Moli Huang YOU? Author Swipe

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From cells to clinic: Single-cell transcriptomics shaping the future of orthopedics Open

Qiuyuan Wang, Moli Huang, Jiong Jiong Guo · 2025

This article systematically reviews the cellular heterogeneity, molecular mechanisms and immune microenvironment of orthopedic diseases (such as osteoarthritis, rheumatoid arthritis, intervertebral disc degeneration, osteosarcoma) by singl…

The Characteristically Slow Proton Transfer Coupled to Platinum Oxidation in Alkaline Polyelectrolyte as Elucidated at the Molecular Level Open

Moli Huang, Wenhui Ling, Zhangrui Wang, Yang Lu, Hong-Ning Shen , et al. · 2025

The proton transfer in alkaline polyelectrolyte membrane (APEM)/electrode interfaces is significantly coupled to the electrochemical reactions in energy conversion and green synthesis. The OH^- in APEM/electrode interfaces is cha…

Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosis Open

Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong , et al. · 2025

National Natural Science Foundation of China (82430001, 81930001, and 81900059), Shanghai Shenkang Hospital Development Center (SHDC2020CR3063B), Department of Science and Technology of Shandong Province (2024HWYQ-058).

Pyroptosis: A promising biomarker for predicting colorectal cancer prognosis and enhancing immunotherapy efficacy Open

Jiayi Wang, Y. Lu, Fang Li, Moli Huang · 2024

In this editorial, we comment on the article by Zhu et al published in the recent issue of the World Journal of Clinical Oncology . We focus specifically on the characteristics and mechanisms of pyroptosis and the impact of changes in the …

Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma Open

Shufan Zhang, Rong Jiang, Changguo Wang, Manqiu Yang, Tao Wang , et al. · 2024

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data Open

Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang · 2023

In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance. We developed circlehunter…

Supplementary Figures from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

Supplementary Figure 1. Distribution of putative targets of the top-ranked small molecules Supplementary Figure 2. CDK7 silencing significantly inhibited cells growth Supplementary Figure 3. Cell viability assay of C666-1 cells treated wit…

Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southeast Asia and Southern China. The pathogenic mechanisms of NPC, particularly those involving epigenetic dysregulation, remain largely elusive, ha…

Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southeast Asia and Southern China. The pathogenic mechanisms of NPC, particularly those involving epigenetic dysregulation, remain largely elusive, ha…

Supplementary Figures from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

Supplementary Figure 1. Distribution of putative targets of the top-ranked small molecules Supplementary Figure 2. CDK7 silencing significantly inhibited cells growth Supplementary Figure 3. Cell viability assay of C666-1 cells treated wit…

Supplementary_table 1-6, 8-12 from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

The IC50 (nM) values, RNA-seq, ChIP seq and motif analysis in NPC cell lines

Supplementary Table 7 from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

The Highest Expression Genes in NPC Compare With RNA-seq Results From 675 Human Cancer Cell Lines

Supplementary_table 1-6, 8-12 from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

The IC50 (nM) values, RNA-seq, ChIP seq and motif analysis in NPC cell lines

Supplementary Table 7 from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open

Yuan Jiang, Yan‐Yi Jiang, Anand Mayakonda, Moli Huang, Ling‐Wen Ding , et al. · 2023

The Highest Expression Genes in NPC Compare With RNA-seq Results From 675 Human Cancer Cell Lines

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis Open

Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang · 2023

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest Open

Chao Li, Yuming Feng, Zhenxin Fu, Junjie Deng, Yue Gu , et al. · 2022

Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica Open

Yue Hong, Shan Shan, Ye Gu, Haidong Huang, Quncheng Zhang , et al. · 2022

Isovalerylspiramycin I suppresses non-small cell lung carcinoma growth through ROS-mediated inhibition of PI3K/AKT signaling pathway Open

Zeyu Liu, Moli Huang, Yue Hong, Shaoyang Wang, Yongle Xu , et al. · 2022

Novel drugs are required for non-small cell lung cancer (NSCLC) treatment urgently. Repurposing old drugs as new treatments is a practicable approach with time and cost savings. Some studies have shown that carrimycin, a Chinese Food and D…

Topography of transcriptionally active chromatin in glioblastoma Open

Liang Xu, Ye Chen, Yulun Huang, Edwin Sandanaraj, John S. Yu , et al. · 2021

Profiling of active gene-regulatory DNA elements in brain cancer tissues illuminates disease biology and therapeutic targets.

