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Correction: Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study Open

Liye Lai, Dave Laurence Juntilla, Monica Del C. Gomez-Alonso, Harald Grallert, Barbara Thorand , et al. · 2025

Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study Open

Liye Lai, Dave Laurence Juntilla, M Shad Del, Monica Del C. Gomez-Alonso, Harald Grallert , et al. · 2025

Background Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methylation comes from cro…

Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study Open

Mohamed A. Elhadad, Monica Del C. Gomez-Alonso, Chien‐Wei Chen, Sonja Neumeyer, Thomas Delerue , et al. · 2024

Plasma Proteome Association with Coronary Heart Disease and Carotid Intima Media Thickness: results from the KORA F4 study Open

Mohamed A. Elhadad, Monica Del C. Gomez-Alonso, Chien‐Wei Chen, Sonja Neumeyer, Thomas Delerue , et al. · 2023

Background and aims: Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mecha…

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Background The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation and the lipid composi…

Additional file 19 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 19: Table S14. Inflation factors for each epigenome-wide association analysis. Presented are the genomic inflation factors (lambda) for all 226 EWAS run in the discovery analysis in KORA F4. All inflation factors were calcu…

Additional file 10 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 10: Table S6. Results of look-ups in two epigenome-wide association study (EWAS) catalogues, the EWAS Atlas [39] (Source: “EWAS_Atlas”) and the EWAS Catalog [40] (Source: “EWAS_Cat”). Shown are the catalogue results (signif…

Additional file 12 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 12: Table S8. Results of gene expression analysis of CpG sites associated with metabolic measures. Displayed are the FDR (Benjamini-Hochberg, < 0.05) statistically significant associations between metabolic measure-associat…

Additional file 1 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 1: Table S1. List of the metabolic measures (N = 228) assessed in all cohorts.

Additional file 3 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 3: Table S3. Summary statistics comparing the 274 KORA-significant associations across the replication cohorts. Results are given as total number (proportion) or as p values calculated using the binomial distribution (n = n…

Additional file 5 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 5: Table S4. Replication tables. Replicated associations are displayed by CpG site, CpG gene location, metabolite (metabolic measure), and metabolite type (metabolic measure type). A total of 274 significant, robust associa…

Additional file 13 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 13: Table S9. Results of the sex interaction analysis. Results for all 148 replication CpG site-metabolic measure associations are shown for models identical to the discovery, but with additional “sex × methylation” interac…

Additional file 17 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 17: Table S13. ROC curve analysis for significant CpG-outcome associations: Presented are the areas under the curve (AUC) for the receiver operating characteristic (ROC) curve analysis for each outcome-CpG pair for which th…

Additional file 15 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 15: Table S11. Results of the associations between CpG sites and expression of transcripts of genes codifying for enzymes or proteins directly involved with lipoprotein metabolism. Results are shown for those pairs passing …

Additional file 11 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 11: Table S7. Genetically influenced CpG site-metabolic measure associations. Results for the cis-SNP analysis are presented. “Coef_discovery” and “P_discovery”: coefficient and p value for the discovery analysis for the gi…

Additional file 16 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 16: Table S12. Results of the investigation into associations between metabolic measures-related CpG sites and clinical outcomes. Listed are the CpG site-clinical outcome (previous myocardial infarction, prevalent type 2 di…

Additional file 14 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 14: Table S10. Results of the associations with additional metabolic measure ratios as proxies of enzymatic activity or linked to metabolic disease. Results for all 12 replicated metabolic measure-associated CpG sites assoc…

Additional file 2 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 2: Table S2. Epigenome-wide association study (EWAS) of metabolic measures. Presented are CpG site-metabolic measurement pairs statistically significantly associated in the KORA F4 discovery study. Results for the discovery…

Additional file 9 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures Open

Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen , et al. · 2021

Additional file 9: Table S5. Results of the EWAS of metabolite measure principal components. Presented are the statistically significant (Bonferroni-adjusted P < 1.34e−8) results of the EWAS of the first 8 principal components of the metab…

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