Explanipedia

Cell therapy with placenta-derived mesenchymal stem cells for secondary progressive multiple sclerosis patients in a phase 1 clinical trial Open

Ameneh Shokati, Mohsen Nikbakht, Mohammad Ali Sahraian, Roghayyeh Saeedi, Elnaz Asadollahzadeh , et al. · 2025

Mesenchymal stem cell (MSC) has attracted significant attention in clinical research due to their immunomodulatory properties and potential to reduce inflammation in autoimmune disorders, such as multiple sclerosis (MS). This study evaluat…

Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant for leukocyte adhesion deficiency with graft failure: a case report Open

Azadeh Kiumarsi, Arash Alaei, Mohsen Nikbakht, Saeed Mohammadi, Mohammadreza Ostadali , et al. · 2025

Background With recent advances in clinical practice, including the use of reduced-toxicity conditioning regimens and innovative approaches such as ex vivo TCRαβ/CD19 depletion of haploidentical donor stem cells or post-transplant cyclopho…

Non-coding RNAs: Emerging contributors to chemoresistance in chronic myeloid leukemia Open

Laya Ghadyani Nejhad, Mahsa Sohani, Nasrin Alizad Ghandforoush, Mohsen Nikbakht, Saeed Mohammadi , et al. · 2025

Chronic myeloid leukemia (CML), is a myeloproliferative disease characterized by unregulated growth of blood forming cells in bone marrow and blood. The t(9;22)(q34;q11.2) translocation, which results in the formation of a hyperactive tyro…

Immune checkpoints and ncRNAs: pioneering immunotherapy approaches for hematological malignancies Open

Sara Anvari, Mohsen Nikbakht, Mohammad Vaezi, Sedigheh Amini‐Kafiabad, Mohammad Ahmadvand · 2024

The effect of Arsenic trioxide and its combination with Oxaliplatin and Docetaxel on the induction of autophagy and expression of LC3 and Beclin-1 genes in AGS and MKN-45 Gastric cancer cell lines Open

Shadi Babaei, Mohsen Nikbakht, Ahmad Majd, Seyed Asadoullah Mousavi · 2024

Purpose: Apoptosis and autophagy play critical roles in the survival and regulation of cancer cells, with key genes serving dual purposes in these processes. Arsenic trioxide (ATO), oxaliplatin (OXA), and docetaxel (DOC) are widely used in…

Combining Chemotherapy Agents and Autophagy Modulators for Enhanced Breast Cancer Cell Death Open

Soraya Moomivand, Mohsen Nikbakht, Ahmad Majd, Maryam Bikhof Torbati, Seyed Asadoullah Mousavi · 2024

Purpose: Autophagy, governed by genes with dual roles in cell death and survival, plays a crucial role in cancer persistence. Arsenic trioxide (ATO), carboplatin (CP), and cyclophosphamide (CY) are used to treat various cancers. ATO impede…

Graft failure after allogeneic hematopoietic stem cell transplantation in pediatric patients with acute leukemia: autologous reconstitution or second transplant? Open

Tahereh Rostami, Mohammad Reza Rostami, Amir Hossein Mirhosseini, Saeed Mohammadi, Mohsen Nikbakht , et al. · 2024

Background Graft failure (GF) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Prevention of graft failure remains the most advisable approach as there is no clear recommendation for the b…

Exploring the Potential of Montmorillonite as an Antiproliferative Nanoagent against MDA-MB-231 and MCF-7 Human Breast Cancer Cells Open

Alireza Ghannad Sabzevari, Hossein Sabahi, Mohsen Nikbakht, Mehdi Azizi, Hassan Dianat‐Moghadam , et al. · 2024

Unlike MCF-7 cells, MDA-MB-231 cells are unresponsive to hormone therapy and often show resistance to chemotherapy and radiotherapy. Here, the antiproliferative effect of biocompatible montmorillonite (Mt) nanosheets on MDA-MB-231 and MCF-…

