Monica Uddin
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View article: Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort
Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort Open
DNA methylation (DNAm) has been suggested to play a critical role in post-traumatic stress disorder (PTSD), through mediating the relationship between trauma and PTSD. However, this underlying mechanism of PTSD for African Americans still …
View article: Current Pattern of Correlates of Successful Quitting Methods of Tobacco Smoking in Bangladesh
Current Pattern of Correlates of Successful Quitting Methods of Tobacco Smoking in Bangladesh Open
Tobacco smoking remains a significant public health issue, particularly in low- and middle-income countries like Bangladesh, where cessation rates are low despite extensive tobacco control initiatives. The aims of this study are to examine…
View article: The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort.
The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort. Open
Epigenetics influence and are influenced by the impact of social and environmental challenges on biological outcomes. Therefore, pinpointing epigenetic factors associated with social adversity and traumatic stress enables understanding of …
View article: Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort
Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort Open
Posttraumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, PT…
View article: Differentially expressed heterogeneous overdispersion genes testing for count data
Differentially expressed heterogeneous overdispersion genes testing for count data Open
The mRNA-seq data analysis is a powerful technology for inferring information from biological systems of interest. Specifically, the sequenced RNA fragments are aligned with genomic reference sequences, and we count the number of sequence …
View article: Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts Open
Background The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. T…
View article: Clonal Hematopoiesis Is Associated with Higher Risk of Stroke
Clonal Hematopoiesis Is Associated with Higher Risk of Stroke Open
Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was…
View article: Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts
Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts Open
View article: Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD
Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD Open
DNA methylation (DNAm) has been shown to mediate causal effects from traumatic experiences to post-traumatic stress disorder (PTSD). However, the scientific question about whether the mediation effect changes over time remains unclear. In …
View article: Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference Open
View article: Leveraging DNA Methylation to Predict Treatment Response in Major Depressive Disorder: A Critical Review
Leveraging DNA Methylation to Predict Treatment Response in Major Depressive Disorder: A Critical Review Open
Background Major depressive disorder (MDD) is a debilitating and prevalent mental disorder with a high disease burden. Despite a wide array of different treatment options, many patients do not respond to initial treatment attempts. Selecti…
View article: Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study
Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study Open
View article: Association between gene methylation and experiences of historical trauma in Alaska Native peoples
Association between gene methylation and experiences of historical trauma in Alaska Native peoples Open
Background Historical trauma experienced by Indigenous peoples of North America is correlated with health disparities and is hypothesized to be associated with DNA methylation. Massive group traumas such as genocide, loss of land and foodw…
View article: The association between residential proximity to brownfield sites and high-traffic areas and measures of immunity
The association between residential proximity to brownfield sites and high-traffic areas and measures of immunity Open
View article: A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke
A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke Open
Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian rand…
View article: Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort
Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort Open
Post-traumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, P…
View article: Differentially Expressed Heterogeneous Overdispersion Genes Testing for Count Data*
Differentially Expressed Heterogeneous Overdispersion Genes Testing for Count Data* Open
The mRNA-seq data analysis is a powerful technology for inferring information from biological systems of interest. Specifically, the sequenced RNA fragments are aligned with genomic reference sequences, and we count the number of sequence …
View article: Stressful life events and accelerated biological aging over time in youths
Stressful life events and accelerated biological aging over time in youths Open
View article: Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women Open
Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of gray matter volume (GMV), surface area (SA), and cortical t…
View article: Rare copy number variation in posttraumatic stress disorder
Rare copy number variation in posttraumatic stress disorder Open
View article: Community Engagement in Epigenomic and Neurocognitive Research on Post-Traumatic Stress Disorder in Rwandans Exposed to the 1994 Genocide against the Tutsi: Lessons Learned
Community Engagement in Epigenomic and Neurocognitive Research on Post-Traumatic Stress Disorder in Rwandans Exposed to the 1994 Genocide against the Tutsi: Lessons Learned Open
Epigenomic and neurocognitive studies have provided new perspectives on post-traumatic stress disorder and its intergenerational transmission. This article outlines the lessons learned from community engagement (CE) in such research on Rwa…
View article: Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 studies with 88,316 MD cases and 902,757 controls to …
View article: Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort
Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort Open
DNA methylation (DNAm) has been suggested to play a critical role in post-traumatic stress disorder (PTSD), through mediating the relationship between trauma and PTSD. However, this underlying mechanism of PTSD for African Americans still …
View article: Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD
Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD Open
View article: Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations Open
Background Altered DNA methylation (DNAm) may be one pathway through which early-life adversity (ELA) contributes to adverse mental and physical health outcomes. This study investigated whether the presence versus absence of ELA experience…
View article: Blood-derived DNA methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Blood-derived DNA methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women Open
Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of grey matter volume (GMV), surface area (SA), and cortical t…
View article: DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder Open
View article: Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype
Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype Open
Post-traumatic stress disorder (PTSD) is a psychiatric disorder and patients diagnosed with PTSD often express other comorbid health issues, particularly autoimmune and inflammatory disorders. Our previous reports investigating peripheral …
View article: Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan
Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan Open
Although the effects of lead, mercury, manganese, and copper on individual disease processes are well understood, estimating the health effects of long-term exposure to these metals at the low concentrations often observed in the general p…
View article: Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort
Heterogeneous Mediation Analysis on Epigenomic PTSD and Traumatic Stress in a Predominantly African American Cohort Open
DNA methylation (DNAm) has been suggested to play a critical role in post-traumatic stress disorder (PTSD), through mediating the relationship between trauma and PTSD. However, this underlying mechanism of PTSD for African Americans still …