Moniek Bresser
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View article: ToolCAP: Novel Tools to improve management of paediatric Community-Acquired Pneumonia - a randomized controlled trial, Statistical Analysis Plan
ToolCAP: Novel Tools to improve management of paediatric Community-Acquired Pneumonia - a randomized controlled trial, Statistical Analysis Plan Open
The ToolCAP cohort study is a prospective, observational, multi-site platform study designed to collect harmonized, high-quality clinical, imaging, and biological data on children with IMCI-defined pneumonia in low- and middle-income count…
View article: Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and Lesotho
Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and Lesotho Open
Importance Hypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple comb…
View article: Evaluation of C-Reactive Protein and Computer-Aided Analysis of Chest X-rays as Tuberculosis Triage Tests at Health Facilities in Lesotho and South Africa
Evaluation of C-Reactive Protein and Computer-Aided Analysis of Chest X-rays as Tuberculosis Triage Tests at Health Facilities in Lesotho and South Africa Open
Background To improve tuberculosis case-finding, rapid, non-sputum triage tests need to be developed according to the World Health Organization target product profile (TPP) (>90% sensitivity, >70% specificity). We prospectively evalu…
View article: ToolCAP: Novel Tools to Improve the Management of Paediatric Community-Acquired Pneumonia – a Preliminary Study Protocol for a Randomised Controlled Trial
ToolCAP: Novel Tools to Improve the Management of Paediatric Community-Acquired Pneumonia – a Preliminary Study Protocol for a Randomised Controlled Trial Open
Background Lower respiratory tract infections (LRTIs), particularly pneumonia, are a leading cause of morbidity and mortality among children worldwide, especially in low-resource settings. The World Health Organization (WHO) Integrated Man…
View article: Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial
Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial Open
For the Sesotho and Swahili translations of the abstract see Supplementary Materials section.
View article: Low tuberculosis treatment initiation after positive tuberculosis lipoarabinomannan results
Low tuberculosis treatment initiation after positive tuberculosis lipoarabinomannan results Open
A positive urine TB-LAM result should lead to TB treatment initiation. TB treatment uptake was low after a positive TB-LAM but negative Xpert test. A lack of trust in TB-LAM results by clinicians and false-positive results may contribut…
View article: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia Open
Introduction The use of antigen rapid tests (Ag-RDTs) for self-testing is an important element of the COVID-19 control strategy and has been widely supported. However, scale-up of self-testing for COVID-19 in sub-Saharan Africa is still in…
View article: Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: A mixed-methods evaluation
Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: A mixed-methods evaluation Open
During TB-case finding, we assessed the feasibility of implementing the advanced HIV disease (AHD) care package, including VISITECT CD4 Advanced Disease (VISITECT), a semiquantitative test to identify a CD4≤200cells/μl. Adult participants …
View article: COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests
COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests Open
Artificial intelligence (AI) systems for detection of COVID-19 using chest X-Ray (CXR) imaging and point-of-care blood tests were applied to data from four low resource African settings. The performance of these systems to detect COVID-19 …
View article: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Lesotho data
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Lesotho data Open
Dataset with Lesotho data belonging to the publication: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia
View article: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data Open
Dataset with Zambia data belonging to the publication: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data
View article: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data Open
Dataset with Zambia data belonging to the publication: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Zambia data
View article: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Lesotho data
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia - Lesotho data Open
Dataset with Lesotho data belonging to the publication: Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia
View article: Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho Open
The surge of the COVID-19 pandemic challenged health services globally, and in Lesotho, the HIV and tuberculosis (TB) services were similarly affected. Integrated, multi-disease diagnostic services were proposed solutions to mitigate these…
View article: Creating access to SARS-CoV-2 screening and testing through community-based COVID-19 case-finding, observations from cross-sectional studies in Lesotho and Zambia
Creating access to SARS-CoV-2 screening and testing through community-based COVID-19 case-finding, observations from cross-sectional studies in Lesotho and Zambia Open
View article: Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic Open
These are pseudo-randomized data from the MISTRAL study: "Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic". The data dictionary explains the data.…
View article: Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic Open
These are pseudo-randomized data from the MISTRAL study: "Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic". The data dictionary explains the data.…
View article: Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho Open
Objectives To assess the real-world diagnostic performance of nasal and nasopharyngeal swabs for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT). Methods Individuals ≥5 years with COVID-19 compatible symptoms or his…
View article: Evaluation of Covid-19 Ag-RDTs self-testing in Lesotho and Zambia
Evaluation of Covid-19 Ag-RDTs self-testing in Lesotho and Zambia Open
Background The use of antigen rapid tests (Ag-RDTs) for self-testing is an important element of the COVID-19 control strategy and has been widely supported. However, scale-up of self-testing for COVID-19 in sub-Saharan Africa is still insu…
View article: Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho Open
Introduction The surge of the COVID-19 pandemic challenged health services globally, and in Lesotho, the HIV and tuberculosis (TB) services were similarly affected. Integrated, multi-disease diagnostic services were proposed solutions to m…
View article: Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho Open
These are pseudo-anonymised data from the MISTRAL study: "Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho". The data dictionary explains the data available in the dataset. Betw…
View article: Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho Open
These are pseudo-anonymised data from the MISTRAL study: "Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho". The data dictionary explains the data available in the dataset. Betw…
View article: Diagnosis of SARS-CoV-2 infection from breath - a proof-of-concept study
Diagnosis of SARS-CoV-2 infection from breath - a proof-of-concept study Open
Bioaerosol capture and analysis is emerging as a non-invasive diagnostic method for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this proof-of-concept study conducted in Lesotho, we evaluated the novel …
View article: Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho Open
Objectives To assess the real-world diagnostic performance of nasal and nasopharyngeal swabs for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT). Methods Individuals ≥5 years with COVID-19 compatible symptoms or his…
View article: Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomized clinical trial
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomized clinical trial Open
Background Community-based antiretroviral therapy (ART) dispensing by lay workers is an important differentiated service delivery model in sub-Sahara Africa. However, patients new in care are generally excluded from such models. Home-based…
View article: Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial Open
These are pseudo-anonymised data from the VIBRA randomized trial: "Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised c…
View article: Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial Open
These are pseudo-anonymised data from the VIBRA randomized trial: "Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised c…
View article: The coArtHA trial—identifying the most effective treatment strategies to control arterial hypertension in sub-Saharan Africa: study protocol for a randomized controlled trial
The coArtHA trial—identifying the most effective treatment strategies to control arterial hypertension in sub-Saharan Africa: study protocol for a randomized controlled trial Open
View article: Offering ART Refill Through Community Health Workers Versus Clinic-Based Follow-Up After Home-Based Same-Day ART Initiation: The VIBRA Cluster-Randomised Clinical Trial
Offering ART Refill Through Community Health Workers Versus Clinic-Based Follow-Up After Home-Based Same-Day ART Initiation: The VIBRA Cluster-Randomised Clinical Trial Open
View article: The coArtHA Trial - Identifying the Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa: Study Protocol for a Randomized Controlled Trial
The coArtHA Trial - Identifying the Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa: Study Protocol for a Randomized Controlled Trial Open
Background Arterial hypertension is the most prevalent risk factor for cardiovascular disease in sub-Saharan Africa. Only a few and mostly small randomized trials have studied antihypertensive treatments in people of African descent living…