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View article: The CRISPR‒Cas9 system for genome editing of the ASS1 gene in human cells to predict its effect on HSV-1 replication
The CRISPR‒Cas9 system for genome editing of the ASS1 gene in human cells to predict its effect on HSV-1 replication Open
Herpes simplex virus type 1 (HSV-1) is a highly contagious pathogen that establishes lifelong latent infections. The replication of HSV-1 is potentially influenced by the arginine succinate synthase (ASS1) gene, a key regulator of cellular…
View article: Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran
Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran Open
Acinetobacter baumannii (A. baumannii) is a prevalent infectious agent regularly reported from hospital intensive care unit (ICU) patients. Annually, Multi-drug-resistant (MDR) isolates present a significant clinical challenge. The present…
View article: Co-infection of SARS-CoV-2 and Influenza A: a report from in Southwestern Iran
Co-infection of SARS-CoV-2 and Influenza A: a report from in Southwestern Iran Open
Background Since December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in China, and quickly spread worldwide. To date, SARS-CoV-2 infection has become a global co…
View article: The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population
The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population Open
Background Variations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell (NK) function is regulated by sophisticated receptor system including Killer-cell immunoglob…
View article: Targeting Host Calcium Channels and Viroporins: A Promising Strategy for SARS-CoV-2 Therapy
Targeting Host Calcium Channels and Viroporins: A Promising Strategy for SARS-CoV-2 Therapy Open
Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca2+ is required to enhance…
View article: Two Oncoviruses of HPV and EBV in Breast Cancer: An Iran-based Study
Two Oncoviruses of HPV and EBV in Breast Cancer: An Iran-based Study Open
OBJECTIVE: To answer the question of whether viral infections such as Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are involved in the occurrence of breast cancer or not. METHODOLOGY: In this case-control study, 50 paraffin-embe…
View article: The role of SARS-CoV-2 accessory proteins in immune evasion
The role of SARS-CoV-2 accessory proteins in immune evasion Open
View article: Seroprevalence of TORCH Syndrome Among Women of Reproductive Age in Mashhad, Northeast of Iran
Seroprevalence of TORCH Syndrome Among Women of Reproductive Age in Mashhad, Northeast of Iran Open
Aims TORCH syndrome is responsible for 2% to 3% of all congenital anomalies caused by Toxoplasma gondii (T. gondii), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV). The current study aims to determine the prevale…
View article: CRISPR-Cas System: A Promising Diagnostic Tool for Covid-19
CRISPR-Cas System: A Promising Diagnostic Tool for Covid-19 Open
More than a year has passed since the beginning of the 2019 novel coronavirus diseases (COVID-19) pandemic which has created massive problems globally affecting all aspects of people's life. Due to the emergence of new strains of the SARS-…
View article: Target genes used for biosensor development in COVID-19 diagnosis
Target genes used for biosensor development in COVID-19 diagnosis Open
View article: Seroprevalence of Toxoplasma gondii, Rubella and Cytomegalovirus Among Women of Reproductive Age in Mashhad, Northeast of Iran
Seroprevalence of Toxoplasma gondii, Rubella and Cytomegalovirus Among Women of Reproductive Age in Mashhad, Northeast of Iran Open
Purpose: TORCH syndrome is responsible for 2-3% of all congenital anomalies caused by Toxoplasma gondii (T. gondii) , Rubella virus (RV) , Cytomegalovirus (CMV) , and Herpes simplex virus (HSV). The current study aimed to determine the pre…
View article: Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children
Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children Open
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as ot…
View article: The Role of miRNAs in COVID-19 Disease
The Role of miRNAs in COVID-19 Disease Open
Nowadays, the SARS Coronavirus 2 (SARS-CoV-2) infection is recognized as the primary cause of mortality in humans. SARS-CoV-2 is transmitted through human-to-human contact and is asymptomatic in most patients. In addition to approved vacci…
View article: Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics
Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics Open
According to the evidence, the coronavirus disease 19 (COVID‐19) is caused by a zoonotic pathogen named respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This virus can spread through personal contact, respiratory droplets, and also through…
View article: A knockdown of the herpes simplex virus type-1 gene in all-in-one CRISPR vectors
A knockdown of the herpes simplex virus type-1 gene in all-in-one CRISPR vectors Open
The pCas-Guide-EF1a-GFP CRISPR vector can create a fast and efficient method for gRNA cloning by restriction enzymes (Esp3I (BsmBI) and BamHI). Therefore, the CRISPR/Cas9 system may be utilized for the screening of genes critical for the H…
View article: Comparison of the COVID-2019 (SARS-CoV-2) Pathogenesis With SARS-CoV and MERS-CoV Infections
Comparison of the COVID-2019 (SARS-CoV-2) Pathogenesis With SARS-CoV and MERS-CoV Infections Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in several patients who traveled to Wuhan or went to a seafood wholesale market in Wuhan. The phylogenetic tree showed that SARS-CoV-2 was 96.2% identic…
View article: Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay
Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay Open