Explanipedia

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in <i>NPM1</i>-mutant AML Open

Aristi Damaskou, Rachael Wilson, Malgorzata Gozdecka, George Giotopoulos, Ryan Asby , et al. · 2025

NPM1 is a multifunctional phosphoprotein with key roles in ribosome biogenesis among its many functions. NPM1 gene mutations drive 30% of acute myeloid leukemia (AML) cases. The mutations disrupt a nucleolar localization signal and create …

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis Open

Malgorzata Gozdecka, Monika Dudek, Sean Wen, Muxin Gu, Richard J Stopforth , et al. · 2025

Somatic DNMT3A -R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk 1,2 . Preventing expansion of DNMT3A -R882-mutant haematopoietic stem/progen…

Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs Open

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek , et al. · 2022

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England Open

Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen , et al. · 2022

Genomic reconstruction of the SARS-CoV-2 epidemic in England Open

Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen , et al. · 2021

The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 G…

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML Open

Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan , et al. · 2019

Epigenetic regulators, such as EZH2, are frequently mutated in cancer, and loss-of-function EZH2 mutations are common in myeloid malignancies. We have examined the importance of cellular context for Ezh2 loss during the evolution of acute …

Effects of ovariectomy and sex hormone replacement on the number of neurokinin B-immunoreactive neurons in the arcuate nucleus of the hypothalamus of obese and diabetic female rats Open

Kamil Ziarniak, Paweł Kołodziejski, Ewa Pruszyńska‐Oszmałek, M. Sassak, Monika Dudek , et al. · 2019

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 Open

Konstantinos Tzelepis, Étienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar , et al. · 2018

Dangerous liaisons for pubertal maturation: the impact of alcohol consumption and obesity on the timing of puberty† Open

Joanna H. Śliwowska, Kamil Ziarniak, Monika Dudek, Julia Matuszewska, Manuel Tena‐Sempere · 2018

Acquisition of reproductive maturity involves one of the most important series of developmental events in an organism's life. The beginning of adolescence is marked by the onset of puberty. Puberty is the continuum of physical changes thro…

In vitro virulence characteristics of rare serovars of Salmonella enterica isolated from sand lizards (Lacerta agilis L.) Open

Joanna Mokracka, Sylwia Krzymińska, Д. А. Алтунин, Dariusz Wasyl, Ryszard Koczura , et al. · 2018

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs Open

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek , et al. · 2018

Kisspeptin and Metabolism: The Brain and Beyond Open

Monika Dudek, Kamil Ziarniak, Joanna H. Śliwowska · 2018

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons local…

The occurrence of pathogens in Rhipicephalus microplus ticks from cattle in Madagascar Open

A. Matysiak, Paulina Dudko, Krzysztof Dudek, Monika Dudek, Andrzej Junkuszew , et al. · 2016

Rhipicephalus microplus is one of the most important ectoparasites of cattle in tropical and subtropical regions. In ticks collected from cattle the pathogens Babesia bovis, Anaplasma spp. and Ehrlichia spp. can be detected. Here, we repor…

Invasive Canadian goldenrod (Solidago canadensis L.) as a preferred foraging habitat for spiders Open

Krzysztof Dudek, Michał Michlewicz, Monika Dudek, Piotr Tryjanowski · 2016

Invasions of alien species are a great threat to biodiversity and native species communities. There are many examples in the literature on how the invasive plants affect the natural environment. Beside reports on negative effects of these …

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