Monica Sani
YOU?
Author Swipe
View article: Metabolite Profile and Ameliorative effects of Xeromphis nilotica on CCL4-induced Chemical Hepatitis. Using the Albino Mouse Model
Metabolite Profile and Ameliorative effects of Xeromphis nilotica on CCL4-induced Chemical Hepatitis. Using the Albino Mouse Model Open
Liver disease is on the upsurge with high mortality rate and the conventional treatment is associated with adverse side effect and exorbitant cost of treatment, there is thus a need for exploration of plant-based alternative. Xeromphis nil…
View article: Delivery of crocetin by grafting onto the surface of poly-aminopropylmethyl-silsesquioxane: Biocompatibility and wound healing ability assessment
Delivery of crocetin by grafting onto the surface of poly-aminopropylmethyl-silsesquioxane: Biocompatibility and wound healing ability assessment Open
View article: Metabolite Profile, Antioxidant Activity and Ameliorative Efficacy of Diospyros Mespiliformis on Carbon Tetrachloride (CCL4) Induced Oxidative-Stress in Albino Mice
Metabolite Profile, Antioxidant Activity and Ameliorative Efficacy of Diospyros Mespiliformis on Carbon Tetrachloride (CCL4) Induced Oxidative-Stress in Albino Mice Open
Liver diseases are deadly and requires continuous medication, conventional treatment is harmful and expensive, so there need for hepatoprotective remedy from plant sources. Bioactive phytochemicals were profiled and the efficacy of Diospyr…
View article: Hepatoprotective Effect of Ethanolic Extract of Rosemarinus officinalis (Rosemary) Leaves Against CCL4-induced Hepatic Damage in Albino Rats
Hepatoprotective Effect of Ethanolic Extract of Rosemarinus officinalis (Rosemary) Leaves Against CCL4-induced Hepatic Damage in Albino Rats Open
The aromatic herb Rosmarinus officinalis L. (Rosemary) is from the Lamiaceae family and has been traditionally used in culinary and folk medicine for various ailments, including liver disorders. In this study, we evaluated the hepatoprotec…
View article: Two Uncoating Techniques for Measuring Cold-Formed Steel Residual Stress Using Cos-α X-ray Diffraction Method
Two Uncoating Techniques for Measuring Cold-Formed Steel Residual Stress Using Cos-α X-ray Diffraction Method Open
The cold-bending effect during the roll-forming process may affect the material's mechanical properties and induce residual stress in the cold-formed steel sections. Cos-α X-ray Diffraction is an appropriate method for measuring residual s…
View article: Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic–Antimicrobial Peptide Conjugates
Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic–Antimicrobial Peptide Conjugates Open
In recent years, bacterial resistance to conventional antibiotics has become a major concern in the medical field. The global misuse of antibiotics in clinics, personal use, and agriculture has accelerated this resistance, making infection…
View article: Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic‐Antimicrobial Peptide Conjugates
Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic‐Antimicrobial Peptide Conjugates Open
In recent years, bacterial resistance to conventional antibiotics has become a major concern in the medical field. The global misuse of antibiotics in clinics, personal use, and agriculture has accelerated this resistance, making infection…
View article: Data from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Data from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody–drug conjugates (ADC). For full control over drug–antibody ratio (DAR) and the effect thereof on pharmac…
View article: Supplementary Figure 4 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 4 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Biodistribution of 89Zr-trastuzumab. The 89Zr uptake of 89Zr-trastuzumab in A N87 and B JIMT-tumor bearing mice at 3, 24, 48 and 72 h after injection; data are presented as %ID/g {plus minus} SD.
View article: Data from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Data from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody–drug conjugates (ADC). For full control over drug–antibody ratio (DAR) and the effect thereof on pharmac…
View article: Supplementary Figure 5 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 5 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vivo efficacy of TUB-OMOM-trastuzumab JIMT-tumor bearing mice. The effect after a single i.p. injection of NaCl (control, red line), trastuzumab (15 mg/kg, green line),15 mg/kg TUB-OMOM-trastuzumab (blue line), 30 mg/kg TUB-OMOM-trastuz…
View article: Supplementary Figure 5 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 5 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vivo efficacy of TUB-OMOM-trastuzumab JIMT-tumor bearing mice. The effect after a single i.p. injection of NaCl (control, red line), trastuzumab (15 mg/kg, green line),15 mg/kg TUB-OMOM-trastuzumab (blue line), 30 mg/kg TUB-OMOM-trastuz…
View article: Supplementary Figure 1 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 1 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vitro relative cell viability of JIMT, MDA-MB231, N87, SKBr3 and SKOV cells incubated with A TUB-OH and B TUB-OMOM. Representative experiments are shown, performed with six replicates per concentration. Data are presented as mean {plus …
View article: Supplementary Figure 4 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 4 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Biodistribution of 89Zr-trastuzumab. The 89Zr uptake of 89Zr-trastuzumab in A N87 and B JIMT-tumor bearing mice at 3, 24, 48 and 72 h after injection; data are presented as %ID/g {plus minus} SD.
View article: Supplementary Figure 2 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 2 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Blood kinetics of 131-I-TUB-OH-trastuzumab (2 eq; dashed line) and 124-I-trastuzumab in non-tumor bearing mice. Data are presented as %ID/g {plus minus} SD.
View article: Supplementary Figure 1 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 1 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vitro relative cell viability of JIMT, MDA-MB231, N87, SKBr3 and SKOV cells incubated with A TUB-OH and B TUB-OMOM. Representative experiments are shown, performed with six replicates per concentration. Data are presented as mean {plus …
View article: Supplementary Figure 3 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 3 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vivo biodistribution. The complete biodistribution in JIMT-tumor bearing mice of A 131-I-TUB-OMOM-trastuzumab (2 eq) at 3, 24, 48 and 72 h after injection and B 131-I-TUB-OMOM-trastuzumab (4 eq) at 3, 24, 48 and 72 h after injection. Th…
View article: Supplementary Figure 3 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 3 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
In vivo biodistribution. The complete biodistribution in JIMT-tumor bearing mice of A 131-I-TUB-OMOM-trastuzumab (2 eq) at 3, 24, 48 and 72 h after injection and B 131-I-TUB-OMOM-trastuzumab (4 eq) at 3, 24, 48 and 72 h after injection. Th…
View article: Supplementary Figure 2 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
Supplementary Figure 2 from Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling Open
Blood kinetics of 131-I-TUB-OH-trastuzumab (2 eq; dashed line) and 124-I-trastuzumab in non-tumor bearing mice. Data are presented as %ID/g {plus minus} SD.
View article: Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy
Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy Open
We designed and synthesized perhexiline analogues that have the same therapeutic profile as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 metabolism. Cycloalkyl perhexiline analogues 6a-j were fo…
View article: A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives
A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives Open
View article: The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2
The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2 Open