Moni Nader
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Improving T2D machine learning-based prediction accuracy with SNPs and younger age Open
While traditional clinical factors remained the strongest predictors of T2D risk, integration of genomic data produced a modest improvement in model performance, especially among younger adults. Validation across independent datasets confi…
PHACTR1 and APOC1 genetic variants are associated with multi-vessel coronary artery disease Open
Following replication of the associations in the large UK Biobank dataset, it was found that patients carrying the rs9349379*G variant in the PHACTR1 gene are at risk of developing severe or multivessel disease. Conversely, the rs445925*T …
HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults Open
Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults. Methods A to…
Rapid, label-free, contactless measurement of membrane potential in excitable H9c2 cardiomyoblasts using ζ-potential Open
The measurement of cell membrane potential ( V m ) is important for understanding ion channel function. V m plays a role in several routine cellular functions and diseases, particularly in excitable cells such as muscle and nerve. However,…
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy Open
Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the vasculature. Attenuation of this pathological remodeling of blood vessels remains an unmet t…
View article: Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern
Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern Open
EDITORIAL article Front. Physiol., 11 July 2023Sec. Clinical and Translational Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1224550
View article: The impact of forced displacement: trauma, increased levels of inflammation and early presentation of diabetes in women Syrian refugees
The impact of forced displacement: trauma, increased levels of inflammation and early presentation of diabetes in women Syrian refugees Open
Background Forced displacement and war trauma cause high rates of post-traumatic stress, anxiety disorders and depression in refugee populations. We investigated the impact of forced displacement on mental health status, gender, presentati…
Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients Open
The rs9349379 in PHACTR1 gene is significantly associated with restenosis, this association is more pronounced in women and in diabetic patients. The rs264 in LPL gene was associated with increased risk of restenosis in male patients.
View article: Elevated Lp(a) Levels Correlate with Severe and Multiple Coronary Artery Stenotic Lesions
Elevated Lp(a) Levels Correlate with Severe and Multiple Coronary Artery Stenotic Lesions Open
Cynthia Al Hageh,1,* Stephanie Chacar,2,* Michella Ghassibe-Sabbagh,3 Daniel E Platt,4 Andreas Henschel,5 Hamdan Hamdan,2 Dominique Gauguier,6,7 Yara El Murr,3 Eman Alefishat,8,9 Elie Chammas,10 Siobhn OSullivan,1 Antoine Abchee,11 Moni Na…
View article: Observational study of factors associated with morbidity and mortality from COVID-19 in Lebanon, 2020–2021
Observational study of factors associated with morbidity and mortality from COVID-19 in Lebanon, 2020–2021 Open
Background The COVID-19 pandemic claimed millions of lives worldwide without clear signs of abating despite several mitigation efforts and vaccination campaigns. There have been tremendous interests in understanding the etiology of the dis…
Morning exercise improves sleep quality in university students Open
Background: Although sleep is influenced by exercise, a proper management of physical activity’s time promotes the quality of sleep. The objective of this study was to evaluate, in university students, the effect of morning or evening phys…
Structural and Electrical Remodeling of the Sinoatrial Node in Diabetes: New Dimensions and Perspectives Open
The sinoatrial node (SAN) is composed of highly specialized cells that mandate the spontaneous beating of the heart through self-generation of an action potential (AP). Despite this automaticity, the SAN is under the modulation of the auto…
View article: Creatinine levels on admission are main modulators of COVID-19 severity
Creatinine levels on admission are main modulators of COVID-19 severity Open
Background: The COVID-19 pandemic claimed millions of lives worldwide without clear signs of abating. There have been tremendous interests in understanding the etiology of the disease particularly in what makes it fatal in certain patients…
Striatin translocates to the cytosol of apoptotic cells and is proteolytically cleaved in a caspase 3-dependent manner Open
Striatin (STRN) is a multivalent protein holding great therapeutic potentials in view of its interaction with dynamic partners implicated in apoptosis. Although striatin-3 and striatin-4, that share high structural similarities with STRN, …
Natural Antioxidants and Vitamins Supplementation Shelters Adolescents from Upper Respiratory Tract Infection Open
Context: Several decades of dietary research recommended the consumption of antioxidants and vitamins rich foods as a protective tool against a broad portfolio of diseases Aims: This study aims to test if oral supplementation of natural an…
Cardiac striatin interacts with caveolin-3 and calmodulin in a calcium sensitive manner and regulates cardiomyocyte spontaneous contraction rate Open
Impaired cardiomyocyte contraction rate is detrimental to cardiac function and often lethal. Despite advancements in the field, there is a paucity of information regarding the coordination of molecules implicated in regulating the heart ra…