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View article: Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk
Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk Open
Background Obesity is a risk factor for several cancers, but the mechanistic basis is poorly understood. We sought to identify circulating metabolites mediating the effect of obesity on the risk of eight common cancers. Methods Using Europ…
View article: Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy
Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy Open
Although treatment options for B-cell malignancies have expanded, many patients continue to face limited response rates, highlighting an urgent need for new therapeutic targets. To prioritize candidate drug targets for B-cell malignancies,…
View article: Appraising ascorbic acid as a chemoprevention agent for acute myeloid leukaemia using Mendelian Randomisation
Appraising ascorbic acid as a chemoprevention agent for acute myeloid leukaemia using Mendelian Randomisation Open
View article: Deciphering the genetics and mechanisms of predisposition to multiple myeloma
Deciphering the genetics and mechanisms of predisposition to multiple myeloma Open
View article: Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis
Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis Open
View article: Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers
Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers Open
View article: Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls
Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls Open
View article: Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls
Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls Open
For many cancers there are few well-established risk factors. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify causal relationships. …
View article: Author Correction: Functional dissection of inherited non-coding variation influencing multiple myeloma risk
Author Correction: Functional dissection of inherited non-coding variation influencing multiple myeloma risk Open
View article: Exploiting gene dependency to inform drug development for multiple myeloma
Exploiting gene dependency to inform drug development for multiple myeloma Open
Despite recent advances in therapy, multiple myeloma essentially remains an incurable malignancy. Targeting tumour-specific essential genes, which constitute a druggable dependency, potentially offers a strategy for developing new therapeu…
View article: Functional dissection of inherited non-coding variation influencing multiple myeloma risk
Functional dissection of inherited non-coding variation influencing multiple myeloma risk Open
View article: Author Correction: Germline variants at SOHLH2 influence multiple myeloma risk
Author Correction: Germline variants at SOHLH2 influence multiple myeloma risk Open
View article: Germline variants at SOHLH2 influence multiple myeloma risk
Germline variants at SOHLH2 influence multiple myeloma risk Open
View article: Search for multiple myeloma risk factors using Mendelian randomization
Search for multiple myeloma risk factors using Mendelian randomization Open
The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to sear…
View article: Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes Open
View article: A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study
A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study Open
Background Primary central nervous system lymphoma (PCNSL) is a rare form of extra-nodal non-Hodgkin lymphoma. PCNSL is a distinct subtype of non-Hodgkin lymphoma, with over 95% of tumors belonging to the diffuse large B-cell lymphoma (DLB…
View article: Regions of homozygosity as risk factors for multiple myeloma
Regions of homozygosity as risk factors for multiple myeloma Open
Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole‐genome homozygosi…
View article: Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma Open
View article: Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology
Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology Open
View article: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Open
View article: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma Open
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replicat…
View article: Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism
Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism Open
Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influenc…
View article: Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach
Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach Open
Multiple myeloma (MM) accounts for around 15% of new cases and 20% of deaths amongst patients diagnosed with haematological malignancy. To date, few risk factors have been robustly confirmed for MM, these include increasing age, male sex, …