Mario Castro
YOU?
Author Swipe
View article: Using hyperpolarized <sup>129</sup> Xe MRI to investigate longitudinal effects of long COVID on pulmonary function
Using hyperpolarized <sup>129</sup> Xe MRI to investigate longitudinal effects of long COVID on pulmonary function Open
View article: Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART)
Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART) Open
View article: Effect of Dupilumab on Mucus Burden in Patients with Moderate-to-Severe Asthma: The VESTIGE Trial
Effect of Dupilumab on Mucus Burden in Patients with Moderate-to-Severe Asthma: The VESTIGE Trial Open
gov, ID: NCT04400318.
View article: Metformin on the Presence of COVID-19 Symptoms Over 6 Months: The ACTIV-6 Randomized Clinical Trial
Metformin on the Presence of COVID-19 Symptoms Over 6 Months: The ACTIV-6 Randomized Clinical Trial Open
Background: The effect of metformin on preventing long-term COVID-19 symptoms among low-risk adults has not been studied. The objective of this study was to Assess metformin compared with placebo during acute SARS-CoV-2 infection on the pr…
View article: The role of family control and ownership in M&A decisions: Evidence from an emerging market
The role of family control and ownership in M&A decisions: Evidence from an emerging market Open
View article: New Advances in Asthma Care: Improving Management and Outcomes
New Advances in Asthma Care: Improving Management and Outcomes Open
View article: Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium Open
View article: 1373 Understanding Knowledge, Attitudes, and Skills of Hospitalists’ Care of the Patient with OSA
1373 Understanding Knowledge, Attitudes, and Skills of Hospitalists’ Care of the Patient with OSA Open
Introduction An estimated 24 million people in the United States (U.S.) have undiagnosed obstructive sleep apnea (OSA). Untreated OSA is associated with an increased risk of multiple health conditions including atrial fibrillation, hyperte…
View article: Differences in COPD management across clinician type: Maintenance treatment habits and patient characteristics among US pulmonologists, internal/family medicine physicians, nurse practitioners, and physician assistants
Differences in COPD management across clinician type: Maintenance treatment habits and patient characteristics among US pulmonologists, internal/family medicine physicians, nurse practitioners, and physician assistants Open
Objectives Treatment recommendations for chronic obstructive pulmonary disease (COPD) are based on single or combination long-acting bronchodilator therapy (β 2 -agonists [LABAs] or muscarinic receptor antagonists [LAMAs]), with inhaled co…
View article: Design and Implementation of a Multi‐Center Trial of <scp> <sup>129</sup> Xe </scp> Gas Exchange <scp>MRI</scp> and <scp>MRS</scp> to Evaluate Longitudinal Progression of <scp>COPD</scp>
Design and Implementation of a Multi‐Center Trial of <span> <sup>129</sup> Xe </span> Gas Exchange <span>MRI</span> and <span>MRS</span> to Evaluate Longitudinal Progression of <span>COPD</span> Open
MR imaging holds the potential to enhance drug development efficiency by de‐risking early phase studies and increasing confidence in results. It can improve patient selection, increase repeatability, and provide greater sensitivity to chan…
View article: Efficacy of Biologics in Reducing Exacerbations Requiring Hospitalization or an Emergency Department Visit in Patients with Moderate or Severe, Uncontrolled Asthma
Efficacy of Biologics in Reducing Exacerbations Requiring Hospitalization or an Emergency Department Visit in Patients with Moderate or Severe, Uncontrolled Asthma Open
View article: Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials
Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials Open
View article: Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ)
Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ) Open
View article: Oxidative Stress Pathway Genotypes Interact with Environmental Pollutant Levels to Influence Gene Expression and Lung Function
Oxidative Stress Pathway Genotypes Interact with Environmental Pollutant Levels to Influence Gene Expression and Lung Function Open
View article: New frontiers in asthma chest imaging
New frontiers in asthma chest imaging Open
Modern pulmonary imaging can reveal underlying pathologic and pathophysiologic changes in the lungs of people with asthma, with important clinical implications. A multitude of imaging modalities, including computed tomography, magnetic res…
View article: 2024 Update of the RECOVER-Adult Long COVID Research Index
2024 Update of the RECOVER-Adult Long COVID Research Index Open
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate n…
View article: Circulating microRNAs associated with bronchodilator response in childhood asthma
Circulating microRNAs associated with bronchodilator response in childhood asthma Open
