Origin of Primary Myelofibrosis
Use of Next Generation Sequencing to Define the Origin of Primary Myelofibrosis Open
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) characterized by progressive bone marrow sclerosis, extra-medullary hematopoiesis, and possible transformation to acute leukemia. In the last decade, the molecular …
View article: Molecular Profiling of Kenyan Acute Myeloid Leukemia Patients
Molecular Profiling of Kenyan Acute Myeloid Leukemia Patients Open
Acute myeloid leukemia (AML) is an infrequent disease, and it is associated with high morbidity and mortality. It harbors a unique configuration of cytogenetic abnormalities and molecular mutations that can be detected using microscopic an…
View article: T-Cell Receptor Dependent and Independent NF-kappa B Activation is a Prognostic Marker and a Therapeutic Target in Peripheral T-cell Lymphoma Not Otherwise Specified
T-Cell Receptor Dependent and Independent NF-kappa B Activation is a Prognostic Marker and a Therapeutic Target in Peripheral T-cell Lymphoma Not Otherwise Specified Open
Peripheral T-cell lymphomas not otherwise specified (PTCL/NOS) is the commonest subtype of PTCL. NF–kB related molecules have been found to be variably expressed in PTCL/NOS, suggesting a potential involvement of the NF–kB system in their …
View article: COVID-19 Vaccine: Between Myth and Truth
COVID-19 Vaccine: Between Myth and Truth Open
Since December 2019, a pandemic caused by the newly identified SARS-CoV-2 spread across the entire globe, causing 364,191,494 confirmed cases of COVID-19 to date. SARS-CoV-2 is a betacoronavirus, a positive-sense, single-stranded RNA virus…
View article: Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma
Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma Open
Altered cellular energetic metabolism has recently emerged as important feature of neoplastic cells. Indeed, interfering with cancer cell metabolism might represent a suitable therapeutic strategy. In this study, we aimed to assess glucose…
View article: Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma
Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma Open
Due to the high expression of P-selectin glycoprotein ligand-1 (PSGL-1) in lymphoproliferative disorders and in multiple myeloma, it has been considered as a potential target for humoral immunotherapy, as well as an immune checkpoint inhib…
View article: Co‐administration of 2’3’-cGAMP STING activator and CpG-C adjuvants with a mutated form of HPV 16 E7 protein leads to tumor growth inhibition in the mouse model
Co‐administration of 2’3’-cGAMP STING activator and CpG-C adjuvants with a mutated form of HPV 16 E7 protein leads to tumor growth inhibition in the mouse model Open
View article: Cross-Immunization Against Respiratory Coronaviruses May Protect Children From SARS-CoV2: More Than a Simple Hypothesis?
Cross-Immunization Against Respiratory Coronaviruses May Protect Children From SARS-CoV2: More Than a Simple Hypothesis? Open
In January 2020, a new coronavirus was identified as responsible for a pandemic acute respiratory syndrome. The virus demonstrated a high infectious capability and not-neglectable mortality in humans. However, similarly to previous SARS an…
View article: Gene expression profile predicts response to the combination of tosedostat and low-dose cytarabine in elderly AML
Gene expression profile predicts response to the combination of tosedostat and low-dose cytarabine in elderly AML Open
Tosedostat is an orally administered metalloenzyme inhibitor with antiproliferative and antiangiogenic activity against hematological and solid human cancers. Clinical activity has been demonstrated in relapsed acute myeloid leukemia (AML)…
View article: Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases
Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases Open
MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL . Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive…
View article: Lead(II) biosorption from aqueous solutions by Trichoderma fungus: equilibrium and thermodynamic study
Lead(II) biosorption from aqueous solutions by Trichoderma fungus: equilibrium and thermodynamic study Open
View article: Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma Open
View article: Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets Open
Lennert lymphoma (LL) is a lymphoepithelioid morphological variant of peripheral T-cell lymphoma-not otherwise specified (PTCL/NOS), clinically characterized by better prognosis if compared with other PTCL/NOS. Although well characterized …
View article: Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas
Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas Open
View article: Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas
Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas Open
Epstein–Barr virus (EBV) is a human γ-herpesvirus implicated in several human malignancies, including a wide range of lymphomas. Several molecules encoded by EBV in its latent state are believed to be related to EBV-induced lymphomagenesis…
View article: Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients
Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients Open
Myeloid sarcomas (MS) are tumors composed by myeloid elements and developing outside bone marrow. The prognosis is overall poor, only stem cell transplantation being consistently reposted as a potentially curative approach. In this study w…
View article: MicroRNAs sequencing unveils distinct molecular subgroups of plasmablastic lymphoma
MicroRNAs sequencing unveils distinct molecular subgroups of plasmablastic lymphoma Open
Plasmablastic lymphoma (PBL) is an aggressive lymphoma, often arising in the context of immunodeficiency and associated with Epstein-Barr virus (EBV) infection. The most frequently detected genetic alteration is the deregulation of MYC<…
View article: Unveiling Another Missing Piece in EBV-Driven Lymphomagenesis: EBV-Encoded MicroRNAs Expression in EBER-Negative Burkitt Lymphoma Cases
Unveiling Another Missing Piece in EBV-Driven Lymphomagenesis: EBV-Encoded MicroRNAs Expression in EBER-Negative Burkitt Lymphoma Cases Open
Epstein-Barr virus (EBV) is a gammaherpesvirus linked to a number of lymphoid and epithelial malignancies, including Burkitt lymphoma (BL) in which its frequency ranges from 30% in sporadic cases to 100% in the endemic ones. The possible c…
View article: SNPs Array Karyotyping in Non-Hodgkin Lymphoma
SNPs Array Karyotyping in Non-Hodgkin Lymphoma Open
The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent…
View article: Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation
Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation Open
View article: Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas Open
Burkitt lymphoma (BL) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. The latter is mostly driven by the MYC over-expression associated with the c…
View article: The presence of Epstein-Barr virus significantly impacts the transcriptional profile in immunodeficiency-associated Burkitt lymphoma
The presence of Epstein-Barr virus significantly impacts the transcriptional profile in immunodeficiency-associated Burkitt lymphoma Open
Burkitt lymphoma (BL) is an aggressive neoplasm derived from mature, antigen-experienced B-lymphocytes. Three clinical/epidemiological variants have been recognized, named sporadic, endemic and immunodeficiency-associated BL (ID-BL). Altho…
View article: Additional file 1: Table S1. of Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation
Additional file 1: Table S1. of Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation Open
List of inter and intra chromosomal gene fusion detected by fusion-detection pipeline. (XLS 89 kb)