Momoko Horikoshi
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View article: Interplay between host genetics and gut microbiome composition in the Japanese population
Interplay between host genetics and gut microbiome composition in the Japanese population Open
Background Host genetics significantly influence the composition of the gut microbiota, but this relationship remains poorly understood, especially in non-European populations. This study aims to investigate the associations between host g…
View article: Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries Open
Summary Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utili…
View article: Decomposing type 2 diabetes genetics into population-specific features by 600,000 East-Asians
Decomposing type 2 diabetes genetics into population-specific features by 600,000 East-Asians Open
Background: Type 2 diabetes (T2D) is a highly heterogeneous metabolic trait, with a higher prevalence in East Asians. This study aims to elucidate the East Asian-specific genetic architecture underlying T2D. Methods: We conducted the large…
View article: Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance Open
Orchestrated hormonal interactions in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B,…
View article: Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Open
View article: Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population
Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population Open
To improve imputation quality for genome-wide association studies (GWAS) conducted on the Japanese population, we developed and evaluated four Japanese population-specific reference panels. These panels were constructed through the augment…
View article: Population-specific putative causal variants shape quantitative traits
Population-specific putative causal variants shape quantitative traits Open
View article: Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance Open
Orchestrated hormonal interacts in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B, in…
View article: SMIM1 absence is associated with reduced energy expenditure and excess weight
SMIM1 absence is associated with reduced energy expenditure and excess weight Open
This work was funded by the National Institute of Health Research, British Heart Foundation, and NHS Blood and Transplant.
View article: Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing
Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing Open
We generated Japanese Encyclopedia of Whole-Genome/Exome Sequencing Library (JEWEL), a high-depth whole-genome sequencing dataset comprising 3256 individuals from across Japan. Analysis of JEWEL revealed genetic characteristics of the Japa…
View article: A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Open
Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-Europe…
View article: Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations
Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations Open
Natural selection signatures across Japanese subpopulations are under-explored. Here we conducted genome-wide selection scans with 622,926 single nucleotide polymorphisms for 20,366 Japanese individuals, who were recruited from the main-is…
View article: Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects Open
View article: Population-specific reference panel improves imputation quality and enhances locus discovery and fine-mapping
Population-specific reference panel improves imputation quality and enhances locus discovery and fine-mapping Open
In order to improve the imputation quality for genome-wide association studies (GWAS) conducted on the Japanese population, we created and assessed four Japanese population-specific reference panels. These reference panels were generated u…
View article: Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH
Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH Open
View article: Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Open
View article: Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals Open
View article: Genetic insights into biological mechanisms governing human ovarian ageing
Genetic insights into biological mechanisms governing human ovarian ageing Open
View article: Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes
Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes Open
View article: The trans-ancestral genomic architecture of glycemic traits.
The trans-ancestral genomic architecture of glycemic traits. Open
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association stud…
View article: The trans-ancestral genomic architecture of glycemic traits
The trans-ancestral genomic architecture of glycemic traits Open
View article: Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes
Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes Open
Several reports have suggested that genetic susceptibility contributes to the development and progression of diabetic retinopathy. We aimed to identify genetic loci that confer susceptibility to diabetic retinopathy in Japanese patients wi…
View article: Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Open
View article: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Open
View article: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism Open
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies identified a variant in the ADCY5 gene…
View article: Genome-wide meta-analysis of common variant differences between men and women
Genome-wide meta-analysis of common variant differences between men and women Open
The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological …
View article: Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits Open
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide as…
View article: Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Open
We assembled an ancestrally diverse collection of genome-wide association studies of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). We identified 277 loci at genome-wide significance ( p <5×10 -…
View article: The Trans-Ancestral Genomic Architecture of Glycaemic Traits
The Trans-Ancestral Genomic Architecture of Glycaemic Traits Open
Glycaemic traits are used to diagnose and monitor type 2 diabetes, and cardiometabolic health. To date, most genetic studies of glycaemic traits have focused on individuals of European ancestry. Here, we aggregated genome-wide association …
View article: Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer Open