Mojgan Mokhtari
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View article: Collagen disorder architecture features are associated with clinical, molecular, genetic factors and survival outcomes in colon cancer
Collagen disorder architecture features are associated with clinical, molecular, genetic factors and survival outcomes in colon cancer Open
We developed a computational pathology pipeline to extract and analyze collagen disorder architecture (CoDA) features from whole slide images (WSIs) of 2,212 colon cancer (CC) patients across multiple institutions. CoDA features-capturing …
View article: Sexually dimorphic computational histopathological signatures prognostic of overall survival in high-grade gliomas via deep learning
Sexually dimorphic computational histopathological signatures prognostic of overall survival in high-grade gliomas via deep learning Open
High-grade glioma (HGG) is an aggressive brain tumor. Sex is an important factor that differentially affects survival outcomes in HGG. We used an end-to-end deep learning approach on hematoxylin and eosin (H&E) scans to (i) identify sex-sp…
View article: Computational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies
Computational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies Open
Background The role of immune cells in collagen degradation within the tumor microenvironment (TME) is unclear. Immune cells, particularly tumor-infiltrating lymphocytes (TILs), are known to alter the extracellular matrix, affecting cancer…
View article: Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer
Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer Open
View article: Evaluation of nestin expression in melanoma, basal cell carcinoma and basosquamous carcinoma
Evaluation of nestin expression in melanoma, basal cell carcinoma and basosquamous carcinoma Open
Introduction: Nestin plays a significant role in diagnosis, prognosis, clinical course and/or response to the treatment. Previous studies have investigated the nestin expression in melanoma, however a limited number have focused on basal c…
View article: 61 Combination of novel biomarkers of collagen fiber and immune architecture are associated with clinically relevant outcomes in gynecological cancers treated with immunotherapy
61 Combination of novel biomarkers of collagen fiber and immune architecture are associated with clinically relevant outcomes in gynecological cancers treated with immunotherapy Open
Background Qualitative studies suggest collagen fiber organization (CFO) is associated with gynecological cancer (GC) prognosis.1, 2 Previous studies have shown the prognostic role of quantitative characterization of architectur…
View article: Improving the Diagnosis of Skin Biopsies Using Tissue Segmentation
Improving the Diagnosis of Skin Biopsies Using Tissue Segmentation Open
Invasive melanoma, a common type of skin cancer, is considered one of the deadliest. Pathologists routinely evaluate melanocytic lesions to determine the amount of atypia, and if the lesion represents an invasive melanoma, its stage. Howev…
View article: Segmenting Skin Biopsy Images with Coarse and Sparse Annotations using U-Net
Segmenting Skin Biopsy Images with Coarse and Sparse Annotations using U-Net Open
View article: Phaeohyphomycosis in a COVID-19 Patient Caused by Neoscytalidium Dimidiatum
Phaeohyphomycosis in a COVID-19 Patient Caused by Neoscytalidium Dimidiatum Open
We report a case of 32-years-old male with a cerebral phaeohyphomycosis post COVID-19 infection from Iran. The causative agent was identified by histopathology, routine mycological methods and confirmed by DNA sequencing of the internal tr…
View article: Prediction of Intraperitoneal Adhesions in Repeated Cesarean Section Using Sliding Sign, Striae Gravidarum, and Cesarean Scar
Prediction of Intraperitoneal Adhesions in Repeated Cesarean Section Using Sliding Sign, Striae Gravidarum, and Cesarean Scar Open
Background: Intraabdominal adhesions are associated with an increase in complications during cesarean section because of recurrent cesarean sections. This is why the possibility of predicting adhesions is important. In this study, t…
View article: Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities
Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities Open
Background We present a computational approach (ArcTIL) for quantitative characterization of the architecture of tumor-infiltrating lymphocytes (TILs) and their interplay with cancer cells from digitized H&E-stained histology whole slide i…
View article: An Imaging Biomarker of Tumor-Infiltrating Lymphocytes to Risk-Stratify Patients With HPV-Associated Oropharyngeal Cancer
An Imaging Biomarker of Tumor-Infiltrating Lymphocytes to Risk-Stratify Patients With HPV-Associated Oropharyngeal Cancer Open
Background Human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) has excellent control rates compared to nonvirally associated OPSCC. Multiple trials are actively testing whether de-escalation of treatment int…
View article: NIMG-60. PREDICTING OVERALL SURVIVAL IN GLIOBLASTOMA USING HISTOPATHOLOGY VIA AN END-TO-END DEEP LEARNING PIPELINE: A LARGE MULTI-COHORT STUDY
NIMG-60. PREDICTING OVERALL SURVIVAL IN GLIOBLASTOMA USING HISTOPATHOLOGY VIA AN END-TO-END DEEP LEARNING PIPELINE: A LARGE MULTI-COHORT STUDY Open
PURPOSE Glioblastoma is an aggressive and universally fatal tumor. Morphological information as captured from cellular regions on surgically resected histopathology slides has the ability to reveal the inherent heterogeneity in Glioblastom…
View article: Investigation of microRNA-10b values for the discrimination of metastasis due to melanoma
Investigation of microRNA-10b values for the discrimination of metastasis due to melanoma Open
Background: Melanoma is one of the most invasive cutaneous cancers with characteristics such as rapid progression and distant metastasis. The early diagnosis and staging of melanoma can help better manage the patients. The current study is…
View article: Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study
Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study Open
Objective: Uterine leiomyoma (UL) can be considered as the most common benign gynecological tumors of the smooth muscle cells in the myometrium. They are likely to be associated with infertility and recurrent abortion as well as obstructed…
View article: Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients.
Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients. Open
The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100…
View article: Association of HOTAIR gene polymorphisms and haplotypes with uterine leiomyoma susceptibility in southeast of Iran
Association of HOTAIR gene polymorphisms and haplotypes with uterine leiomyoma susceptibility in southeast of Iran Open
View article: Comparison of the Frequency Asymptomatic Bacteriuria in Patients with Preterm Labor and Term
Comparison of the Frequency Asymptomatic Bacteriuria in Patients with Preterm Labor and Term Open
Background: Asymptomatic bacteriuria is prevalent in pregnancy and has unpleasant side effects such as hypertension, preeclampsia, Intra uterine growth restriction, preterm labor, low birth weight, postpartum endometritis, pyelonephritis, …
View article: The ‑2549 insertion/deletion polymorphism in the promoter region of VEGF is associated with the risk of recurrent spontaneous abortion
The ‑2549 insertion/deletion polymorphism in the promoter region of VEGF is associated with the risk of recurrent spontaneous abortion Open
Recurrent spontaneous abortion (RSA) is a common health problem affecting women of reproductive age. Altered expression of vascular endothelial growth factor (VEGF) has been associated with spontaneous abortion. The present case-con…
View article: Association between oral lichen planus and Epstein–Barr virus in Iranian patients
Association between oral lichen planus and Epstein–Barr virus in Iranian patients Open
Results emphasized that EBV genome was significantly higher among Iranian patients with OLP so antiviral therapy might be helpful.
View article: Evaluation of HLA-G 14-bp ins/del and +3142G>C polymorphisms with susceptibility to recurrent spontaneous abortion
Evaluation of HLA-G 14-bp ins/del and +3142G>C polymorphisms with susceptibility to recurrent spontaneous abortion Open
View article: Expression of Epstein-Barr virus nuclear antigen (EBNA) in papillary thyroid carcinoma in a population of patients in Isfahan city, Iran.
Expression of Epstein-Barr virus nuclear antigen (EBNA) in papillary thyroid carcinoma in a population of patients in Isfahan city, Iran. Open
View article: The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes
The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes Open
Background: Hepatitis C infection is one of the health problems in the world. Several known risk factors are responsible in transmission of this infection. We are going to study the prevalence of these risk factors for different genotypes …
View article: Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis
Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis Open
Uterine leiomyoma (UL) is the most common benign tumor causing considerable morbidity during the reproductive years in women. Cyclin D1 (CCND1) is a cell cycle regulatory protein that is required for the G1 phase, and increased expression …
View article: Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population.
Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population. Open
The FAS polymorphism was associated with the risk of UL in a sample of Iranian women.
View article: Effect of 12 weeks aerobic exercises on levels of Vaspin and Nesfatin -1 plasma in hypertensive elderly women
Effect of 12 weeks aerobic exercises on levels of Vaspin and Nesfatin -1 plasma in hypertensive elderly women Open
Background: Adipokines such as Vaspin and Nesfatin have different biological roles and may be in relation to cardiovascular and hypertension related diseases. Objective: To investigate the effects of 12 weeks aerobic exercises on plasma le…
View article: بررسی ویروس Epstein–Barr در کارسینوم پستان در جمعیتی از زنان ایرانی
بررسی ویروس Epstein–Barr در کارسینوم پستان در جمعیتی از زنان ایرانی Open
مقدمه: کارسینوم پستان، یکی از شایعترین سرطانها در میان زنان به شمار میرود که در میان انواع آن، کارسینوم داکتال مهاجم پستان، شایعترین نوع کارسینوم پستان میباشد. ویروس Epstein–Barr، مظنون اصلی در ارتباط با اتیولوژی ویروسی این سرطان است.…
View article: MONOCLONAL ANTIBODY HBME-1 USEFULNESS IN DIFFERENTIATION OF BENIGN NEOPLASM AND DIFFERENTIATED THYROID CARCINOMA
MONOCLONAL ANTIBODY HBME-1 USEFULNESS IN DIFFERENTIATION OF BENIGN NEOPLASM AND DIFFERENTIATED THYROID CARCINOMA Open
- HBME-l is an antimesothelial monoclonal antibody that recognizes an unknown antigen on microvilli of mesothelial cells. The antibody is only relatively specific for mesothelium and is used in the differential diagnosis of mesothelioma an…
View article: Does working in hospital increases seroprevalence and carrier state against Bordetella pertussis?
Does working in hospital increases seroprevalence and carrier state against Bordetella pertussis? Open
This study showed that majority of cases do not have protective serum antibody against B. pertussis. Working in hospitals does not affect seroprevalence and carrier state of B. pertussis. Immunization schedules that include no booster dose…
View article: Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases?
Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases? Open
The change in the percentages of the peripheral blood T cells expressing the γδTCR and αβTCR in the celiac patients could be used in conjunction with the other serological markers to identify new CD cases.