Molly L. Nelson
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View article: Spatially-distinct programming of macrophage diversity within the granulomas of <i>Mycobacterium tuberculosis</i> infected nonhuman primates
Spatially-distinct programming of macrophage diversity within the granulomas of <i>Mycobacterium tuberculosis</i> infected nonhuman primates Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is defined by granulomas— immune aggregates that either contain or support bacterial replication. Macrophages, fundamental components of these lesions, are crucial to TB pathog…
View article: Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity Open
Myeloid cells are key constituents of tuberculosis (TB) granulomas. They are the major target of pathogen infection and play central roles in pathogen control, antigen presentation, adaptive immune cell recruitment, and tissue homeostasis.…