Cytokine-Treated Natural Killer Cells Derived from Cord Blood Haematopoietic Stem Cells Exhibit Potential Cytotoxicity Against Cancer Cells Open

Fatemeh Hosseini, Mohammad Ahmadvand, Jafar Ai, Mohsen Nikbakht, Alireza Shokouhifar , et al. · 2024

Background: Despite substantial efforts to leverage natural killer (NK) cells in cancer immunotherapy, challenges associated with limited cell numbers and sources persist. In this study, our objective is to differentiate NK cells from cord…

Spotlight on the Expanding Role of DANCR in Tumorigenesis and Tumor Progression Open

Milad Rafat, Masoomeh Afsa, Mohsen Nikbakht, Kianoosh Malekzadeh · 2023

Context: Long non-coding RNA (lncRNA) is a novel set of non-coding RNAs (ncRNA), over 200 nucleotides in length, accounting for the regulation of genes and chromosome structure. There are a few articles, mostly focusing on changes in the e…

Osteoarthritis Treatment Based on Interventional Radiology, Using Umbilical Cord Mesenchymal Stem Cells Open

Maedeh Ruzbahani, Hossein Ghanaati, Ardeshir Ghavamzadeh, Ramin Sarrami‐Forooshani, Maryam Barkhordar , et al. · 2023

Introduction: Osteoarthritis is one of the most common joint diseases, which affects a large number of elderly people. No definite cure, except joint replacement (an invasive method) has not been known so far. We proposed a new way based o…

Experimental Investigation of Convective Heat Loss from a Cavity Receiver with Vertical Plate Fins Open

Hamideh Mobasheri‐Shiri, Tahereh Yazdanipour, Mohsen Nikbakht, Kiyanoosh Razzaghi · 2023

The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)? Open

Atousa Haghi, Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Reza Eghdami, Mohsen Nikbakht · 2022

Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autopha…

Anti‐inflammatory effect of mesenchymal stem cells on hepatocellular carcinoma in the xenograft mice model Open

Saieh Hajighasemlou, Mohsen Nikbakht, Saeedreza Pakzad, Abdolnaser Azadbakht, Samad Muhammadnejad , et al. · 2022

Background Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer and the second leading cause of cancer‐related deaths worldwide. Sorafenib is the standard treatment used in the advanced stages of HCC. Cell therapy with mesench…

Author response for "Anti‐inflammatory effect of mesenchymal stem cells on hepatocellular carcinoma in the xenograft mice model" Open

Saieh Hajighasemlou, Mohsen Nikbakht, Saeedreza Pakzad, Abdolnaser Azadbakht, Samad Muhammadnejad , et al. · 2022

A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis Open

Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi , et al. · 2021

The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major Open

Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi , et al. · 2021

The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Co-transplantation with Hematopoietic Stem Cells on Liver Fibrosis Alleviation and Survival in Patients with Class III β-thalassemia Major Open

Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi , et al. · 2021

Background: Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia major (BTM) patie…

Issue Information Open

Efstathios S. Gonos, Jiu‐Yao Wang, Ali Keshavarz, Atieh Pourbagheri‐Sigaroodi, Parisa Zafari , et al. · 2020

The Prognostic Impact of WT1 Expression Levels, Mutations, and SNP rs16754 in AML Patients: A Retrospective Cohort Study Open

Shahrbanoo Rostami, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht , et al. · 2020

Background and Objective: The clinical outcomes and treatment options for acute myeloid leukemia (AML) patients are highly dependent upon molecular markers. In this study, Wilms tumor (WT1) (exons 7 and 9) mutations, SNP …

Effects of different autophagy inhibitors on sensitizing KG‐1 and HL‐60 leukemia cells to chemotherapy Open

Atousa Haghi, Mahdieh Salemi, Aila Fakhimahmadi, Mahnaz Mohammadi Kian, Hassan Yousefi , et al. · 2020

A little number of current autophagy inhibitors may have beneficial effects on the acute myeloid leukemia (AML) patients. However, there is a strong need to figure out which settings should be activated or inhibited in autophagy pathway to…

Effects of Sorafenib and Arsenic Trioxide on U937 and KG-1 Cell Lines: Apoptosis or Autophagy? Open

Atousa Haghi, Mahdieh Salami, Mahnaz Mohammadi Kian, Mohsen Nikbakht, Saeed Mohammadi , et al. · 2020

The expression levels of apoptotic and autophagy activator genes were increased in response to treatment. The crosstalk between apoptosis and autophagy is a complicated mechanism and further investigations seem to be necessary.

