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View article: Assessment of Sedation in Mechanically Ventilated Children with Severe Acute Bronchiolitis: Correlation Between COMFORT-B Scale and Bispectral Index During Continuous Infusion of Fentanyl and Midazolam
Assessment of Sedation in Mechanically Ventilated Children with Severe Acute Bronchiolitis: Correlation Between COMFORT-B Scale and Bispectral Index During Continuous Infusion of Fentanyl and Midazolam Open
Background and Objectives: Analgesia and sedation are a major challenge in pediatric intensive care. The COMFORT-B scale and the Bispectral Index (BIS) are commonly used to assess the degree of sedation. The aim of this study was to invest…
View article: Pharmacist-led hospital intervention reduces unintentional patient-generated medication discrepancies after hospital discharge
Pharmacist-led hospital intervention reduces unintentional patient-generated medication discrepancies after hospital discharge Open
Background Medication reconciliation can significantly reduce clinically important medication errors at hospital discharge, but its impact on post-discharge medication management has not been investigated. We aimed to investigate the incid…
View article: Impact of changes in antihypertensive medication on treatment intensity at hospital discharge and 30 days afterwards
Impact of changes in antihypertensive medication on treatment intensity at hospital discharge and 30 days afterwards Open
Introduction Little is known about the cumulative effect of changes in antihypertensive medications on treatment intensity. This study analyzed how changes in antihypertensive medications affect the intensity of antihypertensive treatment …
View article: Population pharmacokinetics of ramipril in patients with chronic heart failure: A real-world longitudinal study
Population pharmacokinetics of ramipril in patients with chronic heart failure: A real-world longitudinal study Open
In patients with chronic heart failure (CHF), the use of angiotensin-converting enzyme inhibitors, including ramipril, is recommended to reduce the risk of heart failure worsening, hospitalisation, and death. Our aim was to investigate the…
View article: Effectiveness of pharmacist-led medication reconciliation on medication errors at hospital discharge and healthcare utilization in the next 30 days: a pragmatic clinical trial
Effectiveness of pharmacist-led medication reconciliation on medication errors at hospital discharge and healthcare utilization in the next 30 days: a pragmatic clinical trial Open
Transitions of care often lead to medication errors and unnecessary healthcare utilization. Medication reconciliation has been repeatedly shown to reduce this risk. However, the great majority of evidence is limited to the provision of med…
View article: Sex-Dependent Differences in Blood–Urine Barrier Are Subtle but Significant in Healthy and Chronically Inflamed Mouse Bladders
Sex-Dependent Differences in Blood–Urine Barrier Are Subtle but Significant in Healthy and Chronically Inflamed Mouse Bladders Open
The urothelium is a vital permeability barrier that prevents the uncontrolled flow of urinary components into and out of the bladder interstitium. Our study addressed the question of possible sex-specific variations in the urothelium of he…
View article: Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions
Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions Open
A non-interventional retrospective study in ambulatory patients was conducted at the emergency department of the Division of internal medicine. In 2 months, 266 suspected adverse drug reactions (ADRs) were identified in 224/3453 patients (…
View article: External validation of population pharmacokinetic models of gentamicin in paediatric population from preterm newborns to adolescents
External validation of population pharmacokinetic models of gentamicin in paediatric population from preterm newborns to adolescents Open
The aim of this study was to externally validate the predictive performance of published population pharmacokinetic models of gentamicin in all paediatric age groups, from preterm newborns to adolescents. We first selected published popula…
View article: Abstracts 8th PCNE working symposium ‘Navigating research on pharmaceutical care’. 11–12 February 2022, Lisbon, Portugal
Abstracts 8th PCNE working symposium ‘Navigating research on pharmaceutical care’. 11–12 February 2022, Lisbon, Portugal Open
Following amendment of German legislation in 2020, patients are entitled to pharmaceutical care services including medication reviews (MRs). Despite this, provision of such services is not mandatory for community pharmacies and MRs are not…
View article: Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice?
Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice? Open
The aging of organisms leads to a decreased ability of tissue to regenerate after injury. The regeneration of the bladder urothelium after induced desquamation with biopolymer chitosan has been studied in young mice but not in old mice. Ch…
View article: Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium
Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium Open
Induced desquamation of urinary bladder epithelial cells, also called urothelial cells, is frequently used in studies of bladder epithelial regeneration and also in treating recurrent bacterial cystitis. Positively charged polymer chitosan…
View article: A review of population pharmacokinetic models of gentamicin in paediatric patients
A review of population pharmacokinetic models of gentamicin in paediatric patients Open
Based on our review, the authors agree on a prolonged dosing interval for preterm and term newborns (up to 48 hours). However, there was no agreement on proposed dosing with respect to gestational age. In general, the proposed daily doses …
View article: Repeated treatments with chitosan in combination with antibiotics completely eradicate uropathogenic <i>Escherichia coli</i> from infected mouse urinary bladders
Repeated treatments with chitosan in combination with antibiotics completely eradicate uropathogenic <i>Escherichia coli</i> from infected mouse urinary bladders Open
Uropathogenic Escherichia coli (UPEC), the primary causative agents of urinary tract infections, colonize and invade the epithelial cells of the bladder urothelium. Infection of immature urothelial cells can result in the formation of pers…
View article: Bisoprolol pharmacokinetics and body composition in patients with chronic heart failure: a longitudinal study
Bisoprolol pharmacokinetics and body composition in patients with chronic heart failure: a longitudinal study Open
In patients with chronic heart failure, bisoprolol clearance was associated with estimated renal function; thus, in moderately and severely decreased renal function, patients may need to have their dose adjusted. Patients with low body wei…