Molly E. Ogle
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View article: Senescence-Induced Lipidome Alterations in Mesenchymal Stromal Cells
Senescence-Induced Lipidome Alterations in Mesenchymal Stromal Cells Open
Mesenchymal stromal cells (MSCs) show great promise as a clinical treatment for a variety of diseases, but their susceptibility to senescence during culture reduces the therapeutic potential and limits cell expansion. In this study, we exp…
View article: Toward Machine Learning Electrospray Ionization Sensitivity Prediction for Semiquantitative Lipidomics in Stem Cells
Toward Machine Learning Electrospray Ionization Sensitivity Prediction for Semiquantitative Lipidomics in Stem Cells Open
Specificity, sensitivity, and high metabolite coverage make mass spectrometry (MS) one of the most valuable tools in metabolomics and lipidomics. However, translation of metabolomics MS methods to multiyear studies conducted across multipl…
View article: Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets
Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets Open
Understanding the immune response to hydrogel implantation is critical for the design of immunomodulatory biomaterials. To study the progression of inflammation around poly(ethylene glycol) hydrogels presenting Arg-Gly-Asp (RGD) peptides a…
View article: Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids
Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids Open
Cell therapies are expected to increase over the next decade due to increasing demand for clinical applications. Mesenchymal stromal cells (MSCs) have been explored to treat a number of diseases, with some successes in early clinical trial…
View article: Nanofiber-Based Delivery of Bioactive Lipids Promotes Pro-regenerative Inflammation and Enhances Muscle Fiber Growth After Volumetric Muscle Loss
Nanofiber-Based Delivery of Bioactive Lipids Promotes Pro-regenerative Inflammation and Enhances Muscle Fiber Growth After Volumetric Muscle Loss Open
Volumetric muscle loss (VML) injuries after extremity trauma results in an important clinical challenge often associated with impaired healing, significant fibrosis, and long-term pain and functional deficits. While acute muscle injuries t…
View article: Modulating local S1P receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury
Modulating local S1P receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury Open
Regeneration of skeletal muscle after volumetric injury is thought to be impaired by a dysregulated immune microenvironment that hinders endogenous repair mechanisms. Such defects result in fatty infiltration, tissue scarring, chronic infl…
View article: Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics
Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics Open
SUMMARY Throughout life, skeletal muscle, the arbiter of voluntary movements, is maintained by a population of skeletal muscle-dedicated stem cells, called muscle satellite cells (MuSCs). Similar to other adult stem cells, the function of …
View article: Abstract 107: SPADE Analysis Reveals The Recruitment Of Rare Immune Cell Subtypes To Site Of Injury Following Treatment With Immunomodulatory Hydrogels
Abstract 107: SPADE Analysis Reveals The Recruitment Of Rare Immune Cell Subtypes To Site Of Injury Following Treatment With Immunomodulatory Hydrogels Open
Purpose - Wound care following surgical procedures involves careful management, reducing risk of infection, and maximizing tissue oxygenation. Even with new strides in biological and synthetic products, achieving adequate wound care remain…
View article: Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps
Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps Open
The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. …
View article: Muscle Stem Cell Niche Dysregulation in Volumetric Muscle Loss Injury
Muscle Stem Cell Niche Dysregulation in Volumetric Muscle Loss Injury Open
Skeletal muscle has a remarkable regenerative capacity; however, after volumetric muscle loss (VML) due to traumatic injury or surgery this regenerative response is significantly diminished, causing chronic functional deficits. The critica…
View article: Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury
Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury Open
Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cel…
View article: Dual Affinity Heparin-Based Hydrogels Achieve Pro-Regenerative Immunomodulation and Microvascular Remodeling
Dual Affinity Heparin-Based Hydrogels Achieve Pro-Regenerative Immunomodulation and Microvascular Remodeling Open
The immune response to biomaterial implants critically regulates functional outcomes such as vascularization, transplant integration/survival, and fibrosis. To create "immunologically smart" materials, the host-material response may be eng…
View article: Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche
Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche Open
Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during homeostasis and at increased rates during stress; however, the mechanisms regulating their trafficking remain incompletely understood. Here we describe a n…