Monica Monici
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View article: Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit
Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit Open
Human spaceflight is advancing toward sustainable exploration through initiatives like NASA's Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic r…
View article: Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions
Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions Open
Human space missions beyond Low Earth Orbit (LEO), such as to the Moon and Mars, will require increased crew autonomy in health management, due to communication delays and limited resupply. These missions pose unique biomedical challenges,…
View article: Multiwave Locked System Laser Treatment Reduces the Bacterial Load in the Gingival Sulcus of Dogs After Plaque Removal
Multiwave Locked System Laser Treatment Reduces the Bacterial Load in the Gingival Sulcus of Dogs After Plaque Removal Open
Periodontal disease is a prevalent condition in companion animals. It is crucial to prevent the plaque and bacteria on tooth surfaces to avoid gingivitis and the more harmful periodontitis. The aim of the present study was to assess the im…
View article: Laser Emission at 675 nm: Molecular Counteraction of the Aging Process
Laser Emission at 675 nm: Molecular Counteraction of the Aging Process Open
Background/Objectives: Many lasers applied in skin rejuvenation protocols show emissions with wavelengths falling in the red or near-infrared (NIR) bands. To obtain further in vitro data on the potential therapeutic benefits regarding reju…
View article: Author Correction: Hydrogel mechanical properties in altered gravity
Author Correction: Hydrogel mechanical properties in altered gravity Open
In this article the affiliation, “Department of Aerospace Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, UAE” for the author “Yarjan Abdul Samad” was inadvertently omitted. The original article has been correc…
View article: Hydrogel mechanical properties in altered gravity
Hydrogel mechanical properties in altered gravity Open
Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix in…
View article: Hydrogel Formulation for Biomimetic Fibroblast Cell Culture: Exploring Effects of External Stresses and Cellular Responses
Hydrogel Formulation for Biomimetic Fibroblast Cell Culture: Exploring Effects of External Stresses and Cellular Responses Open
In the process of tissue engineering, several types of stresses can influence the outcome of tissue regeneration. This outcome can be understood by designing hydrogels that mimic this process and studying how such hydrogel scaffolds and ce…
View article: Evaluation of the Impact of Near-Infrared Multiwavelength Locked System Laser Therapy on Skin Microbiome in Atopic Dogs
Evaluation of the Impact of Near-Infrared Multiwavelength Locked System Laser Therapy on Skin Microbiome in Atopic Dogs Open
Photobiomodulation (PBM) is a newly adopted consensus term to replace the therapeutic application of low-level laser therapy. It has been suggested that PMB influences the microbiome which, in turn, has increasingly been shown to be linked…
View article: Modeled microgravity unravels the roles of mechanical forces in renal progenitor cell physiology
Modeled microgravity unravels the roles of mechanical forces in renal progenitor cell physiology Open
Background The glomerulus is a highly complex system, composed of different interdependent cell types that are subjected to various mechanical stimuli. These stimuli regulate multiple cellular functions, and changes in these functions may …
View article: Editorial: Wound management and healing in space
Editorial: Wound management and healing in space Open
SCOPUS: ed.j
View article: Optimization of an Ex-Vivo Human Skin/Vein Model for Long-Term Wound Healing Studies: Ground Preparatory Activities for the ‘Suture in Space’ Experiment Onboard the International Space Station
Optimization of an Ex-Vivo Human Skin/Vein Model for Long-Term Wound Healing Studies: Ground Preparatory Activities for the ‘Suture in Space’ Experiment Onboard the International Space Station Open
This study is preliminary to an experiment to be performed onboard the International Space Station (ISS) and on Earth to investigate how low gravity influences the healing of sutured human skin and vein wounds. Its objective was to ascerta…
View article: Role of fibroblasts in wound healing and tissue remodeling on Earth and in space
Role of fibroblasts in wound healing and tissue remodeling on Earth and in space Open
Wound healing (WH) and the role fibroblasts play in the process, as well as healing impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We treat these topics briefly, with the only aim of contextualizing …
View article: Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing
Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing Open
During space flight, especially when prolonged, exposure to microgravity results in a number of pathophysiological changes such as bone loss, muscle atrophy, cardiovascular and metabolic changes and impaired wound healing, among others. In…
View article: Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions
Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions Open
Wound healing is slowed in Space. Microgravity and possible physical factors associated with Space affect alterations in fibroblast, matrix formation, dysregulation in apoptosis and inflammation. The microbial populations settled on skin, …
View article: Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature
Physiological adaptations affecting drug pharmacokinetics in space: what do we really know? A critical review of the literature Open
As human spaceflight progresses with extended mission durations, the demand for effective and safe drugs will necessarily increase. To date, the accepted medications used during missions (for space motion sickness, sleep disturbances, alle…
View article: Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices
Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices Open
The complexity of microglia phenotypes and their related functions compels the continuous study of microglia in diseases animal models. We demonstrated that oxygen-glucose deprivation (OGD) induced rapid, time- and space-dependent phenotyp…
View article: The Future of Personalized Medicine in Space: From Observations to Countermeasures
The Future of Personalized Medicine in Space: From Observations to Countermeasures Open
The aim of personalized medicine is to detach from a “one-size fits all approach” and improve patient health by individualization to achieve the best outcomes in disease prevention, diagnosis and treatment. Technological advances in sequen…
View article: Effect of Space Flight on the Behavior of Human Retinal Pigment Epithelial ARPE-19 Cells and Evaluation of Coenzyme Q10 Treatment
Effect of Space Flight on the Behavior of Human Retinal Pigment Epithelial ARPE-19 Cells and Evaluation of Coenzyme Q10 Treatment Open
Astronauts on board the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. One of the most critical and sensitive districts of their organism is the eye, and in particular the retina…
View article: The Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology
The Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology Open
Microgravity-induced bone loss is currently a significant and unresolved health risk for space travelers, as it raises the likelihood for irreversible changes that weaken skeletal integrity and the incremental onset of fracture injuries an…
View article: Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing
Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing Open
The fine control of inflammation following injury avoids fibrotic scars or impaired wounds. Due to side effects by anti-inflammatory drugs, the research is continuously active to define alternative therapies. Among them, physical counterme…
View article: Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial
Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial Open
Mariana A Vetrici,1,* Soheila Mokmeli,2,* Andrew R Bohm,3 Monica Monici,4 Scott A Sigman5,* 1Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada; 2Training Institute, Canadian Optic and Laser Center, Victori…
View article: Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial
Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial Open
PBMT is a safe and effective potential treatment for COVID-19 pneumonia and improves clinical status in COVID-19 pneumonia.
View article: Suture in Space: Preparation of an Experiment on the Healing of Sutured Wounds on Board the ISS
Suture in Space: Preparation of an Experiment on the Healing of Sutured Wounds on Board the ISS Open
Wound healing (WH) is a process strictly regulated and highly conserved throughout evolution because it is indispensable for surviving injuries. On Earth WH has been studied in depth, nevertheless the role of mechanical factors in regulati…
View article: A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19
A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19 Open
BACKGROUND Coronavirus disease 2019 (COVID-19) is associated with lung inflammation and cytokine storm. Photobiomodulation therapy (PBMT) is a safe, non-invasive therapy with significant anti-inflammatory effects. Adjunct PBMT has been emp…