Mojtaba Fathi
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View article: Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study
Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study Open
Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export pump (BSEP…
View article: Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub- Types of GERD
Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub- Types of GERD Open
View article: Nigeria’s 6-year (2018–2023) stage distribution of breast cancer at diagnosis: a systematic review and meta-analysis
Nigeria’s 6-year (2018–2023) stage distribution of breast cancer at diagnosis: a systematic review and meta-analysis Open
Advanced-stage BC remains prevalent in Nigeria. A comprehensive evaluation of current BC control strategies is needed to identify barriers and develop effective interventions for early diagnosis and treatment.
View article: Study of the Association Between MTHFR Polymorphism (rs1801133) and the Outcome of Methotrexate Treatment in Rheumatoid Arthritis Patients
Study of the Association Between MTHFR Polymorphism (rs1801133) and the Outcome of Methotrexate Treatment in Rheumatoid Arthritis Patients Open
View article: Effect of aminoguanidine on plasminogen activator inhibitor-1 and receptor of advanced glycation endproduct in the liver of streptozotocin-induced diabetic rats
Effect of aminoguanidine on plasminogen activator inhibitor-1 and receptor of advanced glycation endproduct in the liver of streptozotocin-induced diabetic rats Open
Objectives: Advanced glycation end products (AGEs) play an important role in the development and progression of diabetic complications. The receptor for AGE (RAGE) is the ligand-binding site of AGE that initiates and accelerates the athero…
View article: Evaluation of the relationship between ABCB11 gene polymorphism and the incidence of gallstones and related SGOT and SGPT biochemical factors in the Iranian population
Evaluation of the relationship between ABCB11 gene polymorphism and the incidence of gallstones and related SGOT and SGPT biochemical factors in the Iranian population Open
Evaluation of the relationship between ABCB11 gene polymorphism and the incidence of gallstones and related SGOT and SGPT biochemical factors in the Iranian population
View article: Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells
Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells Open
Background Colorectal cancer (CRC) is the second leading cause of cancer death. Although Regorafenib showed survival benefits in patients with CRC, reports imply the recurrence of malignant phenotype resulting from chemotherapy. Evidence d…
View article: The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial
The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial Open
View article: Decreased Interleukin 6 and Tumor Necrosis Factor α Proteins and Metalloproteinase-2,9 Levels Following Cerebral Ischemia in Cinnamon-treated Rats
Decreased Interleukin 6 and Tumor Necrosis Factor α Proteins and Metalloproteinase-2,9 Levels Following Cerebral Ischemia in Cinnamon-treated Rats Open
Background: Metabolic disturbances, including hyperlipidaemia, are risk factors for brain ischemia. Despite all research, no definitive treatment has yet been found for brain ischemia. Thus, this study investigated the effect of cinnamon o…
View article: Advanced Glycation End Product Blocker Drugs Have a Great Potential to Prevent Diabetic Cardiomyopathy in an Animal Model of Diabetes Mellitus Type-2
Advanced Glycation End Product Blocker Drugs Have a Great Potential to Prevent Diabetic Cardiomyopathy in an Animal Model of Diabetes Mellitus Type-2 Open
Introduction. Sphingosine 1 phosphate (S1P) is a product of the sphingosine kinase 1 (SphK1) enzyme. Increased S1P can lead to tissue fibrosis that is also one of the pathways for developing diabetic cardiomyopathy. Advanced glycation end …
View article: Additional file 2 of The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial
Additional file 2 of The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial Open
Additional file 2: The Flow Cytometric assay results of per-patient levels of platelet CD62P Ag expression at baseline (B) and week 26 (A).
View article: Additional file 1 of The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial
Additional file 1 of The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial Open
Additional file 1: The Flow Cytometric assay results of per-patient levels of ROS at baseline (B) and week 26 (A).
View article: Changes in serum levels of CEA and CA19-9 tumor markers in different stages of patients with colorectal cancer
Changes in serum levels of CEA and CA19-9 tumor markers in different stages of patients with colorectal cancer Open
Background: Colorectal cancer is one of the most common gastrointestinal cancers worldwide with a high prevalence among middle-aged people. This study aimed to evaluate and compare changes in serum levels of carcinoembryonic antigen (CEA) …
View article: Study rationale and design of a study of EMPAgliflozin’s effects in patients with type 2 diabetes mellitus and Coronary ARtery disease: the EMPA-CARD randomized controlled trial
Study rationale and design of a study of EMPAgliflozin’s effects in patients with type 2 diabetes mellitus and Coronary ARtery disease: the EMPA-CARD randomized controlled trial Open
Background Recent trials have revealed that sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are effective against hyperglycemia and also reduce micro- and macro-vascular complications in patients with type 2 diabetes mellitus (T2DM). …
View article: Clinicopathological, Immunohistochemical, and <i>PMS2 </i>Gene Expression Profiling of Patients with Sporadic Colorectal Cancer
Clinicopathological, Immunohistochemical, and <i>PMS2 </i>Gene Expression Profiling of Patients with Sporadic Colorectal Cancer Open
Background: The DNA mismatch repair (MMR) system is one of the molecular pathways involved in colorectal cancer (CRC) carcinogenesis that consists of several genes, including MLH1 (MutL homolog 1), MSH6 (MutS homolog 6), MSH2 (MutS homolog…
View article: Serum Interleukin 17 and Interleukin 33 in Vitiligo Egyptian Patients
Serum Interleukin 17 and Interleukin 33 in Vitiligo Egyptian Patients Open
Background: Vitiligo is an acquired depigmented disorder characterized by milky-white macules in the skin. Interleukin-17 has important role in autoimmune diseases development like vitiligo. Interleukin-33 is released after tissue damage o…
View article: Apoptosis induction by siRNA targeting integrin-β1 and regorafenib/DDAB-mPEG-PCL hybrid nanoparticles in regorafenib-resistant colon cancer cells.
