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View article: The influence of APOEε4 on cognition in Hispanics: The Panama Aging Research Initiative ‐ Health Disparities Study
The influence of APOEε4 on cognition in Hispanics: The Panama Aging Research Initiative ‐ Health Disparities Study Open
Background The apolipoprotein E (APOE) gene is a well‐established risk factor for Alzheimer's disease. This study aims to investigate the relationship between APOE genotype and cognitive aging in a sample of Hispanics. We also present data…
View article: The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins Open
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023–2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen. To determine the durability and breadth of the antibody re…
View article: Prospective cohort study to evaluate the diagnostic values of biomarkers in blood, cerebrospinal fluid and magnetic resonance imaging for mild cognitive impairment, Alzheimer's disease and Parkinson's disease in Hispanics
Prospective cohort study to evaluate the diagnostic values of biomarkers in blood, cerebrospinal fluid and magnetic resonance imaging for mild cognitive impairment, Alzheimer's disease and Parkinson's disease in Hispanics Open
Background By 2025, an estimated three‐quarters of the global population aged 60 and older will live in Latin American and Caribbean countries (LAC), leading to a rise in age‐related conditions. The main goal of the Panama Aging Research I…
View article: Spatial and temporal variation in respiratory syncytial virus (RSV) subtype RNA in wastewater and relation to clinical specimens
Spatial and temporal variation in respiratory syncytial virus (RSV) subtype RNA in wastewater and relation to clinical specimens Open
Respiratory syncytial virus (RSV) causes a large burden of respiratory illness globally. It has two subtypes, RSV A and RSV B, but little is known regarding the predominance of these subtypes during different seasons and their impact on mo…
View article: Spatial and temporal variation in respiratory syncytial virus (RSV) subtype RNA in wastewater, and relation to clinical specimens
Spatial and temporal variation in respiratory syncytial virus (RSV) subtype RNA in wastewater, and relation to clinical specimens Open
Respiratory syncytial virus (RSV) causes a large burden of respiratory illness, globally. It has two subtypes, RSV A and RSV B, but little is known regarding the predominance of these subtypes during different seasons and their impact on m…
View article: Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster
Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster Open
To determine the neutralization efficiency of the booster vaccines against wild-type (WA1/2020) virus and primary isolates of omicron subvariants BA.1, BA.5, BA.2.75.2, BQ.1.1, and XBB.
View article: mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1
mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1 Open
The emergence of the highly divergent SARS-CoV-2 Omicron variant has jeopardized the efficacy of vaccines based on the ancestral spike. The bivalent COVID-19 mRNA booster vaccine within the United States is comprised of the ancestral and t…
View article: An 8-gene machine learning model improves clinical prediction of severe dengue progression
An 8-gene machine learning model improves clinical prediction of severe dengue progression Open
Background Each year 3–6 million people develop life-threatening severe dengue (SD). Clinical warning signs for SD manifest late in the disease course and are nonspecific, leading to missed cases and excess hospital burden. Better SD progn…
View article: From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB) [Corrigendum]
From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB) [Corrigendum] Open
[This corrects the article DOI: 10.2147/CCID.S232547.].
View article: <p>From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB)</p>
From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB) Open
We conclude that genetic allele frequency estimation may enhance the underdiagnosis of rare genetic diseases generally, and RDEB specifically, which may improve incidence and prevalence estimates of patients who may benefit from treatment.
View article: Phase 2 trial of a neurokinin-1 receptor antagonist for the treatment of chronic itch in patients with epidermolysis bullosa: A randomized clinical trial
Phase 2 trial of a neurokinin-1 receptor antagonist for the treatment of chronic itch in patients with epidermolysis bullosa: A randomized clinical trial Open
The potential itch reduction with serlopitant observed in this trial will be pursued by a larger powered trial (NCT03836001).