Explanipedia

Repurposing of FDA-Approved Antiviral Drugs Against Monkeypox Virus: Comparative In Vitro Screening and Structure Based In Silico Studies Open

Yassmin Moatasim, Omnia Kutkat, Mokhtar R. Gomaa, M. Yousif Nabil, Ahmed A. El‐Rashedy , et al. · 2025

Background/Objectives: Monkeypox is endemic to the African continent and has recently garnered global attention due to reported outbreaks in non-endemic nations. No approved drug is available for non-severe cases, and some isolates gained …

Genetic Characterization and Pathogenesis of Highly Pathogenic Avian Influenza Virus A (H5N1) Isolated in Egypt During 2021–2023 Open

Mina Nabil Kamel, Yassmin Moatasim, Basma Emad Aboulhoda, Mokhtar R. Gomaa, Ahmed El Taweel , et al. · 2025

Highly pathogenic avian influenza (HPAI) viruses have recently had a substantial impact on global poultry production and public health. In Egypt, clade 2.3.4.4b HPAI H5N1 viruses were first isolated from wild birds in 2021 and then became …

Author Correction: Transmission dynamics of avian influenza viruses in Egyptian poultry markets Open

Sara H. Mahmoud, Mokhtar R. Gomaa, Ahmed El Taweel, Yassmin Moatasim, Mina Nabil Kamel , et al. · 2025

Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024 Open

Rabeh El‐Shesheny, Mokhtar R. Gomaa, Mohamed El Sayes, Mina Nabil Kamel, Ahmed El Taweel , et al. · 2025

Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt, June 2024. Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment …

Newcastle disease virus in Egyptian domestic poultry, 2019–2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus Open

Ahmed El Taweel, Mohamed El Sayes, Asmaa M. Maatouq, Mokhtar R. Gomaa, Yassmin Moatasim , et al. · 2025

Background: Newcastle Disease Virus (NDV) is a major viral disease of poultry that causes outbreaks in chickens in Egypt. Aim: The aim of this study was to determine the prevalence and molecular characteristics of NDV and its cocirculation…

Genomic Diversity and Evolution of Identified SARS-CoV-2 Variants in Iraq Open

Ahmed A. Al-Mankhee, Yassmin Moatasim, Ahmed El Taweel, Mokhtar R. Gomaa, Omar A. Rabiee , et al. · 2024

The COVID-19 pandemic caused by the SARS-CoV-2 virus continues to circulate worldwide, causing the deaths of millions of people. The continuous circulation of the virus, its genetic diversity, the emergence of new variants with increased t…

Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models Open

Yassmin Moatasim, Basma Emad Aboulhoda, Mokhtar R. Gomaa, Ahmed El Taweel, Omnia Kutkat , et al. · 2024

Since its first isolation from migratory birds in Egypt in 2016, highly pathogenic avian influenza (HPAI) H5N8 has caused several outbreaks among domestic poultry in various areas of the country affecting poultry health and production syst…

Highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b in wild rats in Egypt during 2023 Open

Omnia Kutkat, Mokhtar R. Gomaa, Yassmin Moatasim, Ahmed El Taweel, Mina Nabil Kamel , et al. · 2024

We detected highly pathogenic avian influenza A(H5N1) virus in wild rats collected from a rural area in Giza, Egypt, near poultry farms, markets, and backyard flocks. Sequence and phylogenetic analyses indicated that the virus from the rat…

Correction: El-Shesheny et al. Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Wild Birds and Live Bird Markets, Egypt. Pathogens 2023, 12, 36 Open

Rabeh El‐Shesheny, Yassmin Moatasim, Sara H. Mahmoud, Yi Song, Ahmed El Taweel , et al. · 2024

Text Correction [...]

Transmission dynamics of avian influenza viruses in Egyptian poultry markets Open

Sara H. Mahmoud, Mokhtar R. Gomaa, Ahmed El Taweel, Yassmin Moatasim, Mina Nabil Kamel , et al. · 2024

Live bird markets (LBMs) are considered hotspots for Avian Influenza Viruses (AIVs). In such markets, AIVs pose threats to both poultry and public health. Within LBMs, AIVs spread through various routes, including direct contact, environme…

Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E Open

Yassmin Moatasim, Omnia Kutkat, Ahmed M. Osman, Mokhtar R. Gomaa, Faten A. Okda , et al. · 2023

Repurposing vitamins as antiviral supporting agents is a rapid approach used to control emerging viral infections. Although there is considerable evidence supporting the use of vitamin supplementation in viral infections, including severe …

Double-antibody-based nano-biosensing system for the onsite monitoring of SARS-CoV-2 variants Open

Heba A. Hussein, Ahmed Kandeil, Mokhtar R. Gomaa, Rabeay Y. A. Hassan · 2023

The fast and reliable diagnosis of COVID-19 is the foremost priority for promoting public health interventions. Therefore, double-antibody-based immunobiosensor chips were designed, constructed, and exploited for clinical diagnosis. Gold n…

Comparison of SARS-Cov-2 omicron variant with the previously identified SARS-Cov-2 variants in Egypt, 2020–2022: insight into SARS-Cov-2 genome evolution and its impact on epidemiology, clinical picture, disease severity, and mortality Open

Amr Kandeel, Yassmin Moatasim, Manal Fahim, Hala BahaaEldin, Rabeh El‐Shesheny , et al. · 2023