View article: Cardio Policy Optimiser: an integrated public health approach to enhancing cardiovascular health
Cardio Policy Optimiser: an integrated public health approach to enhancing cardiovascular health Open
Background Cardiovascular diseases (CVDs) remain a leading cause of mortality in Europe, with atherosclerotic-related conditions accounting for 80% of CVD deaths - a third of them premature. Despite extensive efforts over the past five dec…
View article: Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo
Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo Open
Importance The effect of montelukast in reducing symptom duration among outpatients with mild to moderate COVID-19 is uncertain. Objective To assess the effectiveness of montelukast compared with placebo in treating outpatients with mild t…
View article: CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant
CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant Open
Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institute…
View article: Airways Abnormalities in a Prospective Cohort of Patients With Rheumatoid Arthritis
Airways Abnormalities in a Prospective Cohort of Patients With Rheumatoid Arthritis Open
View article: Clinical response and on-treatment clinical remission with tezepelumab in a broad population of patients with severe, uncontrolled asthma: results over 2 years from the NAVIGATOR and DESTINATION studies
Clinical response and on-treatment clinical remission with tezepelumab in a broad population of patients with severe, uncontrolled asthma: results over 2 years from the NAVIGATOR and DESTINATION studies Open
Background In asthma, clinical response is characterised by disease improvement with treatment, whereas clinical remission is characterised by long-term disease stabilisation with or without ongoing treatment. The proportions of patients r…
View article: Uncovering patterns of inhaler technique and reliever use: the value of objective, personalized data from a digital inhaler
Uncovering patterns of inhaler technique and reliever use: the value of objective, personalized data from a digital inhaler Open
View article: Impact of nebulization versus metered-dose inhaler utilization on viral particle dispersion in patients with COVID-19
Impact of nebulization versus metered-dose inhaler utilization on viral particle dispersion in patients with COVID-19 Open
Background Conflicting guidance exists regarding the characterization of nebulization as an aerosol-generating procedure and subsequent risk of transmission of SARS-CoV-2 to healthcare workers. Aim/Objective This study sought to address wh…
View article: Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division
Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division Open
Division and differentiation events by which cell populations with specific functions are generated often take place as part of a developmental programme, which can be represented by a sequence of compartments. A compartment is the set of …
View article: iPREDICT: Characterization of Asthma Triggers and Selection of Digital Technology to Predict Changes in Disease Control
iPREDICT: Characterization of Asthma Triggers and Selection of Digital Technology to Predict Changes in Disease Control Open
These findings emphasize the need to systematically compare devices based on several parameters, including usability and data quality, to develop integrated digital technology programs for asthma care.
View article: Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease
Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease Open
Background Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic challenges due to their heterogeneous nature. This study ai…
View article: Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction
Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction Open
Background Persistent airflow obstruction (PAO) in patients with asthma can be difficult to treat. Tezepelumab blocks thymic stromal lymphopoietin, an epithelial cytokine implicated in asthma pathogenesis. This analysis evaluated the effic…
View article: Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13–stimulated airway epithelial cells
Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13–stimulated airway epithelial cells Open
Mucus plugs occlude airways to obstruct airflow in asthma. Studies in patients and in mouse models show that mucus plugs occur in the context of type 2 inflammation, and studies in human airway epithelial cells (HAECs) show that IL-13-acti…
View article: Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease
Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease Open
Background Idiopathic interstitial pneumonias (IIPs) such as idiopathic pulmonary fibrosis (IPF) and interstitial pneumonia with autoimmune features (IPAF), present diagnostic and therapeutic challenges due to their heterogeneous nature. T…