Monica Mangoni
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View article: A gap analysis integrating In vitro - Research in HDR interventional radiotherapy (Modern Brachytherapy): Challenges, limitations, and future directions
A gap analysis integrating In vitro - Research in HDR interventional radiotherapy (Modern Brachytherapy): Challenges, limitations, and future directions Open
View article: Use and utility of endocrine multidisciplinary tumour board: an appraisal from a tertiary centre
Use and utility of endocrine multidisciplinary tumour board: an appraisal from a tertiary centre Open
Introduction The Endocrine Multidisciplinary Tumour Board (EMTB) is a specialised board for endocrine tumours, including thyroid, adrenal, and rare endocrine neoplasms. Although required by major guidelines, little is known about the curre…
View article: Fluorescent Deferoxamine Complexes of Cu(II) and Zr(IV): Insights in the Development of Dual Imaging Probes
Fluorescent Deferoxamine Complexes of Cu(II) and Zr(IV): Insights in the Development of Dual Imaging Probes Open
Deferoxamine (DFO) is widely regarded as benchmark chelator for 89 Zr(IV), a commonly used PET (positron emission tomography) tracer. We have introduced a novel fluorescent coumarin derivative of DFO (DFOKC), characterized by chelating uni…
View article: Patient Positioning and Treatment Techniques in Total Skin Irradiation: A Scoping Review
Patient Positioning and Treatment Techniques in Total Skin Irradiation: A Scoping Review Open
Introduction: Total skin irradiation (TSI) is a radiotherapy technique used to treat cutaneous lymphomas, such as mycosis fungoides. A key aspect of the success of the treatment is the correct positioning of the patient, which ensures a ho…
View article: Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients Open
View article: The Role of Stereotactic Radiotherapy in Deferring the Need for Systemic Therapies in Patients with Progressive Oligometastatic Iodine-Refractory Thyroid Cancer
The Role of Stereotactic Radiotherapy in Deferring the Need for Systemic Therapies in Patients with Progressive Oligometastatic Iodine-Refractory Thyroid Cancer Open
View article: Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO)
Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO) Open
PURPOSE ARTO (ClinicalTrials.gov identifier: NCT03449719 ) is a multicenter, phase II randomized clinical trial testing the benefit of adding stereotactic body radiation therapy (SBRT) to abiraterone acetate and prednisone (AAP) in patient…
View article: Desensitization Protocol for Cemiplimab-Related Infusion Reaction in Cutaneous Squamous Cell Carcinoma: A Case Report and Literature Review
Desensitization Protocol for Cemiplimab-Related Infusion Reaction in Cutaneous Squamous Cell Carcinoma: A Case Report and Literature Review Open
Background: The landscape of systemic therapies for advanced non-melanoma skin cancers has been revolutionized by the advent of immunotherapy. Cemiplimab is the only immune checkpoint inhibitor (ICI) approved by the European Medicine Agenc…
View article: Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review
Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review Open
View article: Evaluation of coumarin-tagged deferoxamine as a Zr(IV)-based PET/fluorescence dual imaging probe
Evaluation of coumarin-tagged deferoxamine as a Zr(IV)-based PET/fluorescence dual imaging probe Open
View article: Radiosensitizing Effect of Trabectedin on Human Soft Tissue Sarcoma Cells
Radiosensitizing Effect of Trabectedin on Human Soft Tissue Sarcoma Cells Open
Trabectedin is used for the treatment of advanced soft tissue sarcomas (STSs). In this study, we evaluated if trabectedin could enhance the efficacy of irradiation (IR) by increasing the intrinsic cell radiosensitivity and modulating tumor…
View article: Preoperative robotic radiosurgery for early breast cancer: Results of the phase II ROCK trial (NCT03520894)
Preoperative robotic radiosurgery for early breast cancer: Results of the phase II ROCK trial (NCT03520894) Open
View article: Study protocol and preliminary results from a mono-centric cohort within a trial testing stereotactic body radiotherapy and abiraterone (ARTO-NCT03449719)
Study protocol and preliminary results from a mono-centric cohort within a trial testing stereotactic body radiotherapy and abiraterone (ARTO-NCT03449719) Open
Background ARTO trial was designed to evaluate the difference in terms of outcomes between patients affected by oligo metastatic castrate resistant prostate cancer (mCRPC) treated with Abiraterone acetate and randomized to receive or not S…
View article: Prospective assessment of AR splice variant and multi-biomarker expression on circulating tumor cells of mCRPC patients undergoing androgen receptor targeted agents: interim analysis of PRIMERA trial (NCT04188275)
Prospective assessment of AR splice variant and multi-biomarker expression on circulating tumor cells of mCRPC patients undergoing androgen receptor targeted agents: interim analysis of PRIMERA trial (NCT04188275) Open
