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View article: Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes
Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes Open
In recent years, biopharmaceutical purification processes have shifted towards more productive and cost-effective methods. Membrane technology has emerged as viable alternative to conventional resins, capable of delivering similar product …
View article: Lactococcus lactis as a delivery system for surface displayed mimotopes of major peanut allergen Ara h 2
Lactococcus lactis as a delivery system for surface displayed mimotopes of major peanut allergen Ara h 2 Open
The prevalence of peanut allergy has been steadily increasing over the last decades. Among food allergies it shows the highest severity and is potentially fatal. Allergen Ara h 2 stands out as the main elicitor of allergic reactions. Resea…
View article: Efficient Host Cell Protein Clearance: A Study of Membrane Adsorbers and Resins in Biopharmaceutical Processes
Efficient Host Cell Protein Clearance: A Study of Membrane Adsorbers and Resins in Biopharmaceutical Processes Open
View article: Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-Degrading Host Cell Protein in a Monoclonal Antibody Formulation Using Activity-Based Protein Profiling
Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-Degrading Host Cell Protein in a Monoclonal Antibody Formulation Using Activity-Based Protein Profiling Open
Polysorbate (PS) degradation in monoclonal antibody (mAb) formulations poses a significant challenge in the biopharmaceutical industry. PS maintains protein stability during drug product's shelf life but is vulnerable to breakdown by low-a…
View article: Featured Cover
Featured Cover Open
The cover image is based on the Original Article Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation by Peter Korošec et al., https://doi.org/10.1111/cea.1431…
View article: Featured Cover
Featured Cover Open
The cover image is based on the Original Article Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation by Peter Korošec et al., https://doi.org/10.1111/cea.1431…
View article: Ara h 2‐specific IgE epitope‐like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE‐dependent effector cell activation
Ara h 2‐specific IgE epitope‐like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE‐dependent effector cell activation Open
Background Clinical and experimental analyses indicate a pathognomonic role for allergen IgE crosslinking through epitope–paratope interactions as a major initial step in the cascade leading to effector cell activation and clinical manifes…
View article: Combination of Experimental and Bioinformatic Approaches for Identification of Immunologically Relevant Protein–Peptide Interactions
Combination of Experimental and Bioinformatic Approaches for Identification of Immunologically Relevant Protein–Peptide Interactions Open
Protein–peptide interactions are an essential player in cellular processes and, thus, of great interest as potential therapeutic agents. However, identifying the protein’s interacting surface has been shown to be a challenging task. Here, …
View article: Epitope Mapping of Major Ragweed Allergen Amb a 1
Epitope Mapping of Major Ragweed Allergen Amb a 1 Open
Ragweed is a prominent cause of seasonal allergies. Thus far, information on IgE-binding sites of major allergen in ragweed pollen, Amb a 1, is very limited. A powerful experimental method to gain insights on the allergen epitopes is the s…
View article: Microbial Delivery Vehicles for Allergens and Allergen-Derived Peptides in Immunotherapy of Allergic Diseases
Microbial Delivery Vehicles for Allergens and Allergen-Derived Peptides in Immunotherapy of Allergic Diseases Open
Allergen-specific immunotherapy represents the only available curative approach to allergic diseases. The treatment has proven effective, but it requires repetitive administrations of allergen extracts over 3-5 years and is often associate…
View article: Cardioprotective effects of silver fir (<i>Abies alba</i>) extract in ischemic-reperfused isolated rat hearts
Cardioprotective effects of silver fir (<i>Abies alba</i>) extract in ischemic-reperfused isolated rat hearts Open
We conclude that the SFTE exerted the strongest cardioprotective effect, whereas its constituents (the p-coumaric and protocatechuic acids) were less effective in inducing cardioprotection.
View article: Cross-affinity of peptide ligands selected from phage display library against pancreatic phospholipase A2 and ammodytoxin C
Cross-affinity of peptide ligands selected from phage display library against pancreatic phospholipase A2 and ammodytoxin C Open
Two phage-displayed random peptide libraries were screened for ligands with potential inhibitory activity against pancreatic phospolipase A2 or ammodytoxin C (neurotoxin found in the venom glands of Vipera ammodytes ammodytes). The interac…
View article: Affinity ranking of phage-displayed peptides: enzyme-linked immunosorbent assay versus surface plasmon resonance
Affinity ranking of phage-displayed peptides: enzyme-linked immunosorbent assay versus surface plasmon resonance Open
Peptides with particular affinity and specificity for variety of targets are selected through panning procedure from random peptide phage display libraries. Efficiency and convenience of enzyme linked immunosorbent assay (ELISA) and surfac…
View article: Peptide modulators of alpha‐glucosidase
Peptide modulators of alpha‐glucosidase Open
Aims/Introduction Acute glucose fluctuations during the postprandial period pose great risk for cardiovascular complications and thus represent an important therapeutic approach in type 2 diabetes. In the present study, screening of peptid…