We are underestimating, again, the true burden of H5N1 in humans Open

Mokhtar R. Gomaa, Yassmin Moatasim, Ahmed El Taweel, Sara H. Mahmoud, Amira S. El Refay , et al. · 2023

Whole-Genome Sequence of a Human Monkeypox Virus Strain Detected in Egypt Open

Wael H. Roshdy, Rabeh El‐Shesheny, Yassmin Moatasim, Mina Nabil Kamel, Shaymaa Showky , et al. · 2023

Monkeypox virus has recently been detected in multiple countries. Two cases of monkeypox virus were reported in Egypt as part of an ongoing international outbreak. We report the whole-genome sequence of a monkeypox virus that was retrieved…

Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Wild Birds and Live Bird Markets, Egypt Open

Rabeh El‐Shesheny, Yassmin Moatasim, Sara H. Mahmoud, Yi Song, Ahmed El Taweel , et al. · 2022

Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In…

SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic Open

Wael H. Roshdy, Mohamed K. Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson , et al. · 2022

COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part of the national genomic surveillance, 1027 SARS-CoV-2 near whole-genomes were generated…

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies Open

Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair, Mokhtar R. Gomaa , et al. · 2022

Induced humoral immunity of different types of vaccines against most common variants of SARS-CoV-2 in Egypt prior to Omicron outbreak Open

Rabeh El‐Shesheny, Ahmed El Taweel, Mokhtar R. Gomaa, Wael H. Roshdy, Ahmed Kandeil , et al. · 2022

Prevalence and determinants of SARS-CoV-2 neutralizing antibodies in Lebanon Open

Omar Bahlawan, Rebecca Badra, Hanna Semaan, Nancy Fayad, Mina Nabil Kamel , et al. · 2022

Incidence and seroprevalence of seasonal influenza a viruses in Egypt: Results of a community‐based cohort study Open

Mokhtar R. Gomaa, Rebecca Badra, Amira S. El Refay, Ahmed Kandeil, Mina Nabil Kamel , et al. · 2022

Background H1N1 and H3N2 influenza A viruses circulate in people as seasonal influenza viruses. Data on influenza infection rates and circulation in demographic subpopulations in Egypt are limited. In this study, we aimed to determine the …

SARS-CoV-2 Genetic diversity and lineage dynamics of in Egypt Open

Wael H. Roshdy, Mohamed K. Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson , et al. · 2022

COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part of national genomic surveillance, 1,027 SARS-CoV-2 near whole-genomes had been generate…

Antiviral activity of chitosan nanoparticles encapsulating silymarin (Sil–CNPs) against SARS-CoV-2 (in silico and in vitro study) Open

Samah A. Loutfy, Ahmed I. Abdel-Salam, Yassmin Moatasim, Mokhtar R. Gomaa, Nasra F. Abdel Fattah , et al. · 2022

To develop a specific treatment against COVID-19, we investigated silymarin–chitosan nanoparticles (Sil–CNPs) as an antiviral agent against SARS-CoV-2 using in silico and in vitro approaches.

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies Open

Dina B. Mahmoud, Walaa M. Ismail, Yassmin Moatasim, Omnia Kutkat, Aliaa Nabil ElMeshad , et al. · 2021

Determinants of having severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in Egypt Open

Amira S. El Refay, Sara H. Mahmoud, Mohamed A. Marouf, Mokhtar R. Gomaa, Ahmed El Taweel , et al. · 2021

Background Reported laboratory‐confirmed COVID‐19 cases underestimate the true burden of disease as cases without laboratory confirmation, and asymptomatic and mild cases are missed by local surveillance systems. Population‐based seropreva…

Sinapic Acid Suppresses SARS CoV-2 Replication by Targeting Its Envelope Protein Open

Raha Orfali, Mostafa E. Rateb, Hossam M. Hassan, Mona Alonazi, Mokhtar R. Gomaa , et al. · 2021

SARS CoV-2 is still considered a global health issue, and its threat keeps growing with the emergence of newly evolved strains. Despite the success in developing some vaccines as a protective measure, finding cost-effective treatments is u…

Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort Open

Mokhtar R. Gomaa, Amira S. El Refay, Mahmoud Shehata, Ahmed Kandeil, Mina Nabil Kamel , et al. · 2021

SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household contacts. However, household person-to-person transmission studies are limited. Households participatin…

Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies Open

Ahmed Kandeil, Ahmed Mostafa, Rehab Hegazy, Rabeh El‐Shesheny, Ahmed El Taweel , et al. · 2021

Since the emergence of SARS-CoV-2 at the end of 2019, 64 candidate vaccines are in clinical development and 173 are in the pre-clinical phase. Five types of vaccines are currently approved for emergency use in many countries (Inactivated, …

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2 Open

Ahmed Mostafa, Ahmed Kandeil, Yaseen A.M.M. Elshaier, Omnia Kutkat, Yassmin Moatasim , et al. · 2020

(1) Background: Drug repositioning is an unconventional drug discovery approach to explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue to alleviate the COVID-19 pandemic disease. (2) Methods: Herein,…

Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibodies in Egyptian Convalescent Plasma Donors Open

Mokhtar R. Gomaa, Ahmed Kandeil, Ahmed Mostafa, Wael H. Roshdy, Ahmed E. Kayed , et al. · 2020

Using convalescent plasma as immunotherapy is an old method for treatment of infectious diseases. Several countries have recently allowed the use of such therapy for the treatment of COVID-19 patients especially those who are critically il…

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