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View article: Frailty, Physical Function Impairment and Pulmonary Function in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS)
Frailty, Physical Function Impairment and Pulmonary Function in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS) Open
Background People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairment…
View article: Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study
Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study Open
People living with HIV have greater pulmonary function impairments and decreased health-related quality of life (HRQoL) compared to uninfected peers. We examined whether pulmonary impairment was associated with HRQoL or respiratory health …
View article: Regional Differences in Risk of Recurrent Falls Among Older U.S. Women and Men with HIV in the HIV Infection, Aging, and Immune Function Long-Term Observational Study
Regional Differences in Risk of Recurrent Falls Among Older U.S. Women and Men with HIV in the HIV Infection, Aging, and Immune Function Long-Term Observational Study Open
Geographic location was a strong predictor of falls among women with and without HIV in the Women's Interagency HIV Study. We examined regional variation in falls in a more geographically diverse cohort of older people with HIV (PWH) and e…
View article: Impact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic
Impact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic Open
Background: More than 80% of antibiotics are prescribed in the outpatient setting, of which 30% are inappropriate. The National Action Plan for Combating Antimicrobial Resistance called for a 50% decrease in outpatient antibiotic use by 20…
View article: Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study
Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study Open
We sought to determine effects of age, HIV serostatus, and smoking on the associations between pulmonary function and physical function impairments using Multicenter AIDS Cohort Study data. Associations between physical function outcomes g…
View article: Risk Factors for Hospitalization in People With HIV and COVID-19
Risk Factors for Hospitalization in People With HIV and COVID-19 Open
Kamis, Kevin F. MPH; Barbera, Lauren MD(c); Abdo, Mona PhD(c); Rowan, Sarah E. MD; Hussain, Cory MD; Gardner, Edward M. MD; Johnson, Steven C. MD; MaWhinney, Samantha ScD; Davis, Amelia J. MD; Carlson, Jesse MPH(c); Kozacka, Katie A. MD; E…
View article: A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study
A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study Open
Impairments in physical function and increased systemic levels of inflammation have been observed in middle-aged and older persons with HIV (PWH). We previously demonstrated that in older persons, associations between gut microbiota and in…
View article: Associations Between Tenofovir Diphosphate in Dried Blood Spots, Impaired Physical Function, and Fracture Risk
Associations Between Tenofovir Diphosphate in Dried Blood Spots, Impaired Physical Function, and Fracture Risk Open
Background In this study, we evaluate associations between cumulative antiretroviral adherence/exposure, quantified using tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), and human immunodeficiency virus (HIV)-related aging facto…
View article: Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study
Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study Open
Background: The longer-term risks of statins on physical function among people with HIV are unclear. Methods: Longitudinal analysis of Multicenter AIDS Cohort Study men between 40 and 75 years of age with ≥2 measures of gait speed or grip …
View article: Physical Function and Frailty Tools in Mortality Prediction of Middle-Aged Adults With HIV
Physical Function and Frailty Tools in Mortality Prediction of Middle-Aged Adults With HIV Open
Background: Frailty and physical function impairments occur at an earlier than expected age in people with HIV (PWH). The goal of this study was to determine which tools or combination of tools assessing frailty/physical function were most…
View article: End-of-Life Planning Prior to Death Among People Living With HIV
End-of-Life Planning Prior to Death Among People Living With HIV Open
People with HIV (PWH) often experience social isolation, loss of friends or partners, and estranged family relationships, creating challenges in selecting medical decision makers or clarifying end-of-life wishes. Whether advanced directive…
View article: Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015
Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015 Open
Colorado is regularly impacted by long-range transport of wildfire smoke from upwind regions. This smoke is a major source of ambient PM2.5. Maternal exposure to total PM2.5 during pregnancy has been linked to decreased birth weight and ot…
View article: Examining Mortality to Identify Opportunities for Improved Care Among Adults with HIV in a Single Academic Medical Center
Examining Mortality to Identify Opportunities for Improved Care Among Adults with HIV in a Single Academic Medical Center Open
Mortality for people living with HIV (PLWH) has dramatically decreased since the mid-1990s and the proportion of deaths attributable to non-AIDS-related conditions has increased. Deceased PLWH were identified from a single academic medical…
View article: 2244. Non-AIDS Cancers Contribute to an Increasing Proportion of Deaths in Persons Living with HIV at a Single University-Based Clinic
2244. Non-AIDS Cancers Contribute to an Increasing Proportion of Deaths in Persons Living with HIV at a Single University-Based Clinic Open
BACKGROUND: Mortality for people living with HIV (PLWH) has drastically decreased since the mid-1990s, and the proportion of deaths due to non-HIV-related conditions has increased. METHODS: Deceased PLWH were identified within a single aca…
View article: Frailty, Neurocognitive Impairment, or Both in Predicting Poor Health Outcomes Among Adults Living With Human Immunodeficiency Virus
Frailty, Neurocognitive Impairment, or Both in Predicting Poor Health Outcomes Among Adults Living With Human Immunodeficiency Virus Open
The presence of frailty with NCI was associated with a greater risk of falls, disability, or death in PLWH than NCI alone. Interventions that target prevention or reversal of both frailty and NCI (such as increased physical activity) may s…
View article: Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults
Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults Open
Aging HIV-infected prefrail and frail individuals are at significantly increased risk of falls. Incorporation of frailty assessments or simple evaluations of walk speed or grip strength in clinical care may help identify individuals at gre…