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View article: Effects of <em>Sutherlandia Frutescens</em> on Cancer and Primary Cells during Chemotherapy and Chemotherapy Induced Cellular Senescence
Effects of <em>Sutherlandia Frutescens</em> on Cancer and Primary Cells during Chemotherapy and Chemotherapy Induced Cellular Senescence Open
Background/Objectives: Cancer is a global health problem. Chemotherapeutics such as 5-fluorouracil and etoposide are important but limited by side effects and resistance. Cel-lular senescence can both suppress and promote tumors through th…
View article: Parameter Optimization and Capacitance-Based Monitoring of In Situ Cell Detachment in Microcarrier Cultures
Parameter Optimization and Capacitance-Based Monitoring of In Situ Cell Detachment in Microcarrier Cultures Open
This study delves into the scale-down optimization of the in situ cell detachment process for MA 104 cells cultivated on Cytodex 1 microcarriers (MCs). Through a systematic exploration, critical operational parameters—the agitation speed, …
View article: Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling
Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling Open
Microcarrier-based cell culture is a commonly used method to facilitate the growth of anchorage-dependent cells like MA 104 for antigen manufacturing. However, conventionally, static cell culture is employed for cell propagation before see…