Apoptosis induction by siRNA targeting integrin-β1 and regorafenib/DDAB-mPEG-PCL hybrid nanoparticles in regorafenib-resistant colon cancer cells. Open
Colorectal cancer (CRC) is regarded as the third most common cancer worldwide. Although Regorafenib as a receptor tyrosine kinase inhibitor (RTKI) disrupts tumor growth and angiogenesis in metastatic CRC (mCRC) patients, drug resistance le…
View article: Study Rationale and Design of a Study of Empagliflozin’s Effects in Patients With Type 2 Diabetes Mellitus and Coronary ARtery&nbsp;Disease: The EMPA-CARD&nbsp;Randomized Controlled Trial
Study Rationale and Design of a Study of Empagliflozin’s Effects in Patients With Type 2 Diabetes Mellitus and Coronary ARtery Disease: The EMPA-CARD Randomized Controlled Trial Open
Background: Recent trials have revealed that sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are effective against hyperglycemia and also reduce micro- and macro-vascular complications in patients with type 2 diabetes mellitus (T2DM).…
View article: Circulating Irisin Levels and Redox Status Markers in Patients with Gastric Cancer: A Case-Control Study
Circulating Irisin Levels and Redox Status Markers in Patients with Gastric Cancer: A Case-Control Study Open
According to the finding, the increased serum levels of irisin in GC patients can play a potential role in the early diagnosis of the GC patients; hence, this peptide can be employed as a new diagnostic indicator of GC..
View article: Oxidative toxic stress and p53 level in healthy subjects occupationally exposed to outdoor air Pollution – a cross-sectional study in Iran
Oxidative toxic stress and p53 level in healthy subjects occupationally exposed to outdoor air Pollution – a cross-sectional study in Iran Open
The findings obtained confirmed the implication of air pollution in the development of OTS, and suggested useful biomarkers to evaluate the air pollution-induced harmful effects on human health in the polluted areas.
View article: ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients
ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients Open
The results suggested that genetic variation in ALOX12 might influence BMD variations in our recruited participants. As for the patients with lower serum Se levels, it was observed that serum Se deficiency was accompanied by some ALOX12 va…
View article: Preliminary study showing no association between G238A (rs361525) tumor necrosis factor-α (TNF-α) gene polymorphism and its serum level, hormonal and biochemical aspects of polycystic ovary syndrome
Preliminary study showing no association between G238A (rs361525) tumor necrosis factor-α (TNF-α) gene polymorphism and its serum level, hormonal and biochemical aspects of polycystic ovary syndrome Open
View article: Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran
Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran Open
Background: Colorectal cancer susceptibility may correlate with the Klotho gene G-395A and C1818T polymorphisms. This study aims to evaluate the relationship between a Klotho single nucleotide polymorphism and IGF-1 with risk of colorectal…
View article: The assessment of metabolite alteration induced by –OH functionalized multi-walled carbon nanotubes in mice using NMR-based metabonomics
The assessment of metabolite alteration induced by –OH functionalized multi-walled carbon nanotubes in mice using NMR-based metabonomics Open
Introduction: There is a fundamental need to characterize multiwalled carbon nanotubes (MWCNTs) toxicity to guarantee their safe application. Functionalized MWCNTs have recently attracted special interest in order to enhance …
View article: Evaluation of the Level of Zinc and Malondialdehyde in Basal Cell Carcinoma.
Evaluation of the Level of Zinc and Malondialdehyde in Basal Cell Carcinoma. Open
All the patients with BCC showed a significant MDA serum in comparison with control group. However, significant decrease in zinc serum of the patients was seen that is because of consuming zinc during oxidative stress process so topical us…
View article: Histopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles
Histopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles Open
The aim of this study was to investigate the histopathological changes in zebrafish larvae following embryonic exposure to nanoparticles of magnesium oxide (MgONPs). The toxicity of metal oxide nanoparticles is attracting increasing attent…
View article: Evaluation of hypoxia inducible factor-1 alpha gene expression in colorectal cancer stages of Iranian patients
Evaluation of hypoxia inducible factor-1 alpha gene expression in colorectal cancer stages of Iranian patients Open
HIF-1 alpha gene expression increased in earlier up to metastasis stages of CRC, but the assessment of HIF-1 alpha gene expression has not important role in the diagnosis of cancer in early stages and classification of carcinoma because th…