Molly R. Davies
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View article: UK-based mental health professionals’ perceptions of genetic and environmental risk for psychiatric conditions
UK-based mental health professionals’ perceptions of genetic and environmental risk for psychiatric conditions Open
Objective Psychiatric conditions arise from a complex interplay of genetics and environment. Many people struggle to interpret genetic risk, leading to distress and inadequately informed decisions. Mental health professionals are often the…
View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: A randomised controlled feasibility trial of FREED-Mobile, a smartphone friendly decision tool, designed to facilitate help-seeking in young people with eating disorders
A randomised controlled feasibility trial of FREED-Mobile, a smartphone friendly decision tool, designed to facilitate help-seeking in young people with eating disorders Open
Background: Early intervention increases the likelihood of eating disorder (ED) recovery but many young people delay help-seeking. We developed a smartphone-friendly, online decision-making tool to address this gap (FREED-Mobile [FREED-M])…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-modal decision-making tool (FREED-M) to improve help-seeking
Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-modal decision-making tool (FREED-M) to improve help-seeking Open
View article: Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease
Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease Open
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairme…
View article: Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome
Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome Open
Despite the widespread use of cognitive-behavioural therapy (CBT), only about half of patients respond favourably. Understanding whether relevant psychological processes are associated with treatment response could help identify patients a…
View article: Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: findings from a service evaluation
Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: findings from a service evaluation Open
Background: Timely intervention is beneficial to the effectiveness of eating disorder (ED) treatment, but limited capacity within ED services means that these disorders are often not treated with sufficient speed. This service evaluation e…
View article: Seeking help for mental health during the COVID-19 pandemic: A longitudinal analysis of adults’ experiences with digital technologies and services
Seeking help for mental health during the COVID-19 pandemic: A longitudinal analysis of adults’ experiences with digital technologies and services Open
The COVID-19 pandemic brought about dramatic changes in how patients access healthcare from its outset. Lockdown restrictions and remote working led to a proliferation of digital technologies and services, which also impacted mental health…
View article: Management of fraudulent participants in online research: Practical recommendations from a randomized controlled feasibility trial
Management of fraudulent participants in online research: Practical recommendations from a randomized controlled feasibility trial Open
Objective Fraudulent participation is an escalating concern for online clinical trials and research studies and can have a significant negative impact on findings. We aim to shed light on the risk and to provide practical recommendations f…
View article: The genetic overlap between functional impairment and severity of depression and anxiety symptoms
The genetic overlap between functional impairment and severity of depression and anxiety symptoms Open
Background Impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence suggesting that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The United Kingdom Eating Disorders Genetics Initiative
The United Kingdom Eating Disorders Genetics Initiative Open
Objective The United Kingdom Eating Disorders Genetics Initiative (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic et…
View article: Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy
Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy Open
Underlying classes capture differences between patient symptom trajectories during psychological therapy. This has not been explored for one-to-one internet-delivered therapy or functional impairment trajectories. Patients experiencing dep…
View article: Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
View article: The network structure of mania symptoms differs between people with and without binge eating
The network structure of mania symptoms differs between people with and without binge eating Open
Objectives People with bipolar disorder who also report binge eating have increased psychopathology and greater impairment than those without binge eating. Whether this co‐occurrence is related to binge eating as a symptom or presents diff…
View article: Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy cases
Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy cases Open
Depression is a risk factor for Alzheimer’s disease (AD), but evidence for their genetic relationship is mixed. Assessing depression symptom specific genetic associations may better clarify this relationship. Using data from the UK Biobank…
View article: Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder
Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder Open
The Mood Disorder Questionnaire (MDQ) is a common screening tool for bipolar disorder that assesses manic symptoms. Its utility for genetic studies of mania or bipolar traits has not been fully examined. We psychometrically compared the MD…
View article: Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: Findings from a service evaluation conducted during the COVID-19 pandemic
Virtually delivered guided self-help for binge eating disorder and bulimia nervosa: Findings from a service evaluation conducted during the COVID-19 pandemic Open
Background: Timely intervention is beneficial to the effectiveness of eating disorder (ED) treatment, but limited capacity within ED services means that these disorders are often not treated with sufficient speed. This service evaluation e…
View article: Additional file 2 of Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Additional file 2 of Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
Additional file 2. Output from the statistical models.
View article: Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
Background: The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed to facilitate re-contact of participants for mental health research. At the start of th…
View article: Trajectories of depression and anxiety symptom severity during psychological therapy for common mental health problems
Trajectories of depression and anxiety symptom severity during psychological therapy for common mental health problems Open
Background There is substantial variation in patient symptoms following psychological therapy for depression and anxiety. However, reliance on endpoint outcomes ignores additional interindividual variation during therapy. Knowing a patient…
View article: Factors associated with anxiety disorder comorbidity
Factors associated with anxiety disorder comorbidity Open
View article: Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants
Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants Open
View article: The Eating Disorders Genetics Initiative (EDGI) United Kingdom
The Eating Disorders Genetics Initiative (EDGI) United Kingdom Open
Objective The Eating Disorders Genetics Initiative United Kingdom (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic ae…
View article: Risk and protective factors for new‐onset binge eating, low weight, and self‐harm symptoms in >35,000 individuals in the <scp>UK</scp> during the <scp>COVID</scp>‐19 pandemic
Risk and protective factors for new‐onset binge eating, low weight, and self‐harm symptoms in >35,000 individuals in the <span>UK</span> during the <span>COVID</span>‐19 pandemic Open
Objective The disruption caused by the COVID‐19 pandemic has been associated with poor mental health, including increases in eating disorders and self‐harm symptoms. We investigated risk and protective factors for the new onset of these sy…
View article: Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK)
Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK) Open
View article: Risk and protective factors for new onset binge eating, low weight, and self-harm symptoms in over 25,000 individuals in the UK during the COVID-19 pandemic
Risk and protective factors for new onset binge eating, low weight, and self-harm symptoms in over 25,000 individuals in the UK during the COVID-19 pandemic Open
Objective: The disruption caused by the COVID-19 pandemic has been associated with poor mental health, including increases in eating disorder and self-harm symptoms. We investigated risk and protective factors for new onset of these sympto…