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma Open

Xianping Shi, Yueyuan Zheng, Liling Jiang, Bo Zhou, Wei Yang , et al. · 2020

Core regulatory circuitry (CRC)-dependent transcriptional network is critical for developmental tumors in children and adolescents carrying few gene mutations. However, whether and how CRC contributes to transcription regulation in Ewing s…

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma Open

Xianping Shi, Yueyuan Zheng, Liling Jiang, Bo Zhou, Wei Yang , et al. · 2020

Core regulatory circuitry (CRC)-dependent transcriptional network is critical for developmental tumors in children and young adults carrying few gene mutations. However, whether and how CRC contributes to transcription regulation in Ewing …

dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq Open

Moli Huang, Yunpeng Wang, Manqiu Yang, Jun Yan, Henry Yang , et al. · 2019

Summary Cancer hallmarks rely on its specific transcriptional programs, which are dysregulated by multiple mechanisms, including genomic aberrations in the DNA regulatory regions. Genome-wide association studies have shown many variants ar…

The Molecular Evolution of Circadian Clock Genes in Spotted Gar (Lepisosteus oculatus) Open

Yi Sun, Chao Liu, Moli Huang, Jian Huang, Changhong Liu , et al. · 2019

Circadian rhythms are biological rhythms with a period of approximately 24 h. While canonical circadian clock genes and their regulatory mechanisms appear highly conserved, the evolution of clock gene families is still unclear due to sever…

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma Open

Li Chen, Moli Huang, Jasmine Plummer, Jian Pan, Yan Jiang , et al. · 2019

Objective While oesophageal squamous cell carcinoma remains infrequent in Western populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to eightfold over the past four decades. We aimed to characterise oesoph…

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma Open

Ye Chen, Liang Xu, Anand Mayakonda, Moli Huang, Deepika Kanojia , et al. · 2019

Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1 Open

Lehang Lin, Moli Huang, Xianping Shi, Anand Mayakonda, Kaishun Hu , et al. · 2018

As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the tran…

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression Open

Yuan Jiang, Yan‐Yi Jiang, Jian‐Jun Xie, Anand Mayakonda, Masaharu Hazawa , et al. · 2018

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma Open

Liang Xu, Ye Chen, Anand Mayakonda, Lynnette Koh, Yuk Kien Chong , et al. · 2018

Significance Glioblastoma (GBM) cells develop intrinsic or acquired insensitiveness to BET bromodomain inhibitors (BBIs) yet develop persistent BET protein dependency. Selective degradation of BET proteins by a next-generation chemical com…

Clonality and clonal evolution analysis of paediatric <span>ALL</span> based on B‐cell receptor/T‐cell receptor rearrangement Open

Ling‐Wen Ding, Kar‐Tong Tan, Qiao‐Yang Sun, Zhentang Lao, Henry Yang , et al. · 2018

The prognosis of paediatric acute lymphoblastic leukaemia (ALL) has greatly improved in recent decades, with currently 85–90% of the patients cured with routine chemotherapy. However, once the disease relapses, the leukaemic cells often be…

dbCoRC: a database of core transcriptional regulatory circuitries modeled by H3K27ac ChIP-seq signals Open

Moli Huang, Ye Chen, Manqiu Yang, An‐Yuan Guo, Ying Xu , et al. · 2017

Core transcription regulatory circuitry (CRC) is comprised of a small group of self-regulated transcription factors (TFs) and their interconnected regulatory loops. Studies from embryonic stem cells and other cellular models have revealed …

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