Moinuddin Moinuddin
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View article: Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications
Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications Open
Cell survival and death are intricately governed by apoptosis, a meticulously controlled programmed cell death. Apoptosis is vital in facilitating embryonic development and maintaining tissue homeostasis and immunological functioning. It i…
View article: A panoramic view of the strategies for epithelial ovarian cancer: a review of current challenges
A panoramic view of the strategies for epithelial ovarian cancer: a review of current challenges Open
Epithelial ovarian cancer (EOC) remains a formidable challenge in the field of gynecological oncology, accounting for a significant proportion of cancer-related deaths among women worldwide. Despite advances in surgical techniques and chem…
View article: Addressing the Global Challenge: Strategies for Cervical Prevention and Early Detection within WHO's 90-70-90 Framework
Addressing the Global Challenge: Strategies for Cervical Prevention and Early Detection within WHO's 90-70-90 Framework Open
Cervical cancer represents a substantial global health issue, standing as the third most prevalent cancer globally and the principal cause of cancer-associated mortality in women, with an uneven burden shouldered by less developed countrie…
View article: Proteomic Alterations and Metabolic Pathway Modulations Induced by Methyl Methane Sulfonate Treatment in Response to DNA Damage
Proteomic Alterations and Metabolic Pathway Modulations Induced by Methyl Methane Sulfonate Treatment in Response to DNA Damage Open
Exposure to methyl methane sulfonate (MMS), an alkylating agent, induces DNA damage, increasing cellular and metabolic sensitivity, leading to cellular demise and a delay in the cell cycle. This delay is attributed to changes in global tra…
View article: Influence of foliar applications with organic sources of nutrients on growth and yield of soybean (Glycin max L.) A research review
Influence of foliar applications with organic sources of nutrients on growth and yield of soybean (Glycin max L.) A research review Open
Soybean (Glycine max L.) is an economically important crop globally, valued for its high protein content and versatile applications in food, feed, and industrial products. In recent years, there has been a growing interest in organic farmi…
View article: Glycoxidation of mammalian whole histone generates highly immunogenic aggregates: Sera of SLE patients contain autoantibodies against aggregates
Glycoxidation of mammalian whole histone generates highly immunogenic aggregates: Sera of SLE patients contain autoantibodies against aggregates Open
Non‐enzymatic glycation and oxidation of self‐proteins, causing formation and accumulation of advanced glycation end products (AGEs), have been reported in an array of pathologies, including systemic lupus erythematosus (SLE). Such modific…
View article: Effect of Bio fertilizers with NPK Level on Vegetative Growth, Flowering and Flower Yield of F1 Hybrid (Pusa Basanti) of african marigold
Effect of Bio fertilizers with NPK Level on Vegetative Growth, Flowering and Flower Yield of F1 Hybrid (Pusa Basanti) of african marigold Open
An investigation was carried out to study effect of Biofertilizers with NPK levels on vegetative growth, flowering and flower yield of F1 hybrid ( Pusa Basanti) of African marigold (Targets erecta ) during the winter season 2008-2009 .The …
View article: NAVIGATING THE PEDAGOGICAL LANDSCAPE: STATISTICAL ANALYSIS OF TEACHING STRATEGIES IN ENGLISH LANGUAGE EDUCATION
NAVIGATING THE PEDAGOGICAL LANDSCAPE: STATISTICAL ANALYSIS OF TEACHING STRATEGIES IN ENGLISH LANGUAGE EDUCATION Open
Background: This study dives into the pedagogical approaches used by English teachers, with the goal of revealing widespread teaching strategies in this setting. Objectives: The primary goal is to identify typical teaching approaches and i…
View article: Evaluation of Oral Bioavailability and In-vivo Anti-leukemic Potential of Dasatinib Loaded Solid Lipid Nanoparticles
Evaluation of Oral Bioavailability and In-vivo Anti-leukemic Potential of Dasatinib Loaded Solid Lipid Nanoparticles Open
Dasatinib is one of the second-generation tyrosine kinase inhibitors (TKI) that is taken orally and has antiproliferative activity against chronic myeloid leukemia (CML). Dasatinib/hesperidin loaded-SLNs were synthesized in-house using a h…
View article: Dasatinib and Hesperidin Loaded Nano Formulation and Preclinical Evaluation for Anticancer Activity
Dasatinib and Hesperidin Loaded Nano Formulation and Preclinical Evaluation for Anticancer Activity Open
In this study, we aimed to develop Dasatinib/hesperidin-loaded-SLNs for chronic myeloid leukemia (CML). Utilizing a high-shear homogenizer for the synthesis, “central composite design (CCD)” was used to enhance the dasatinib/hesperidin loa…
View article: Effect Of Organic Manure With Beejamrit Inoculation On Growth And Yield Parameters Of Summer Moongbean (Vignaradiatal.).
