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View article: Comparative study between opioid usage and opioid free anesthesia in laparoscopic bariatric surgeries
Comparative study between opioid usage and opioid free anesthesia in laparoscopic bariatric surgeries Open
Background & objective: The number of bariatric surgeries is rapidly increasing the world over, and the concept of fast-track surgery using laparoscopy has made bariatric surgeries a cost-effective and efficient way of treating morbidly ob…
View article: In vitro localization of modified zinc oxide nanoparticles showing selective anticancer effects against colorectal carcinoma using biophysical techniques
In vitro localization of modified zinc oxide nanoparticles showing selective anticancer effects against colorectal carcinoma using biophysical techniques Open
In recent decades, despite advancements in conventional cancer therapies, their serious side effects on both healthy and tumor cells remain a major concern. Aiming to address indiscriminate drug distribution, unwanted toxicity, and high ch…
View article: MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells
MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells Open
Introduction The role of miRNAs in regulating variable molecular functions has been sought by scientists for its promising utility in regulating the immune response and, hence, in treating various diseases. In hepatocellular carcinoma (HCC…
View article: The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients
The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients Open
Introduction COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage…
View article: Evidence associating neutrophilia, lung damage, hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality in critically ill COVID-19 patients
Evidence associating neutrophilia, lung damage, hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality in critically ill COVID-19 patients Open
Background COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis. Since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes and that …
View article: Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients
Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients Open
Roles of platelets during infections surpass the classical thrombus function and are now known to modulate innate immune cells. Leukocyte-platelet aggregations and activation-induced secretome are among factors recently gaining interest bu…
View article: Author response: Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality
Author response: Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Human serum albumin (H…
View article: Neutrophil-mediated Oxidative Stress and Albumin Structural Damage Predict COVID-19-associated Mortality
Neutrophil-mediated Oxidative Stress and Albumin Structural Damage Predict COVID-19-associated Mortality Open
Human serum albumin (HSA) is the frontline antioxidant protein in blood with established anti-inflammatory and anticoagulation functions. Here we report that COVID-19-induced oxidative stress inflicts structural damages to HSA and is linke…