View article: The role of stereotactic radiotherapy in addition to immunotherapy in the management of melanoma brain metastases: results of a systematic review
The role of stereotactic radiotherapy in addition to immunotherapy in the management of melanoma brain metastases: results of a systematic review Open
View article: Contents
Contents Open
View article: Olive phenols preserve lamin B1 expression reducing cGAS/STING/NFκB‐mediated SASP in ionizing radiation‐induced senescence
Olive phenols preserve lamin B1 expression reducing cGAS/STING/NFκB‐mediated SASP in ionizing radiation‐induced senescence Open
Senescence occurs upon critical telomere shortening, or following DNA damage, oncogenic activation, hypoxia and oxidative stress, overall referred to stress‐induced premature senescence (SIPS). In response to DNA damage, senescent cells re…
View article: Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression
Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression Open
Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis when metastatic and scarce treatment options in the advanced stages. In solid tumors, the chemokine CXCL12/CXCR4 axis is involved in the metastatic process. We demonst…
View article: Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275)
Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275) Open
View article: Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review
Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review Open
Melanoma is an extremely aggressive tumor and is considered to be an extremely immunogenic tumor because compared to other cancers it usually presents a well-expressed lymphoid infiltration. The aim of this paper is to perform a multidisci…
View article: Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review
Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review Open
These data suggest that in adequately selected early-stage UPSC and UCCC patients, VIRt alone may be suitable in women who underwent surgical staging and received adjuvant chemotherapy. In early-stage UCS, a multidisciplinary therapeutic a…
View article: Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial
Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial Open
PURPOSE To report the long-term results of external-beam accelerated partial-breast irradiation (APBI) intensity-modulated radiation therapy (IMRT) Florence phase III trial comparing whole-breast irradiation (WBI) to APBI in early-stage br…
View article: Biomarkers in wound drainage fluids of head and neck squamous cell carcinoma patients receiving neck dissection: A pilot study
Biomarkers in wound drainage fluids of head and neck squamous cell carcinoma patients receiving neck dissection: A pilot study Open
Our pilot study showed that WDFs could qualify as a potential source of relevant postoperative information. Further studies are needed to confirm the prognostic impact of CXCL-12, Osteopontin and TGF-β expressed in WDFs on the personalized…
View article: Dosimetric Predictors of Acute and Chronic Alopecia in Primary Brain Cancer Patients Treated With Volumetric Modulated Arc Therapy
Dosimetric Predictors of Acute and Chronic Alopecia in Primary Brain Cancer Patients Treated With Volumetric Modulated Arc Therapy Open
Purpose: To determine dose constraints that correlate with alopecia in patients treated with photon-based Volumetric Modulated Arc Therapy (VMAT) for primary brain tumors. Methods: During the treatment planning process, the s…
View article: The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review
The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review Open
These data support the concept that in adequately selected patients, VBT alone may be a suitable radiotherapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.
View article: PO-0735: Low dose Total Skin Irradiation followed by maintenance with oral Bexarotene in Mycosis Fungoides
PO-0735: Low dose Total Skin Irradiation followed by maintenance with oral Bexarotene in Mycosis Fungoides Open
View article: Targeting <scp>LMW</scp>‐<scp>PTP</scp> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy
Targeting <span>LMW</span>‐<span>PTP</span> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy Open
Tumor resistance to apoptosis is one the main causes of anticancer treatment failure. Previous studies showed that LMW ‐ PTP overexpression enhances resistance of cancer cells to traditional anticancer drugs. Today, the role of LMW ‐ PTP i…
View article: Triple Negative Apocrine Carcinomas as a Distinct Subtype of Triple Negative Breast Cancer: A Case-control Study
Triple Negative Apocrine Carcinomas as a Distinct Subtype of Triple Negative Breast Cancer: A Case-control Study Open
View article: Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO)
Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO) Open
View article: EP-1350: Stereotactic re-irradiation for prostate cancer recurrence after upfront surgery and radiotherapy
EP-1350: Stereotactic re-irradiation for prostate cancer recurrence after upfront surgery and radiotherapy Open