Osteopontin siRNA does not confer resistance to toxic effects of parthenolide in Jurkat cells Open

Soghra Mehri, Saeed Mohammadi, Mohsen Nikbakht, Mehdi Sahmani, Mahdi Zahedpanah · 2020

Summary. Background: Osteopontin (OPN) plays a critical role in cell proliferation and drug resistance in cancer treatment and hematological malignancies. In T cell acute lymphoblastic leukemia, most initial therapies can induce remission …

Arsenic Trioxide and Thalidomide Combination Induces Autophagy Along with Apoptosis in Acute Myeloid Cell Lines. Open

Mahnaz Mohammadi Kian, Atousa Haghi, Mahdieh Salami, Bahram Chahardouli, Sara Rostami , et al. · 2020

Combined treatment with ATO and THAL can inhibit proliferation and invasion of AML cells by down-regulating ULK1 and BECLIN1 and up-regulating PTEN and IL6, and this effect was more marked than the effects of AT…

Indirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line. Open

Javid Sabour Takanlu, Arad Aghaie Fard, Saeed Mohammdi, Seyed Mohammad Ali Hosseini Rad, Saeid Abroun , et al. · 2020

It seems that assembling of H3K27me3 mark mediated by EZH2 is one of the key mechanisms of suppressing CDKN2A gene expression in MM disease. However, this suppressive function is applied by a multi-factor mechanism. In other words, …

Effects of different autophagy inhibitors on treatment with ATO/ATRA in KG-1 and HL-60 leukemia cells Open

Atousa Haghi, Mahdieh Salemi, Aila Fakhimahmadi, Mahnaz Mohammadikian, Hassan Yousefi , et al. · 2020

Background : Few current autophagy inhibitors may have beneficial effects for acute myeloid leukemia (AML) patients in clinical phases. However, there is a strong need to figure out which settings should be activated or inhibited in autoph…

A Single Center Study of Prescribing and Treatment Outcomes of Patients with Chronic Myeloid Leukemia Open

Ladan Nekoohesh, Mohammad H. Ghahremani, Shahrbano Rostami, Mohsen Nikbakht, Leila Nekoohesh , et al. · 2020

Background: The present study investigated the patients with Chronic Myeloid Leukemia in chronic phase (CP-CML) who had been on the first- line Imatinib Mesylate (IM) therapy for a period of 84 months. Materials and Methods: This retrospec…

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines Open

Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Bahadoran, Atousa Haghi, Nasrin Dashti , et al. · 2020

Overall, our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.

Sorafenib and Mesenchymal Stem Cell Therapy: A Promising Approach for Treatment of HCC Open

Saieh Hajighasemlou, Mohsen Nikbakht, Saeedreza Pakzad, Samad Muhammadnejad, Safoora Gharibzadeh , et al. · 2020

Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer and the second most common cause of cancer‐related death worldwide. Sorafenib (Sora) is used as a targeted therapy for HCC treatment. Mesenchymal stem cells (MSCs) …

Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines Open

Mohammadi Kian M, Marco Salemi, Mohammad Bahadoran, Atousa Haghi, Nasrin Dashti , et al. · 2020

Mahnaz Mohammadi Kian, 1, 2 Mahdieh Salemi, 1, 2 Mohammad Bahadoran, 3 Atousa Haghi, 1, 4 Nasrin Dashti, 5 Saeed Mohammadi, 1, 2 Shahrbano Rostami, 1, 2 Bahram Chahardouli, 1, 2 Davood Babakhani, 1 Mohsen Nikbakht 1, 2 1Hematology Oncology…

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