Effect Of Organic Manure With Beejamrit Inoculation On Growth And Yield Parameters Of Summer Moongbean (Vignaradiatal.). Open
A field experiment was carried out at Shri Guru Ram Rai University,Pathri Bagh Dehradun during the summer of 2022, 2023 and pooled with the goal of evaluating the Effect of organic manures with beejamrit inoculation on growth and yield par…
View article: 4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin
4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin Open
4-Chloro-1,2-phenylenediamine (4-Cl-OPD) is a halogenated aromatic diamine used as a precursor in permanent hair color production. Despite its well-documented mutagenic and carcinogenic effects in various in vitro and in vivo models, its r…
View article: Effects of Intercropping on Plant Growth and Yield Performance of Toria (Brassica campestris L.) and Field Pea (Pisum sativum L.) under Irrigated Conditions
Effects of Intercropping on Plant Growth and Yield Performance of Toria (Brassica campestris L.) and Field Pea (Pisum sativum L.) under Irrigated Conditions Open
Background: Intercropping with legumes improves resource use efficiency, soil N, soil quality, yields and profitability. Having deep root system, legumes can extract moisture and nutrients from deeper layer and hence does not compete with …
View article: Effects of Foliar Application of Melatonin on Head Yield and Quality of Broccoli cv. Palam Samridhi
Effects of Foliar Application of Melatonin on Head Yield and Quality of Broccoli cv. Palam Samridhi Open
Background: Broccoli is a cruciferous vegetable with green flower buds. It has a reputation as a superfood as it is low in calories but contains a wealth of nutrients and antioxidants that support many aspects of human health. Broccoli is …
View article: Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress Open
The micro- and macro-complications in diabetes mellitus (DM) mainly arise from the damage induced by Amadori and advanced glycation end products, as well as the released free radicals. The primary goal of DM treatment is to reduce the risk…
View article: Effects of foliar application of melatonin on gas exchange and certain biochemical characteristics broccoli cv. Palam Samridhi
Effects of foliar application of melatonin on gas exchange and certain biochemical characteristics broccoli cv. Palam Samridhi Open
Considering the rich nutritional status and possibility of broccoli in improving the profitable yield, and wide role of Mel in regulating the plant physiological process, an investigation was carried out at the division of Basic Sciences a…
View article: A divide and conquer approach for large spatial dataset
A divide and conquer approach for large spatial dataset Open
In recent times, the rise of `big data' has brought along major computational challenges in all the main disciplines of scientific research, including the field of spatial statistics. Some of these challenges include parametric estimation …
View article: Molecular docking explores heightened immunogenicity and structural dynamics of acetaldehyde human immunoglobulin G adduct
Molecular docking explores heightened immunogenicity and structural dynamics of acetaldehyde human immunoglobulin G adduct Open
Acetaldehyde is a metabolite of ethanol, an important constituent of tobacco pyrolysis and the aldehydic product of lipid peroxidation. Acetaldehyde induced toxicity is mainly due to its binding to cellular macromolecules resulting in the …
View article: A study on hepatopathic, dyslipidemic and immunogenic properties of fructosylated-HSA-AGE and binding of autoantibodies in sera of obese and overweight patients with fructosylated-HSA-AGE
A study on hepatopathic, dyslipidemic and immunogenic properties of fructosylated-HSA-AGE and binding of autoantibodies in sera of obese and overweight patients with fructosylated-HSA-AGE Open
Over consumption of fructose may lead to obesity and dyslipidemia and cause fructosylation-induced alterations in the structure and function of proteins. The aim of this study was to investigate the role of fructosylated-HSA-AGE in the pat…
View article: A research review on the use of different organic sources of nitrogen in groundnut (Arachis hypogaea L.)
A research review on the use of different organic sources of nitrogen in groundnut (Arachis hypogaea L.) Open
Groundnut is the single largest source of edible oils in India and constitutes roughly about 50% of the total oilseeds production. Currently, India grows about more than 8 million tonnes of groundnut (in the shell). Use of organic manures …
View article: Methylglyoxal produces more changes in biochemical and biophysical properties of human IgG under high glucose compared to normal glucose level
Methylglyoxal produces more changes in biochemical and biophysical properties of human IgG under high glucose compared to normal glucose level Open
Hyperglycaemia triggers increased production of methylglyoxal which can cause gross modification in proteins' structure vis-a-vis function though advanced glycation end products (AGEs). The AGEs may initiate vascular and nonvascular pathol…
View article: Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer Open
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced gly…
View article: Immuno‐chemistry of hydroxyl radical modified <scp>GAD</scp>‐65: A possible role in experimental and human diabetes mellitus
Immuno‐chemistry of hydroxyl radical modified <span>GAD</span>‐65: A possible role in experimental and human diabetes mellitus Open
The repertoire of known auto‐antigens is limited to a very small proportion of all human proteins, and the reason why only some proteins become auto‐antigens is unclear. The 65 kDa isoform of the enzyme glutamic acid decarboxylase (GAD‐65)…
View article: Fructosylation generates neo‐epitopes on human serum albumin
Fructosylation generates neo‐epitopes on human serum albumin Open
Hyperglycemia is the defining feature of diabetes mellitus. The persistently high levels of reducing sugars like glucose and fructose cause glycation of various macromolecules in the body. Human serum albumin (HSA), the most abundant serum…